A5101722193- RNA modifications and cancer
- Immune Cell Function and Interaction
- Immune cells in cancer
- RNA and protein synthesis mechanisms
- CAR-T cell therapy research
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Telomeres, Telomerase, and Senescence
- Acute Myeloid Leukemia Research
- TGF-β signaling in diseases
- Liver physiology and pathology
- Advanced Breast Cancer Therapies
- Advances in Cucurbitaceae Research
- Cancer therapeutics and mechanisms
- Platelet Disorders and Treatments
- Wnt/β-catenin signaling in development and cancer
- Circular RNAs in diseases
- PARP inhibition in cancer therapy
- Lung Cancer Treatments and Mutations
- Autophagy in Disease and Therapy
- Chronic Lymphocytic Leukemia Research
- Stellar, planetary, and galactic studies
- Reproductive System and Pregnancy
- Advanced Glycation End Products research
Anhui Medical University
2015-2024
Second Hospital of Anhui Medical University
2018-2024
Huazhong University of Science and Technology
2024
Henan Agricultural University
2022-2024
Northeastern University
2023
University of Rochester
2018-2021
The First Affiliated Hospital, Sun Yat-sen University
2021
Sun Yat-sen University
2021
Zhujiang Hospital
2020
Southern Medical University
2020
Reading frame maintenance is critical for accurate translation. We show that the conserved eukaryotic/archaeal protein Mbf1 acts with ribosomal proteins Rps3/uS3 and eukaryotic Asc1/RACK1 to prevent frameshifting at inhibitory CGA-CGA codon pairs in yeast Saccharomyces cerevisiae. Mutations RPS3 allow implicate residues near mRNA entry site. Rps3 cooperate maintain reading of stalled ribosomes, while Asc1 also mediates distinct events result recruitment ribosome quality control complex...
Glucagon-like peptide-1 (GLP-1) is a novel antidiabetic agent used in clinical practice. Recently, it was reported to exert renoprotective effect the human kidney-2 cells and kidneys of diabetic rats, which induced by one type GLP-1 analog, liraglutide, presence high glucose. However, most previous findings mainly focused on its indirect inhibiting advanced glycation end products. Here, besides glycemic control, we also demonstrated stimulatory role liraglutide promoting autophagy relieving...
Abstract Introduction Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous cell population with the ability to suppress immune responses. MDSCs usually cluster in cancer, inflammation, and autoimmune diseases. Although there have been some studies on non‐Hodgkin lymphoma (NHL), correlation between peripheral levels of patients various subtypes B NHL clinical features prognosis remains inconclusive. This study aimed at issue. Methods 101 15 age‐matched healthy controls were included...
Background B-cell receptor–associated protein 31 (BAP31) has been recognized as a tumor-associated and largely shown to promote metastasis in variety of cancers. Cancer arises through multistep pathways, the induction angiogenesis is be rate-limiting step process tumor metastasis. Methods results This study explored effect BAP31 on colorectal cancer (CRC) by regulating microenvironment. First, exosomes from BAP31-regulated CRCs affected transition normal fibroblasts proangiogenic...
Myeloid-derived suppressor cells (MDSCs) comprise of a population cells, which suppress the innate and adaptive immune system via different mechanisms. MDSCs are accumulated under pathological conditions. The present study aimed to clarify role in systemic lupus erythematosus (SLE) patients. Consequently, level circulating M-MDSCs was significantly increased newly diagnosed SLE patients as compared healthy controls. An elevated positively correlated with disease severity an immunosuppressive...
Objectives: To explore the immunological abnormalities in patients with primary immune thrombocytopenia (ITP), and analyze its relationship treatment.Methods: Proportion of different cell subsets were detected peripheral blood 124 ITP at time points 45 normal controls by flow cytometry. The treatments included glucocorticoids, intravenous IgG as first-line treatment second-line drugs.Results: Elevated CD4/CD8 ratio decreased proportion NK CD4 + CD25 CD127low regulatory T cells (Tregs) found...
Ribosome stalls can result in ribosome collisions that elicit quality control responses, one function of which is to prevent frameshifting, an activity entails the interaction conserved yeast protein Mbf1 with uS3 on colliding ribosomes. However, full spectrum factors mediate frameshifting during unknown. To delineate such Saccharomyces cerevisiae , we used genetic selections for mutants affect from a known stall site, CGA codon repeats. We show general translation elongation factor eEF3 and...
