A5045619685- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Lysosomal Storage Disorders Research
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Child Nutrition and Feeding Issues
- Nutritional Studies and Diet
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- Neurological diseases and metabolism
- Mesenchymal stem cell research
- Autism Spectrum Disorder Research
- Adenosine and Purinergic Signaling
- Coenzyme Q10 studies and effects
- Neurological Disease Mechanisms and Treatments
- Nerve injury and regeneration
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Diet and metabolism studies
- Genomic variations and chromosomal abnormalities
- Advanced battery technologies research
National Neuroscience Institute
2014-2025
Singapore General Hospital
2015-2025
Duke-NUS Medical School
2016-2025
National University of Singapore
2007-2024
Tan Tock Seng Hospital
2022
Singapore Immunology Network
2010-2014
Agency for Science, Technology and Research
2010-2014
Background Cell membrane interactions rely on lipid bilayer constituents and molecules inserted within the membrane, including specific receptors. HAMLET (human α-lactalbumin made lethal to tumor cells) is a tumoricidal complex of partially unfolded (HLA) oleic acid that internalized by cells, suggesting with phospholipid and/or receptors may be essential for effect. This study examined whether interacts artificial membranes alters structure. Methodology/Principal Findings We show surface...
There are limited data on vascular, inflammatory, metabolic risk factors of dementia in Parkinson's disease (PD) with type 2 diabetes mellitus (DM) (PD-DM). In a study 928 subjects comprising 215 PD DM (including 31 PD-DM dementia, PD-DMD), 341 without PDD) and 372 35 DMD) patients, we investigated if metabolic, magnetic resonance imaging (MRI) markers were associated PD-DM. Lower fasting blood glucose (FBG<5mmol/L, OR=4.380; 95%CI: 1.748-10.975; p=0.002), higher homocysteine (HCY>15μmol/L,...
Abstract To evaluate the correlation between “hot cross bun” sign (HCBs) and disease severity in multiple system atrophy (MSA). We recruited patients with probable possible MSA parkinsonism (MSA-P) or cerebellar ataxia (MSA-C) subtypes. Clinical imaging characteristics were collected comparison was performed MSA-C MSA-P cases. Spearman test used to HCBs other variables. Curve estimate general linear regression relationship Scale for Assessment Rating of Ataxia (SARA). Unified Multiple System...
Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical channel functions may be perturbed but conserved tumor specific remain to defined. Here we used the tumoricidal protein-lipid complex HAMLET as a probe identify involved in cell death. We show that activates non-selective cation current, which reached magnitude 2.74±0.88 nA within 1.43±0.13 min from application. Rapid were essential for HAMLET-induced carcinoma death inhibitors...
Abstract Objective We aimed to identify key susceptibility gene targets in multiple datasets generated from postmortem brains and blood of Parkinson’s disease (PD) patients healthy controls (HC). Methods performed a multitiered analysis integrate the expression data using multiple-gene chips 244 human tissues. identified hub node genes highly PD-related consensus module by constructing protein–protein interaction (PPI) networks. Next, we validated top four interacting 238 subjects (90...
Parkinson's disease (PD) is one of the most common neurodegenerative diseases in which neuroinflammation plays pivotal roles. An important mechanism NLRP3 inflammasome activation that has been implicated PD pathogenesis. In this perspective, we will discuss relationship some key PD-associated proteins including α-synuclein and Parkin their contribution to activation. We also review promising inhibitors pathway have potential as novel therapeutics. Finally, provide a summary current vitro...
Abstract Blood-based gene expression signatures could potentially be used as biomarkers for PD. However, it is unclear whether genetically-regulated transcriptomic can provide novel candidates use PD biomarkers. We leveraged on the Genotype-Tissue Expression (GTEx) database to impute whole-blood using summary statistics of three large-scale GWAS. A random forest classifier was with consensus imputed signature (IGS) discriminate between cases and controls. Outcome measures included Area under...
Parkinson's disease (PD) is an incurable, progressive and common movement disorder that increasing in incidence globally because of population aging. We hypothesized the landscape rare, protein-altering variants could provide further insights into pathogenesis. Here we performed whole-exome sequencing followed by gene-based tests on 4,298 PD cases 5,512 controls Asian ancestry. showed GBA1 SMPD1 were significantly associated with risk, replication a 5,585 5,642 controls. refined variant...
Cell adhesion is tightly regulated by specific molecular interactions and detachment from the extracellular matrix modifies proliferation survival. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) a protein-lipid complex with tumoricidal activity that also triggers tumor cell in vitro vivo, suggesting defining are perturbed cancer cells. To identify such interactions, membrane extracts were used Far-western blots was shown bind α-actinins; major F-actin cross-linking proteins...