A5103190947- Drug-Induced Adverse Reactions
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Monoclonal and Polyclonal Antibodies Research
- Mast cells and histamine
- T-cell and B-cell Immunology
- Contact Dermatitis and Allergies
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Pharmacological Effects of Natural Compounds
- Enzyme Structure and Function
- Medical and Biological Ozone Research
- Hydrogen's biological and therapeutic effects
- Anesthesia and Neurotoxicity Research
- Asthma and respiratory diseases
- Dermatologic Treatments and Research
- Therapeutic Uses of Natural Elements
- Eosinophilic Disorders and Syndromes
- Pharmacovigilance and Adverse Drug Reactions
- Glycosylation and Glycoproteins Research
- Systemic Lupus Erythematosus Research
- Acne and Rosacea Treatments and Effects
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Traditional Chinese Medicine Analysis
Shanghai Clinical Research Center
2024
Huashan Hospital
2015-2024
Fudan University
2015-2024
Jiangxi Pingxiang People's Hospital
2021
Zhengzhou University
2016
Children's Hospital of Fudan University
2016
Institute of Biomedical Science
2016
University Hospitals of Cleveland
2005
Case Western Reserve University
2005
Aim: Salazosulfapyridine (SASP) frequently causes several adverse reactions, such as drug rash with eosinophilia and systemic symptoms (DRESS). This study aims to assess whether there is an association between SASP-induced DRESS HLA-A, -B -C alleles in the Chinese Han population. Subjects & methods: We performed of six subjects DRESS, 30 SASP-tolerant patients 283 general from human MHC database, all whom are Chinese. Results: The frequency carrying HLA-B*13:01 allele 66.67% (4/6). It...
Keratinocyte death is a hallmark of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). Apoptotic signal-associated cytokines, such as TNF-α, sFasL, granulysin, sTRAIL IFN-γ have been reported to participate in keratinocyte apoptosis. However, their levels are variable, which hampers the elucidation role these cytokines. We sought determine whether cytokine vary with disease course.The serum 24 patients blister fluid 10 were analysed by enzyme-linked immunosorbent assay on...
Methazolamide (MTZ) has been occasionally linked to the lethal Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which are associated with HLA-B*59:01. However, some MTZ-induced SJS/TEN (MTZ-SJS/TEN) cases negative for HLA-B*59:01, implying that other genetic factors besides HLA-B*59:01 contributing MTZ-SJS/TEN.To comprehensively identify HLA non-HLA susceptibility MTZ-SJS/TEN in Han Chinese.Eighteen patients MTZ-SJS/TEN, 806 subjects of population control 74 MTZ-tolerant...
Background and Objectives To evaluate the efficacy safety of fractional 1064 nm Nd:YAG picosecond laser combined with intense pulsed light (IPL) in treatment atrophic acne scar post‐inflammatory erythema (PIE). © 2021 Wiley Periodicals LLC. Study Design/Materials Methods Seventeen patients received five sessions at weeks 0, 4, 8, 12, 16 were followed up week 28. One half face was randomly treated by IPL (FxPico + IPL), other alone as a control. Results For 15 who completed study, FxPico side...
Background Amoxicillin (AMX) is among the most prescribed and best tolerated antimicrobials worldwide. However, it can occasionally trigger severe cutaneous adverse reactions (SCAR) with a significant morbidity mortality. The genetic factors that may be relevant to AMX-induced SCAR (AMX-SCAR) remain unclear. Identification of risk factor prevent patients from AMX exposure resume therapy other falsely implicated drugs. Methodology Four AMX-SCAR, 1,000 population control 100 AMX-tolerant...
The HLA-B*58:01 allele is associated with allopurinol-induced severe cutaneous adverse drug reactions (sCADR) in certain geographic regions, but the diversity of correlation large. In addition, currently available testing methods are too laborious for use routine clinical detection. objective this study was to develop a new, convenient method detection and investigate association sCADR Han Chinese population.A new combining sequence-specific primers (SSP) TaqMan probe amplification developed...
Abstract: We have previously demonstrated that iC3b is deposited at the dermal – epidermal junction of skin following ultraviolet (UV) exposure and it plays a role in UV‐induced immunosuppression antigenic tolerance. In vitro , differentially regulates monocyte production interleukin‐10 (IL‐10) IL‐12. Additionally, arrests monocytic cell differentiation into CD1c‐expressing dendritic (DC) precursors. The present study addresses mitogen‐activated protein kinase (MAPK) signalling cross‐linking...
Cutaneous adverse drug reactions (CADRs) are drug-induced skin with or without systemic involvement, ranging from mild maculopapular exanthema (MPE) to life-threatening severe CADRs (S-CADRs). Due their unpredictability and severity, early recognition of suspected causative drugs is highly recommended. However, the profile remains unknown in China. To assess clinical profile, predominant drugs, cost associated Shanghai, Clinical records inpatients admitted a diagnosis dermatology ward...
The β-1,4 galactosylation catalyzed by galactosyltransferases (β4Gal-Ts) is not only closely associated with diverse physiological and pathological processes in humans but also widely applied the N-glycan modification of protein glycoengineering. loop-closing process β4Gal-Ts an essential intermediate step intervening binding events donor substrate (UDP-Gal/Mn2+) acceptor during its catalytic cycle, a significant impact on activities. However, molecular mechanisms regulating dynamics are...
Tetanus antitoxin (TAT) is an effective antitetanus medicine, but may sometimes cause adverse drug reactions such as rapid-onset anaphylactic shock and late-onset cutaneous reactions, including exanthematous eruptions (EDE). Human leukocyte antigen (HLA) class I alleles are strongly associated with different types of reactions. This study aimed to assess whether there association between TAT-induced EDE HLA-A, HLA-B, HLA-C in the Chinese Han population.We carried out 15 patients two groups...
Metronidazole, a widely used drug for the treatment of infections with anaerobic and facultative bacteria protozoa, can frequently cause metronidazole-induced cutaneous adverse reactions (McADRs). The aim present study was to investigate association between human leucocyte antigen (HLA) alleles McADRs in Chinese Han population. frequency HLA-B*24:02 carriers among McADR patients 73.3%, which significantly higher than that population controls (32.16%, OR = 5.80, 95% CI [1.80-18.72], Pc 0.004)...
Levofloxacin-induced severe cutaneous adverse drug reactions (LEV-SCARs) remain unexplored. An association study of human leukocyte antigen (HLA) alleles with LEV-SCARs among 12 patients, 806 healthy subjects, and 100 levofloxacin-tolerant individuals was performed. The carrier frequencies HLA-B∗13:01 (odds ratio [OR]: 4.50; 95% confidence interval [CI]: 1.15-17.65; p = 0.043), HLA-B∗13:02 (OR: 6.14; CI: 1.73-21.76; 0.0072), serotype B13 17.73; 3.61-86.95; 4.85 × 10-5) in patients were...
The majority of patients who experience cutaneous adverse drug reactions (cADRs) concurrently receive multiple medications, meaning that the causative remains unidentified. We explored association between human leukocyte antigen (HLA) alleles and cADRs, regardless allergenic drug, to investigate whether different drug-induced cADRs were associated with same or similar risk in a Han Chinese population. genotyped sample 146 cADR 230 population controls from hospital systematically analyzed HLA...