A5058632240- Parkinson's Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Ferroptosis and cancer prognosis
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- Chromatography in Natural Products
- Cardiovascular Syncope and Autonomic Disorders
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Food Quality and Safety Studies
- Lysosomal Storage Disorders Research
- Sports injuries and prevention
- Trace Elements in Health
- Microbial Natural Products and Biosynthesis
- Neuroscience and Neuropharmacology Research
- Neurological Disorders and Treatments
- MicroRNA in disease regulation
- Agriculture, Soil, Plant Science
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Botulinum Toxin and Related Neurological Disorders
- Flowering Plant Growth and Cultivation
Southern Medical University
2018-2025
Central South University
2024-2025
Second Xiangya Hospital of Central South University
2024-2025
Zhujiang Hospital
2018-2025
Macau University of Science and Technology
2024
Guangzhou University of Chinese Medicine
2020-2023
Innovation Research Center
2023
North China Electric Power University
2023
Shenzhen Pingle Orthopedic Hospital
2021-2022
Wuhan University of Science and Technology
2020
Neuroinflammation and mitochondrial impairment play important roles in the neuropathogenesis of Parkinson's disease (PD). The activation NLRP3 inflammasome accumulation α-synuclein (α-Syn) are strictly correlated to neuroinflammation. Therefore, regulation α-Syn aggregation might have therapeutic potential. It has been indicated that Dl-3-n-butylphthalide (NBP) produces neuroprotection against some neurological diseases such as ischemic stroke. We here intended explore whether NBP suppressed...
Lipoprotein-associated phospholipase A2 (Lp-PLA2) and superoxide dismutase (SOD) are linked to regulating vascular/neuro-inflammation stroke. Using a retrospective design, we investigated whether circulating Lp-PLA2 SOD in cerebral small vessel disease (CSVD) patients were associated with cognitive impairment. Eighty-seven CSVD recruited. Plasma determined, status was measured by the Mini-Mental State Examination (MMSE) Montreal Cognitive Assessment (MoCA). The severity of white matter...
Parkinson's disease (PD) is a neurodegenerative characterized by the selective loss of dopaminergic neurons in substantia nigra (SN). In previous study, authors demonstrated that ferritin heavy chain 1 (FTH1) inhibited ferroptosis model 6‑hydroxydopamine (6‑OHDA)‑induced PD. However, whether and how microRNAs (miRNAs/miRs) modulate FTH1 PD not yet well understood. present <em>in vivo</em> vitro</em> models induced 6‑OHDA were established. The results revealed levels marker protein,...
Aim: Oxidative stress and inflammation play critical roles in the neuropathogenesis of PD. We aimed to evaluate oxidative status by measuring serum superoxide dismutase (SOD) with lipoprotein cholesterol high-sensitivity C-reactive protein (hsCRP) respectively PD patients, explore their correlation disease severity. Methods: performed a cross-sectional study that included 204 patients age-matched healthy controls (HCs). Plasma levels SOD, hsCRP, total cholesterol, high-density (HDL-C)...
In a prospective longitudinal study with 218 Parkinson's disease (PD) patients in the discovery cohort and 84 validation cohort, we aimed to identify novel blood biomarkers predicting disability milestones PD. Through Least Absolute Shrinkage Selection Operator-Cox (Lasso-Cox) regression, developed nomogram predictive model Linear mixed-effects models, identified low level of plasma fibronectin (pFN) as one best-performing risk markers milestones. A pFN was associated short milestone-free...
Abstract Background Both psychogenic pseudosyncope (PPS) and vasovagal syncope (VVS) in children adolescents are diseases of transient loss consciousness. It is difficult to distinguish them clinically. This paper will study the differential diagnostic value P wave dispersion (Pd) QT interval (QTd) between PPS VVS. Methods The 31 with 40 VVS from July 2014 November 2023 were enrolled as group. Meanwhile, 30 healthy who underwent a physical examination at same hospital matched control...
Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease arising from accumulation of the α-synuclein and aberrant protein clearance in oligodendrocytes. The mechanisms autophagy involved progression MSA remain poorly understood. It reported that patients have blood-brain barrier impairments, which may increase entry fibrinogen into brain. However, roles its degradation products (FDPs) on unknown. Here, we established animal model by intraperitoneal injection...
Abstract To evaluate the correlation between “hot cross bun” sign (HCBs) and disease severity in multiple system atrophy (MSA). We recruited patients with probable possible MSA parkinsonism (MSA-P) or cerebellar ataxia (MSA-C) subtypes. Clinical imaging characteristics were collected comparison was performed MSA-C MSA-P cases. Spearman test used to HCBs other variables. Curve estimate general linear regression relationship Scale for Assessment Rating of Ataxia (SARA). Unified Multiple System...
Parkinson’s disease (PD) is a common neurodegenerative in the elderly, which related to brain iron metabolism disorders. Ferroptosis newly discovered iron-dependent programmed cell death mode, has been considered an essential mechanism of PD pathogenesis recent years. However, its underlying mechanisms have not fully understood. In present study, rat model and were induced by 6-hydroyxdopamine (6-OHDA). The results showed that expression Sorting Nexin 5 (SNX5) level ferroptosis will increase...
