A5100382569- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Heat shock proteins research
- Dendrimers and Hyperbranched Polymers
- Chemical Synthesis and Analysis
- Lanthanide and Transition Metal Complexes
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- ATP Synthase and ATPases Research
- Advanced Surface Polishing Techniques
- Immune cells in cancer
- Computational Drug Discovery Methods
- Photodynamic Therapy Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Response and Inflammation
- Biofuel production and bioconversion
- Supramolecular Self-Assembly in Materials
- Fluorine in Organic Chemistry
Sichuan University
2016-2025
West China Hospital of Sichuan University
2010-2025
State Key Laboratory of Biotherapy
2019-2025
Peking University
2013-2024
Peking University Cancer Hospital
2024
Anhui University of Finance and Economics
2024
Huzhou University
2024
Guangdong University of Technology
2020-2024
Shenzhen Institute for Drug Control
2022-2024
Fudan University Shanghai Cancer Center
2018-2023
Abstract Pancreatic cancer is an aggressive disease with multiple biochemical and genetic alterations. Thus, a single agent to hit one molecular target may not be sufficient treat this disease. The purpose of study identify novel Hsp90 inhibitor disrupt protein-protein interactions its cochaperones for down-regulating many oncogenes simultaneously against pancreatic cells. Here, we reported that celastrol disrupted Hsp90-Cdc37 interaction in the superchaperone complex exhibit antitumor...
Abstract In this work, we have developed a new class of aggregation‐induced emission (AIE) active compounds, in which three electron‐donating diphenylamine, phenothiazine, or carbazole groups are connected to the 1, 4‐positions benzene through bis(α‐cyano‐4‐diphenylaminostyryl) conjugation bridges form triarylamine quadrupolar derivatives ( 3 – c ). Their one‐ and two‐photon absorption properties been investigated. The (2PA) cross sections measured by open‐aperture Z‐scan technique were...
Multifunctional theranostic nanoplatforms (NPs) in response to environment stimulations for on-demand drug release are highly desirable. Herein, the near-infrared (NIR)-absorbing dye, indocyanine green (ICG), and antitumor drug, doxorubicin (DOX), were efficiently coencapsulated into thermosensitive liposomes based on natural phase-change material. Folate conjugated gadolinium (Gd) chelate-modified liposome shells enhance active targeting magnetic resonance performance of NPs while...
Yes-associated protein (YAP) has been identified as a key driver for epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistance. Inhibition of YAP expression could be potential therapeutic option treating non-small-cell lung cancer (NSCLC). Herein, nanococktail strategy is proposed by employing amphiphilic and block-dendritic-polymer-based nanoparticles (NPs) targeted co-delivery EGFR-TKI gefitinib (Gef) YAP-siRNA to achieve drug/gene/photodynamic therapy. The resulting...
Nanoprobes that offer both fluorescence imaging (FI) and magnetic resonance (MRI) can provide supplementary information hold synergistic advantages. However, synthesis of such dual-modality probes simultaneously exhibit tunability functional groups, high stability, great biocompatibility desired results remains challenging. In this study, we used an amphiphilic block polymer from (ethylene glycol) methyl ether methacrylate (OEGMA) N-(2-hydroxypropyl) methacrylamide (HPMA) derivatives as a...
The development of effective and safe tumor nanotheranostics remains a research imperative. Herein, microenvironment (TME)-responsive Fe(III)-porphyrin (TCPP) coordination nanoparticles (FT@HA NPs) were prepared using simple one-pot method followed by modification with hyaluronic acid (HA). FT@HA NPs specifically accumulated in CD44 receptor-overexpressed tissues through the targeting property HA upon endocytosis cells. After cell internalization, intracellular acidic microenvironments high...
Tomato (Solanum lycopersicum) is one of the highest-value vegetable crops worldwide. Understanding genetic regulation primary metabolite levels can inform efforts aimed toward improving nutrition commercial tomato cultivars, while maintaining key traits such as yield and stress tolerance. We identified 388 suggestive association loci (including 126 significant loci) for 92 metabolic including flavor-related by genome-wide study from 302 accessions in two different environments. Among them,...
