A5100345120- Immune cells in cancer
- interferon and immune responses
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Advancements in Battery Materials
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Advanced Battery Materials and Technologies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Advanced Battery Technologies Research
- Glioma Diagnosis and Treatment
- Medicinal Plants and Neuroprotection
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Acute Kidney Injury Research
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Inflammatory Biomarkers in Disease Prognosis
Chinese Academy of Sciences
2024-2025
Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic
2024-2025
South China Agricultural University
2025
Ministry of Agriculture and Rural Affairs
2025
Zhejiang University
2009-2024
First Affiliated Hospital Zhejiang University
2022-2024
Shanghai Institute of Nutrition and Health
2024
University of Chinese Academy of Sciences
2024
Jilin Medical University
2021-2024
Ministry of Education of the People's Republic of China
2024
Maintaining the stability of natural capital stock is an important basis for realizing regional sustainable development goals. Based on improved three-dimensional (3D) footprint family model, this study analyzes spatial and temporal evolution utilization water-carbon-ecological footprints in Central Plains Urban Agglomeration (CPUA) from 2010 to 2020. It considers water resources, carbon emissions ecological environment comprehensively, establishes evaluation system assess resource...
Microplastic (MP) pollution has raised global concerns, and biodegradable plastics have been recommended to replace conventional ones. The “plastisphere” considered a hotspot for the interactions among organisms environments, but differences in properties of soil microbial communities plastisphere MPs remain unclear. This situ experiment was conducted compare diversity structure bacterial community (polyethylene [PE]) (polylactic acid [PLA]) vegetable fields, orchards, paddy woodlands. It...
CTLA4, the immune checkpoint, has been widely reported to contribute evasion in anti-tumor activity. The inhibitors of CTLA4 provide a novel strategy improve outcome peripheral cancer, but their clinical effects are limited glioblastoma (GBM), thus comprehensive role needs be addressed.A total 471 GBM cases were enrolled this study from 5 cohorts. In our works, Cancer Genome Atlas (TCGA) cohort was divided into training set, and Chinese Glioma (CGGA), REMBRANDT, GSE84465 cohorts validation...
Abstract Introduction Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous cell population with the ability to suppress immune responses. MDSCs usually cluster in cancer, inflammation, and autoimmune diseases. Although there have been some studies on non‐Hodgkin lymphoma (NHL), correlation between peripheral levels of patients various subtypes B NHL clinical features prognosis remains inconclusive. This study aimed at issue. Methods 101 15 age‐matched healthy controls were included...
This study explores the role of succinate as a vaccine adjuvant, revealing its capacity to enhance neutrophil recruitment at immunization sites, which boosts B cell activation through receptor 1-interferon regulatory factor 5-B cell-activating (SUCNR1-IRF5-BAFF) signaling pathway. Results demonstrate succinate’s potential amplify vaccine-induced antibody responses, highlighting significance in immunological enhancement and offering new insights into adjuvant mechanisms action, particularly...
Enhanced macropinocytosis has been found in K-Ras mutant pancreatic cancer cells, through which albumin can massively enter into the K-Ras-driven suggesting its role serving as a macropinocytosis-intensifying drug delivery carrier. In present study, novel recombinant protein Fv-LDP-D3 and reconstituted analogue Fv-LDP-D3-AE were designed prepared. Fv is fragment of an anti-EGFR antibody, D3 domain III human serum (HSA), LDP apoprotein antitumor antibiotic lidamycin (LDM), AE extremely...
Background Macrophages, the major immune cells in glioma microenvironment, are closely related to tumor prognosis. Further studies needed investigate macrophages, which will be helpful fully understand role of it and early achieve clinical translation. Methods A total 1334 cases were enrolled this study from 3 databases. In our works, single cell cohorts GSE89567, GSE84465, Chinese Glioma Genome Atlas (CGGA) datasets used analyze key genes macrophage. The bulk sequencing data Cancer (TCGA)...
The excessive activation of interferon regulatory factor 7 (IRF7) promotes the development acute lung injury (ALI) caused by influenza A virus (IAV). However, deficiency IRF7 increases susceptibility to deadly IAV infection in both humans and mice. To test whether attenuation rather than abolishment activity local infectious sites could alleviate IAV-induced ALI, we established IAV-infected mouse model trachea/lung-tissue culture systems, designed two IRF7-interfering oligodeoxynucleotides,...
A previous study found that an AAAG-rich Oligodeoxynucleotide (ODN), designated as MS19, could lessen the acute lung inflammatory injury (ALII) in mice infected by influenza viruses. Bioinformatics analysis MS19 is consensus with binding site of interferon regulatory factor 5 (IRF5) elements pro-inflammatory genes. This established a septic peritonitis model Institute Cancer Research (ICR) Escherichia coli (E. coli), and prolonged survival down-regulated expression inducible nitric oxide...
Acute kidney injury (AKI) is a frequent complication of sepsis with hallmarks including inflammation and oxidative stress.
Neutrophils played a key role in the innate immune responses. Less is known about whether and how neutrophils recruited immunization sites affecting vaccine-induced antibody In process of evaluating efficacy an oil-in-water emulsion-formulated vaccine mice, we found that were rapidly massively to but barely detected draining lymph nodes. Interestingly, B cell-activating factor (BAFF) was abundantly expressed recruiting at very early stage. The initial neutrophil-derived BAFF firstly brought...
Abstract A high performance liquid chromatographic method was developed for the separation and determination of asiaticoside madecassoside isomers (asiaticoside-B madecassoside) in Centella asiatica products. The involved by reversed phase chromatography on an Atlantis T3 C18 column using water-acetonitrile-methyl tert-butyl ether (80:18:2:0.1, 0.1% acetic acid, volume) as mobile phase. asiaticoside-B were separated with resolution method. method's linearity, precision, recovery validated....
Abstract The implantation rate (IR) in assisted reproductive technologies such as vitro fertilization (IVF) and intracytoplasmic sperm injection is affected by many different factors age, quality of embryo, stage embryo development. This study aimed to investigate what extent the number previous failed transfer cycles an independent factor affecting IR. was a single-center, retrospective cohort consecutive series 6376 day-3 (ET) following IVF between January 2012 August 2018. None subjects...