Objective: To characterize the clinical phenotypes associated with “hot cross bun” sign (HCBs) on MRI and identify correlations between neuroimaging characteristics. Methods: Firstly, we screened a cohort of patients HCBs from our radiologic information system (RIS) in center. Secondly, systematically reviewed published cases classified all these according to their etiologies. Finally, characterized detail disease spectra heterogeneity. Results : Out total 3,546 who were screened, identified...
BackgroundNACHT and WD repeat domain-containing protein 1 (Nwd1) is a member of the innate immune subfamily. Nwd1 contributes to androgen receptor signaling pathway involved in axonal growth. However, mechanisms that underlie pathophysiological dysfunction seizures remain unclear.MethodsBiochemical methods were used assess expression localization mouse model kainic acid (KA)-induced acute temporal lobe epilepsy (TLE) patients. Electrophysiological recordings measure role regulating synaptic...
Abstract Objective We aimed to identify key susceptibility gene targets in multiple datasets generated from postmortem brains and blood of Parkinson’s disease (PD) patients healthy controls (HC). Methods performed a multitiered analysis integrate the expression data using multiple-gene chips 244 human tissues. identified hub node genes highly PD-related consensus module by constructing protein–protein interaction (PPI) networks. Next, we validated top four interacting 238 subjects (90...
Parkinson's disease dementia (PDD) is a common complication of that seriously affects patients' health and quality life. At present, the process pathological mechanisms PDD remain controversial, which hinders development treatments. An increasing number clinical studies have shown alpha-synuclein (α-syn), tau, beta-amyloid (Aβ), iron are closely associated with severity. Thus, we inferred vicious cycle causes oxidative stress (OS), due to synergistic effects α-syn, Aβ, and, iron, plays...
The Mediterranean diet (MED), a dietary pattern rich in fruits and vegetables, whole grains, legumes, nuts, fish, olive oil, has anti-oxidative anti-inflammatory effects. Although some data suggest that MED adherence is associated with decreased manifestation of depressive symptoms, it remains necessary to further analyze this apparent non-linear association as well the influence different factors on relationship between depression. Here, we investigated associations alternate (aMED) score...
As a sensitive cold-shock protein, RNA binding protein motif 3 (RBM3) exhibits neuroprotective function in the condition of brain injury. However, how RBM3 is involved acute ischemic stroke by affecting stress granules (SGs) remains unclear. Here, we established an oxygen-glucose deprivation/reperfusion (OGD/R) model rat primary cortical neurons and PC12 cells to explore potential mechanism between SG formation ischemic/reperfusion (I/R) condition. The immunofluorescence results showed that...
Abstract Retinal thickness is related to Parkinson’s disease (PD), but its association with the severity of PD still unclear. We conducted a Mendelian randomized (MR) study explore between retinal and PD. For two-sample MR analysis, summary statistics obtained from genome-wide studies on nerve fiber layer (RNFL) ganglion cell inner plexiform (GCIPL) were employed as exposure, while associated used outcome. The primary approach utilized was inverse variance weighted. To correct for multiple...
Ferroptosis is associated with neural degeneration of dopaminergic neurons in Parkinson’s disease (PD). However, how to control the level ferroptosis PD remains unclear. Clinically, moxibustion has been used treat and an apparent therapeutic effect on improving motor symptoms PD. In present study, rat model was constructed by two-point stereotactic 6-hydroxydopamine injection. Then, rats. The expression glutathione peroxidase 4 (GPX4) Ferritin Heavy Chain 1 (FTH1), reactive oxygen species...
Chronic cerebral hypoperfusion (CCH) is a cardinal risk factor for Parkinson’s disease dementia (PDD), but this potential causality lacks mechanistic evidence. We selected bilateral common carotid artery occlusion (BCCAO) to simulate chronic in the rat model of PD induced by typical neurotoxin 6-hydroxy dopamine (6-OHDA). Four weeks after unilateral injection 6-OHDA into medial forebrain bundle, rats underwent BCCAO. Male Sprague-Dawley were divided five groups ten, including sham, PD+BCCAO...
Parkinson's disease (PD) and atypical parkinsonism (AP), including progressive supranuclear palsy (PSP) multiple system atrophy (MSA), share similar nonmotor symptoms. Quantitative electroencephalography (QEEG) can be used to examine the This study aimed characterize patterns of QEEG functional connectivity (FC) that differentiate PD from PSP or MSA, explore correlation between differential indices dysfunctions in AP. We enrolled 52 patients with PD, 31 22 PSP, 50 age-matched health controls...
Tephrosin is a natural rotenoid isoflavonoid that has been shown to have potent anticancer activities. In this study, we reported the activity of tephrosin against pancreatic cancer cells. potently suppressed cell viability in various lines and promoted apoptosis PANC-1 SW1990 cells evidenced by enhanced cleavage caspase-3/-9 PARP. Further studies showed increased production intracellular reactive oxygen species (ROS) led mitochondrial membrane potential depolarization, subsequent cytochrome...
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