The application of nanomedicines for glioblastoma (GBM) therapy is hampered by the blood-brain barrier (BBB) and dense tissue. To achieve efficient BBB crossing deep GBM penetration, this work demonstrates a strategy active transcellular transport mitochondrion-disturbing nanomedicine, pGBEMA
Dendrimers have emerged as multifunctional carriers for targeted drug delivery, gene delivery and imaging. Improving the functional versatility at surface carrying multiple conjugation reactions is becoming vital. Typically, generation four polyamidoamine (G4-PAMAM) dendrimers bear ∼64 symmetrical end groups, often requiring different spacers to conjugate various groups (drugs targeting moities), increasing synthetic steps. In present study, a simple one-step synthesis convert each group of...
The combination of chemotherapeutic drugs with different pharmacological action has emerged as a promising therapeutic strategy in the treatment cancers. Present study examines antitumor potential paclitaxel (PTX) and etoposide (ETP)-loaded PLGA nanoparticles for osteosarcoma. resulting drug-loaded NP exhibited nanosize dimension uniform spherical morphology. sustained release profile both PTX ETP throughout period without any sign initial burst release. combinational enhanced cytotoxic...
The research of hydrogels has been increasingly focused on designing an effective energy dissipation structure in recent years. Here, we report a kind novel supramolecular cross-linker, which was formed by self-assembling amphiphilic block copolymers with guest groups at the end and vinyl-functionalized cyclodextrin (CD) through host–guest interaction. These cross-linkers could dissipate effectively since they combined multiple sacrificial mechanisms across multiscales physical interactions....
To promote operational intelligence, improve surface quality, and reduce manpower dependence, a novel high-bandwidth end-effector with active force control for robotic polishing was proposed. Using this as mini robot, macro-mini robot processing constructed, in which the macro provides posture during operations, whereas mini-robot constant control. By minimizing inertia along spindle configuration, obtains bandwidth of 200 Hz. Through series comparative experiments different contact forces...
Abstract Purpose: We sought to examine the synergistic antipancreatic cancer effect by simultaneously targeting hypoxic cells with heat-shock protein 90 (HSP90) inhibitor and blockade of energy production. Experimental Design: The anticancer effects an HSP90 (geldanamycin) in pancreatic were investigated hypoxia normoxia. A hexokinase II inhibitor, 3-broma-pyruvate (3BrPA), was evaluated for selective glycolysis inhibition as a sensitizer against cancer. client degradation monitored Western...
In this paper, a new polyhedral oligomeric silsesquioxane containing phenol group (POSS-Phenol) is prepared through the Michael addition reaction, which added to synthesis of phenolic resin as functional monomer. Infrared spectroscopy (IR) used demonstrate chemistry structure synthesized POSS modified resin. After introducing into resole, comprehensive study conducted reveal effects on thermal degradation First, behaviors neat and are carried out by thermogravimetric analysis (TGA). Then,...
In this study, a novel ASGP-R targeted contrast agent has been developed for liver cancer diagnosis, which exhibits high imaging efficacy and great biosafety, holding promise as MRI of human cancer.
Strategically targeting lymph nodes (LNs) to orchestrate the initiation and regulation of adaptive immune responses is one most pressing challenges in context vaccination. Herein, a series polymer-TLR agonist conjugates (PTACs) developed investigate impact dendritic-topological characteristics on their LN activity vivo, molecular weight (MW) pharmacokinetics support homing. Notably, dendritic 6-arm PTAC with MW 60 kDa (6A-PTAC-60k) rapidly delivered cargo draining LNs after administration...
The synthesis, in vitro activities, and pharmacokinetics of a series azepanone-based inhibitors the cysteine protease cathepsin K (EC 3.4.22.38) are described. These compounds show improved configurational stability C-4 diastereomeric center relative to previously published five- six-membered ring ketone-based inhibitor series. Studies this have led identification 20, potent, selective human (Ki = 0.16 nM) as well 24, potent both 0.0048 rat (Ki,app 4.8 K. Small-molecule X-ray...