A5034395433- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Acupuncture Treatment Research Studies
- Cell death mechanisms and regulation
- Neurological Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Pharmacological Effects of Natural Compounds
- Inflammasome and immune disorders
- Ginseng Biological Effects and Applications
- Immune cells in cancer
- Pancreatitis Pathology and Treatment
- Memory and Neural Mechanisms
- Pain Mechanisms and Treatments
- Immune Cell Function and Interaction
- Anesthesia and Pain Management
- Sirtuins and Resveratrol in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Neural dynamics and brain function
Ruijin Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Harbin Medical University
2022-2025
First Affiliated Hospital of Harbin Medical University
2022-2025
Guangdong Pharmaceutical University
2012-2025
Zhongshan Hospital of Xiamen University
2018-2024
First People's Hospital of Chongqing
2024
Guangxi Medical University
2024
National Natural Science Foundation of China
2023
International Data Group (Sweden)
2023
Under basal conditions, the interaction of cytosolic protein Keap1 (Kelch-like ECH-associated 1) with transcription factor nuclear factor-E(2)-related 2 (Nrf2) results in a low level expression cytoprotective genes whose promoter region contains antioxidant response element (ARE). Alkylation one or more 27 cysteine sulfhydryl groups human is proposed to lead Nrf2 accumulation, upregulation gene by ARE, and prevention degenerative diseases, such as cancer. Therefore, identification most...
Xenon attenuates on-going neuronal injury in both vitro and vivo models of hypoxic-ischaemic when administered during after the insult. In present study, we sought to investigate whether neuroprotective efficacy xenon can be observed before an insult, referred as ‘preconditioning’. a neuronal–glial cell coculture, preexposure for 2 h caused concentration-dependent reduction lactate dehydrogenase release from cells deprived oxygen glucose 24 later; xenon's preconditioning effect was abolished...
Respiratory syncytial virus (RSV) is the most important cause of severe, lower respiratory tract infections in infants, and RSV have been associated with chronic wheezing asthma during childhood. However, mechanism RSV-induced airway inflammation hyperresponsiveness (AHR) poorly understood. Furthermore, there are presently neither effective vaccines nor drugs available for prevention or treatment infections. In this study, we investigated effect plant extract resveratrol as a means...
Aerobic glycolysis is an important metabolic rewiring in cancer cells to promote glucose uptake and lactate production, targeting aerobic becomes a promising therapeutic approach for cancer. Here we reported that small polyphenol resveratrol exhibited profound anti-tumor efficacy on human ovarian Resveratrol markedly inhibited the proliferation, migration, invasion of A2780 SKOV3 cells, while impaired glycolysis, induced apoptosis these cells. Exposure increased expression activation AMPK...
Abstract Caspase-8 is an initiator of death receptor-induced apoptosis and inhibitor RIPK3-MLKL-dependent necroptosis. In addition, caspase-8 has been implicated in diseases such as lymphoproliferation, immunodeficiency, autoimmunity humans. Although auto-cleavage indispensable for activation, its physiological functions remain poorly understood. Here, we generated a mutant lacking E385 site knock-in mouse ( Casp8 ΔE385/ΔE385 ). cells were expectedly resistant to Fas-induced apoptosis,...
Sepsis-associated encephalopathy (SAE) is characterized by diffuse brain dysfunction, long-term cognitive impairment, and increased morbidity mortality. The current treatment for SAE mainly symptomatic; the lack of specific options a poor understanding underlying mechanism disease are responsible patient outcomes. Fgr member Src family tyrosine kinases involved in innate immune response, hematologic cancer, diet-induced obesity, hemorrhage-induced thalamic pain. This study investigated...
Perinatal hypoxia-ischemia causes significant morbidity and mortality. Xenon sevoflurane may be used as inhalational analgesics for labor. Therefore, the authors investigated potential application of these agents independently in combination to attenuate perinatal injury.Oxygen-glucose deprivation injury was induced pure neuronal or neuronal-glial cocultures 24 h after preconditioning with xenon and/or sevoflurane. Cell death assessed by lactate dehydrogenase release staining annexin...
Abnormal histone acetylation occurs during neuropathic pain through an epigenetic mechanism. Silent information regulator 1 (sir2 or SIRT1), a NAD-dependent deacetylase, plays complex systemic roles in variety of processes deacetylating acetylated and other specific substrates. But the role SIRT1 is not well established yet. The present study was intended to detect content activity, nicotinamide (NAM) adenine dinucleotide (NAD) spinal cord using immunoblotting mass spectroscopy over time...
