A5035639631- Genetic Associations and Epidemiology
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Bipolar Disorder and Treatment
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Genetics and Neurodevelopmental Disorders
- Bioinformatics and Genomic Networks
- Autism Spectrum Disorder Research
- Renal and related cancers
- Autophagy in Disease and Therapy
- Reading and Literacy Development
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- Epigenetics and DNA Methylation
- Child and Adolescent Psychosocial and Emotional Development
- Diabetes and associated disorders
- PARP inhibition in cancer therapy
- Bone health and osteoporosis research
- Long-Term Effects of COVID-19
- Suicide and Self-Harm Studies
- Congenital heart defects research
- Ion channel regulation and function
Fujian Medical University
2021-2024
Chinese University of Hong Kong
2015-2024
Institute of Precision Mechanics
2024
University of Hong Kong
2019-2021
City University of Hong Kong, Shenzhen Research Institute
2021
Xiamen University
2014
Circular RNAs are a class of regulatory RNA transcripts, which ubiquitously expressed in eukaryotes. In the current study, we evaluate function novel circRNA derived from β-catenin gene locus, circβ-catenin. Circβ-catenin is predominantly localized cytoplasm and displays resistance to RNase-R treatment. We find that circβ-catenin highly liver cancer tissues when compared adjacent normal tissues. Silencing significantly suppresses malignant phenotypes vitro vivo, knockdown this reduces...
A series of pneumonia cases caused by 2019 novel coronavirus (2019-nCoV, also named COVID-19) are being reported globally. Based on recent publications,1–3 the most common symptoms in patients infected 2019-nCoV were fever and cough. However, incidence other clinical features differs different reports. To address this issue, we collected data from three reports1–3 compared accordingly. We found that leucopenia, diarrhoea studies showed a statistically significant difference (table 1). Among...
OBJECTIVE COVID-19 has become a major public health problem. There is good evidence that ACE2 receptor for SARS-CoV-2, and high expression of may increase susceptibility to infection. We aimed explore risk factors affecting infection prioritize drug repositioning candidates, based on Mendelian randomization (MR) studies lung expression. RESEARCH DESIGN AND METHODS conducted phenome-wide MR study diseases/traits blood proteins causally linked in GTEx. also explored candidates whose targets...
The Maillard reaction was established to reduce the sensitization of tropomyosin (TM) and arginine kinase (AK) from Scylla paramamosain, mechanism attenuated investigated. In present study, conditions were optimized for heating at 100 °C 60 min (pH 8.5) with arabinose. A low level allergenicity in mice shown by levels allergen-specific antibodies, more Th1 less Th2 cells cytokines produced associated transcription factors reacted allergen (mAllergen). tolerance potency demonstrated increased...
Glucagon-like peptide-1 (GLP-1) is a novel antidiabetic agent used in clinical practice. Recently, it was reported to exert renoprotective effect the human kidney-2 cells and kidneys of diabetic rats, which induced by one type GLP-1 analog, liraglutide, presence high glucose. However, most previous findings mainly focused on its indirect inhibiting advanced glycation end products. Here, besides glycemic control, we also demonstrated stimulatory role liraglutide promoting autophagy relieving...
Haliotis discus hannai tropomyosin (HTM), Alectryonella plicatula (ATM), and Mimachlamys nobilis (MTM) were reported as significant seafood allergens capable of eliciting severe allergic reactions. However, studies cross-reactivity epitope mapping among them are notably limited. This study discovered their property through inhibition IgG/IgE binding capacity promotion specific CD4+T-cell proliferation. For T-cell epitopes, 3, 4, 3 epitopes identified from the splenocytes mice immunized with...
Summary The outbreak of pneumonia caused by the 2019 Novel Coronavirus (2019-nCoV) was reported in Wuhan City, China. However, clinical symptoms varied different reports. Based on results inter-group difference test, we found that incidence diarrhea differed three recent As 2019-nCoV utilizes same cell entry receptor ACE2 as severe acute respiratory syndrome coronavirus (SARS-CoV) and tightly controls intestinal inflammation, to trace route infection mediated 2019-nCoV, used single-cell RNA...