Increased stemness is causally linked to the development of chemoresistance in cancers. B-cell receptor-associated protein 31 (BAP31) has been identified play an oncogenic role many types cancer. However, BAP31 5-fluorouracil (5-FU) chemosensitivity and colorectal cancer (CRC) still unknown. The aim this study was investigate biological function molecular mechanism regulating 5-FU stemness. correlation between expression examined using...
Abstract Background The underlying cause of relapsed and refractory (r/r) diffuse large B‐cell lymphoma (DLBCL) is usually related to apoptosis resistance antitumor drugs. recent years have provided lots evidence that tumor cells may undergo stress‐induced premature senescence (SIPS) in response chemotherapy, but how SIPS affects remains inconclusive. Methods Fifty‐two DLBCL patients, including 6 newly diagnosed (ND), 17 complete remissions (CR), 29 (r/r), were enrolled this study. We used a...
Abstract Background Acute lymphoblastic leukemia (ALL) and acute myeloid (AML) are the most common types of in adults with an overall poor prognosis. PD-1 alone or combined other immune checkpoint blockade is a promising research direction for treatment (AL) patients. However, clinical Implications aberrant expression peripheral CD4+ CD8+ T lymphocytes AML ALL patients assessing prognosis diseases, remains inconclusive. Methods In present study, we used flow cytometry to evaluate on surface...
Objective: Cellular senescence has been thought to be an important barrier tumor formation.Recent studies have shown that stressinduced premature (SIPS) can promote partial invasion, but how SIPS affects diffuse large B-cell lymphoma (DLBCL) remains inconclusive.This study aimed address issue. Materials and Methods:The immunophenotype of the LY8 cell line was measured with flow cytometry.SIPS induced by tert-butyl hydroperoxide (tBHP) detected β-galactosidase staining.Cell proliferation...
Abstract: Osimertinib has efficacy superior to that of standard epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) for the first-line treatment patients with EGFR-mutant advanced non-small cell lung cancer (NSCLC). However, treated osimertinib eventually acquire drug resistance. MET missense mutations have been demonstrated mediate resistance MET-TKIs, such as crizotinib. But role in mediating EGFR TKI is undefined. With increasing use next-generation sequencing (NGS)...
Background: Resistance to existing therapies is currently the main reason for treatment failure in refractory/relapsed B-NHL patients, and therapy-induced senescence (TIS) one of important mechanisms tumor drug resistance. Methods: Raji cells were transfected with human SENEX shRNA recombinant lentiviral vector (Si-SENEX) empty negative (NC) construct a stable transfection cell line knockdown SENEX. Effect SENEX-silencing on B-NHL-TIS formation, function cycle-related pathways was analyzed....
Seed size is an important agronomic trait in melons that directly affects the seed germination and subsequent seedling growth. However, genetic mechanism underlying melon has remained unclear. In present study, we employed Bulked-Segregant Analysis sequencing (BSA-seq) to identify a candidate region (∼1.35 Mb) on chromosome 6 corresponds size. This interval was confirmed by QTL mapping of three size-related traits from F2 population across environments. represented nine QTLs shared...
Based on the LAMOST spectroscopy and TESS time-series photometry, we have obtained a main-sequence star sample of $\delta$ Scuti $\gamma$ Doradus stars. The includes 1534 Sct stars, 367 Dor 1703 Sct$| \gamma$ 270 Dor$| \delta$ along with 105 '$\delta$ candidates' 32 '$\gamma$ candidates'. After correcting for projection effects, derived equatorial rotational velocity distribution stars compared it that normal distributions are extremely similar, only difference potentially due to variable...
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin around world. While R-CHOP has significantly improved patient outcomes, a subset of patients still poor outcome. Here, oncogenic roles cyclin dependent kinase 4/6 (CDK4/6)-Cyclin D (CCND) signaling axis in DLBCL and its potential mechanism were investigated to explore possibility targeting CDK4/6-CCND for therapy. The transcription levels, functional enrichment analysis, mutation prognostic values performed via Oncomine,...
Abstract Background: Acute lymphoblastic leukemia (ALL) and acute myeloid (AML) are the most common types of in adults with an overall poor prognosis. PD-1 alone or combined other immune checkpoint blockade is a promising research direction for treatment (AL) patients. However, clinical Implications aberrant expression peripheral CD4+ CD8+ T lymphocytes AML ALL patients assessing prognosis diseases, remains inconclusive. Methods: In present study, we used flow cytometry to evaluate on...