A5063579534- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Parkinson's Disease Mechanisms and Treatments
- Hemodynamic Monitoring and Therapy
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Neuroendocrine Tumor Research Advances
- Respiratory Support and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Lung Cancer Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Screening and Detection
- Anesthesia and Neurotoxicity Research
- Inflammatory Bowel Disease
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Escherichia coli research studies
- Scoliosis diagnosis and treatment
- IL-33, ST2, and ILC Pathways
- Social and Behavioral Studies
- Inflammatory Biomarkers in Disease Prognosis
- Biotin and Related Studies
Shandong University of Traditional Chinese Medicine
2025
Ningbo First Hospital
2025
Ningbo University
2025
Zhujiang Hospital
2011-2024
Southern Medical University
2011-2024
Zhejiang University
2021-2024
Ministry of Education of the People's Republic of China
2024
Second Affiliated Hospital of Zhejiang University
2017-2024
Dalian Maternal and Child Health Hospital
2022
Christie's
2017
Mounting evidences have indicated that long noncoding RNAs (lncRNAs) play pivotal roles in human diseases, especially cancers. Recently, TINCR was proposed to be involved tumor progression. However, its role colorectal cancer (CRC) remains elusive. In our study, we found SP1-induced significantly upregulated CRC tissues and cell lines. Moreover, cox multivariate survival analysis revealed high an independent predictor of poor overall (OS). Functionally, knockdown obviously suppressed cells...
Vitamin D is an open-cyclic steroidal trace organic compound that plays a crucial role in human metabolism and nutritional health. In recent years, Mendelian randomization (MR) has emerged as widely adopted method for analyzing causal relationships, particularly studying the association between related diseases. However, no bibliometric analyses have been conducted to explore research hotspots trends regarding status MR studies. This study utilized Web of Science Core Collection source...
Abstract Objective We aimed to identify key susceptibility gene targets in multiple datasets generated from postmortem brains and blood of Parkinson’s disease (PD) patients healthy controls (HC). Methods performed a multitiered analysis integrate the expression data using multiple-gene chips 244 human tissues. identified hub node genes highly PD-related consensus module by constructing protein–protein interaction (PPI) networks. Next, we validated top four interacting 238 subjects (90...
Purpose To determine whether LARC with negative mesorectal fascia (MRF) predicted by magnetic resonance imaging (MRI) can be excluded from preoperative radiotherapy treatment. Method This multicenter, open-label, non-inferiority, randomized clinical trial enrolled patients within 6–12 cm the anal verge and MRI-predicted MRF. Participants were to intervention group (primary surgery, in which positive pathological circumferential margins (CRM) subjected CRT while CRM undergone adjuvant...
Although the significance of curative effect has been recognized, ideal nanocarriers with properties lysosomal escape and biocompatibility are still lacking for development siRNA-based cancer gene therapy. In this work, a escaped redox-responsive polyacrylamide nanohydrogel (cRGD-9R-PAss) was constructed STAT3 siRNA delivery. The functional groups, including tumor-targeting peptide cRGD, cell-penetrating lysosome-escaping 9R, disulfide bond, were introduced to attain enhanced transfection...
Colorectal cancer (CRC) is the most frequently diagnosed malignancy of gastrointestinal tract. The dysregulation microRNAs (miRNAs/miRs) has been reported in majority types human cancer, and correlated with tumorigenesis tumor development. Abnormal expression miR‑663 observed various cancer. However, little known about its role CRC. Therefore, aim present study was to clarify potential miR‑663, underlying molecular mechanism It that markedly downregulated CRC tissues cell lines. Decreased...
Intestinal fibrosis is one of the most severe complications inflammatory bowel disease (IBD) and frequently requires surgery due to intestinal obstruction. Integrin αvβ6, which mainly regulated by integrin β6 subunit gene (ITGB6), a special subtype expressed only in epithelial cells. In our previous study, we found αvβ6 can promote development IBD, but role remains unclear. this observed gradual increase ITGB6 mRNA expression from normal region stenotic IBD patients' specimens. Next,...
N5-methylcytosine (m5C) methylation modification plays a crucial role in the epigenetic mechanisms underlying tumorigenesis, aggressiveness, and malignancy diffuse glioma. Our study aimed to develop novel prognostic risk-scoring system assess impact of m5C glioma patients. Initially, we identified two distinct clusters based on expression level regulators The Cancer Genome Atlas glioblastoma (TCGA-GBM) dataset. Differentially expressed genes (DEGs) between cluster groups were determined....
Intestinal interstitial fibrosis is a core event of inflammatory bowel disease (IBD) development. Calycosin has been recognized to carry various therapeutic bioactivities. However, the role calycosin in intestinal remains be illustrated. This aim this study was explore effects on IBD and underlying mechanisms. The vitro vivo models were established by using TNBS-induced mouse model co-culture epithelial cells cells; moreover, lentivirus-mediated knockdown NLRP3 expression applied. results...
Colorectal cancer is a leading cause of cancer-related deaths worldwide, with approximately 1.9 million new cases and over 935,000 in 2020. Right-sided colon cancer, subset colorectal represents significant health burden. Laparoscopic surgery has significantly improved postoperative recovery. The superiority one approach or landmark another still argued about due to the lack large-scale prospective studies. However, deep understanding both anatomical variation characteristics each extreme...
Integrins, as a large family of cell adhesion molecules, play crucial role in maintaining intestinal homeostasis. In inflammatory bowel disease (IBD), homeostasis is disrupted. Integrin αvβ6, which mainly regulated by the integrin β6 subunit gene (ITGB6), molecule that mediates cell-cell and cell-matrix interactions. However, ITGB6 pathogenesis IBD remains elusive. this study, we found was markedly upregulated inflamed tissues from patients with IBD. Then, generated an epithelial...
The aim of the present study was to investigate treatment refractory Cryptococcus neoformans encephalitis with continuous administration liposomal amphotericin B (AmB). Liposomal AmB administered a 28-year-old male by intravenous injection, daily increasing dosages up 150 mg per day and combined use fluconazole (0.4 g day) oral flucytosine tablets (1.5 day). Following 5 months treatment, C. could still be detected in ink stain cerebrospinal fluid, but patient not tolerate further increase...
Objectives: Human Urinary Kallidinogenase (HUK) is a tissue kallikrein that plays neuroprotective role in ischemic conditions via different mechanisms. Mild hypothermia (MH) another robust neuroprotectant reduces mortality but does not profoundly ameliorate the neurological outcome hypoxic-ischemic encephalopathy (HIE) patients. However, whether combination of HUK and MH can be used as promising treatment HIE unknown. Methods: One-hundred forty-four adult Wistar rats were randomly divided...