Abstract Background Diabetes mellitus (DM) and chronic cerebral hypoperfusion(CCH)are both risk factors for cognitive impairment. However, whether DM CCH can synergistically promote impairment the related pathological mechanisms remain unknown. Methods To investigate effect of on function, rats fed with high-fat diet (HFD) injected low-dose streptozotocin (STZ) followed by bilateral common carotid artery occlusion (BCCAO) were induced to mimic in vivo mouse BV2 microglial cells exposed...
Abstract Necroptosis, which is mediated by RIP1/RIP3/MLKL (receptor-interacting protein kinase 1/receptor-interacting 3/mixed lineage domain-like protein) signaling, a critical process in the development of acute ischemic stroke. However, it unclear precisely how necroptosis promotes pathogenesis In this experimental study mice, we investigated loss-of-function RIP1 kinase-dead RIP3-deficiency and MLKL-deficiency mice could be protected against cerebral injury after Insoluble RIP1, RIP3,...
Upregulation of cytoprotective and detoxifying enzyme expression by small molecules is emerging as an important means preventing carcinogenesis well other diseases. A proposed target these agents the Kelch-like ECH-associated protein 1 (Keap1). The vast majority contain electrophilic moieties, which react with a subset 27 cysteines human Keap1. Modification to result in nuclear accumulation transcription factor NF-E2-related factor-2 (Nrf2), Keap1 binding partner, leading upregulation...
Abstract Isoliquiritigenin (2′,4′,4-trihydroxychalcone; ILG), a chalcone found in licorice root and many other plants, has shown potential chemopreventive activity through induction of phase II enzymes such as quinone reductase-1 murine hepatoma cells. In this study, the vivo metabolism ILG was investigated rats. addition, glucuronides ILG-glutathione adducts were observed human hepatocytes livers from rats treated with ILG. detected both plasma rat liver tissues. full-term cancer...
Background: The underlying mechanisms of isoflurane neurotoxicity in the developing brain remain unclear. Ferroptosis is a recently characterized form programmed cell death distinct from apoptosis or autophagy, by iron-dependent reactive oxygen species (ROS) generation secondary to failure glutathione-dependent antioxidant defenses. In present study we tested vitro hypothesis that ferroptosis contributes neurotoxicity. Methods:Embryonic primary cortical neuronal cultures (day-in-vitro 7,...
Soil microorganisms are the key driver of geochemical cycle in forest ecosystem. Changes litter and roots can affect soil microbial activities nutrient cycling; however, impact this change on community composition function remain unclear. Here, we explored effects root manipulations [control (CK), doubled input (DL), removal (NL), exclusion (NR), a combination (NI)] bacterial fungal communities functional groups during 2-year field experiment, using illumina HiSeq sequencing coupled with...
Objective:Evidences demonstrate that postoperative residual neuromuscular blockade (rNMB) is a primary and frequent anesthetic risk factor for complications. This study was designed to mitigate the paucity of data regarding occurrence degree rNMB in real-life setting.Methods:This prospective, multicenter, anesthetist-blind, observational enrolled 1571 Chinese adults undergoing elective open or laparoscopic abdominal surgery lasting ≤4 hours from 32 hospitals across China. The patients...
Abstract Extramammary Paget's disease (EMPD) is a rare cutaneous malignant neoplasm. The genetic alterations underlying its pathogenesis have less been described. Therefore, we analyzed the possible mutations in KRAS , HRAS NRAS BRAF ARAF RAF1 PIK3CA AKT1 CTNNB1 and APC genes as well methylation expression of CDH1 144 EMPD cases 42 matched normal skin tissues. A distinct mutation profile was identified EMPDs with 27 (19%) mutant for RAS RAF 50 (35%) harboring oncogenic . Moreover, mutually...
Demand is increasing for safer inhalational anesthetics use in pediatric anesthesia. In this regard, researchers have debated whether isoflurane more toxic to the developing brain than desflurane. present study, we compared effects of postnatal exposure with those desflurane on long-term cognitive performance and investigated role Akt/GSK3 β signaling pathway. Postnatal day 6 (P6) mice were exposed either or desflurane, after which phosphorylation levels learning memory assessed at P8 P31....
Abstract Background Macrophages play significant roles in innate immune responses and are heterogeneous cells that can be polarized into M1 or M2 phenotypes. PRMT2 is one of the type I protein arginine methyltransferases involved inflammation. However, role M1/M2 macrophage polarization remains unclear. Our study revealed effect mechanism polarization. Methods Bone marrow-derived macrophages (BMDMs) were to state by LPS plus murine recombinant interferon-γ (IFN-γ) interleukin-4 (IL-4)....