Limited research has been conducted on the differences in allergenicity among Alectryonella plicatula tropomyosin (ATM), Haliotis discus hannai (HTM), and Mimachlamys nobilis (MTM) molluscs. Our study aimed to comprehensively analyze compare their immunoreactivity, sensitization, while simultaneously elucidating underlying molecular mechanisms involved. We assessed immune binding activity of TM utilizing 86 sera from allergic patients evaluated sensitization through two different types mouse...
Abstract Objectives COVID-19 has become a major public health problem. There is good evidence that ACE2 receptor for SARS-CoV-2, and high expression of may increase susceptibility to infection. We aimed explore risk factors affecting infection prioritize drug repositioning candidates, based on Mendelian randomization (MR) studies lung expression. Methods conducted phenome-wide MR study diseases/traits blood proteins causally linked in GTEx. also explored candidates whose targets overlapped...
Death-associated protein kinase 1 (DAPK1), a Ca2+/calmodulin-dependent serine/threonine kinase, mediates various neuronal functions, including cell death. Abnormal upregulation of DAPK1 is observed in human patients with neurological diseases, such as Alzheimer's disease (AD) and epilepsy. Ablation expression suppression activity attenuates neuropathology behavior impairments. However, whether regulates gene the brain, its profile implicated disorders, remains elusive. To reveal function...
Animal evidence and genetic studies suggest that HOMER1 (homer homolog 1) is involved in the etiology of suicidal behavior major depression disorder (MDD). However, most were performed Caucasians potentially functional role associated polymorphisms was seldom reported. The purpose this study to investigate association a polymorphism rs2290639 with suicide attempts (SA) MDD Hong Kong Chinese, then briefly elucidate polymorphism. NEO personality inventory, impulsiveness rating scales completed...
Spermatogenesis depends on an orchestrated series of developing events in germ cells and full maturation the somatic microenvironment. To date, majority efforts to study cellular heterogeneity testis has been focused single-cell gene expression rather than chromatin landscape shaping expression. advance our understanding regulatory programs underlying testicular cell types, we analyzed accessibility profiles more 25,000 from mouse testis. We showed that sequencing assay for...
N5-methylcytosine (m5C) methylation modification plays a crucial role in the epigenetic mechanisms underlying tumorigenesis, aggressiveness, and malignancy diffuse glioma. Our study aimed to develop novel prognostic risk-scoring system assess impact of m5C glioma patients. Initially, we identified two distinct clusters based on expression level regulators The Cancer Genome Atlas glioblastoma (TCGA-GBM) dataset. Differentially expressed genes (DEGs) between cluster groups were determined....
Abstract Dyslexia and developmental language disorders are important learning difficulties. However, their genetic basis remains poorly understood, most studies were performed on Europeans. There is a lack of genome-wide association (GWAS) literacy phenotypes Chinese as native English second (ESL) in population. In this study, we conducted GWAS 34 reading/language-related Hong Kong bilingual children (including both twins singletons; total N = 1046). We tests at the single-variant, gene,...
Recent studies indicated that supplementation of phosphatidylcholine has been found to be beneficial for psychiatric diseases and Diacylglycerol Kinase, Eta (DGKH) protein was involved in regulating the metabolism phosphatidic acid diacylglycerol. This study reported a case 16-year-old Chinese boy with bipolar hypomania symptoms receiving phosphatidylcholine, genetic risk variant DGKH gene performed an attempt provide explanation potential effect supplementation.We described disorder, who...
The allergen TM was purified from Alectryonella plicatula ; the sequence cloned. Linear epitopes played a major role in IgE-binding capacity of ATM. Nine linear were verified. L-ATM-2 key epitope to bind with IgE; L-ATM-5 and L-ATM-7 most conservative shellfish.