A5012606774- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Pharmacological Effects of Natural Compounds
- Molecular spectroscopy and chirality
- Analytical Chemistry and Chromatography
- Advanced NMR Techniques and Applications
- Phytoestrogen effects and research
- Hops Chemistry and Applications
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Dental materials and restorations
- Bioactive Natural Diterpenoids Research
- NMR spectroscopy and applications
- Estrogen and related hormone effects
- Dental Erosion and Treatment
- Plant biochemistry and biosynthesis
- Traditional Chinese Medicine Analysis
- Acoustic Wave Resonator Technologies
- Solid-state spectroscopy and crystallography
- Plant-based Medicinal Research
- Phytochemical Studies and Bioactivities
- Biological Activity of Diterpenoids and Biflavonoids
- Menopause: Health Impacts and Treatments
University of Illinois Chicago
2016-2025
Chinese Academy of Sciences
2000-2025
Czech Academy of Sciences, Institute of Biophysics
2024-2025
National Science Center
2025
Institute of Art
2025
University of Science and Technology of China
2023-2025
University of Illinois Urbana-Champaign
2011-2025
Micro & Nano Research Institute
2024
Zhejiang University
1994-2024
Monash University
2024
The spread of SARS-CoV-2 and ongoing COVID-19 pandemic underscores the need for new treatments. Here we report that cannabidiol (CBD) inhibits infection in cells mice. CBD its metabolite 7-OH-CBD, but not THC or other congeneric cannabinoids tested, potently block replication lung epithelial cells. acts after viral entry, inhibiting gene expression reversing many effects on host transcription. part by up-regulating IRE1α RNase endoplasmic reticulum (ER) stress response interferon signaling...
Extracts of the rhizome black cohosh [Actaea racemosa L., formerly called Cimicifuga (L.) Nutt.] were evaluated for potential mechanisms action in alleviation menopausal hot flashes. Ovariectomized Sprague−Dawley rats administered a 40% 2-propanol extract [4, 40, and 400 mg/(kg·day)] by gavage 2 weeks with or without estradiol [50 μg/(kg·day)] to determine if could act as an estrogen antiestrogen on basis increase uterine weight vaginal cellular cornification. No effects observed...
Scope Women seeking alternatives to hormone‐replacement therapy for menopausal symptoms often try botanical dietary supplements containing extracts of hops ( Humulus lupulus L.). Hops contain 8‐prenylnaringenin (8‐PN), a potent phytoestrogen, the related flavanones 6‐prenylnaringenin and isoxanthohumol (IX), prenylated chalcone xanthohumol (XN). Methods results After chemically biologically standardizing an extract spent these marker compounds, escalating dose study was carried out in women...
ABSTRACT The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD), a compound produced by cannabis plant, inhibits SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, but not congeneric cannabinoids, potently block replication in lung epithelial cells. acts after cellular infection, inhibiting viral gene expression reversing many effects on host transcription. induces interferon up-regulates antiviral signaling pathway. A cohort human...
Serotonin receptor (5-HT7) binding assay-directed fractionation of a methanol extract the dried roots Angelica sinensis led to isolation and identification 21 compounds including new phenolic ester, angeliferulate (1), three phthalides, 10-angeloylbutylphthalide (2), sinaspirolide (3), ansaspirolide (4), along with 17 known compounds, p-hydroxyphenethyl trans-ferulate (5), Z-ligustilide (6), Z-butylidenephthalide (7), senkyunolide I (8), Z-6-hydroxy-7-methoxydihydroligustilide (9),...
This study demonstrates how regio- and diastereo-isomers with near-identical NMR spectra can be distinguished unambiguously assigned using quantum mechanical driven 1H iterative Full Spin Analysis (HiFSA). The method is illustrated four natural products, the flavonolignans silybin A, B, isosilybin which exhibit extremely similar coupling patterns chemical shift differences well below commonly reported level of accuracy 0.01 ppm. HiFSA approach generated highly reproducible fingerprints that...
The increased cancer risk associated with hormone therapies has encouraged many women to seek non-hormonal alternatives including botanical supplements such as hops (Humulus lupulus) and licorice (Glycyrrhiza spec.) manage menopausal symptoms. Previous studies have shown estrogenic properties for hops, likely due the presence of 8-prenylnarigenin, chemopreventive effects mainly attributed xanthohumol. Similarly, a combination been reported various Glycyrrhiza species. major goal current...
Although proanthocyanidins (PACs) modify dentin, the effectiveness of different PAC sources and correlation with their specific chemical composition are still unknown. This study describes profiling natural PAC-rich extracts from 7 plants using ultra high pressure/performance liquid chromatography (UHPLC) to determine overall these and, in parallel, comprehensively evaluate effect on dentin properties. The total polyphenol content was determined (as gallic acid equivalents) Folin-Ciocalteau...
The present study demonstrates the importance of adequate precision when reporting δ and J parameters frequency domain 1H NMR (HNMR) data. Using a variety structural classes (terpenoids, phenolics, alkaloids) from different taxa (plants, cyanobacteria), this develops rationales that explain enhanced in spectroscopic analysis rationalizes need for Δδ ΔJ values at 0.1–1 ppb 10 mHz level, respectively. Spectral simulations paired with iteration are shown to be essential tools complete spectral...
Oligomeric proanthocyanidins (OPACs) are potent and renewable natural bioactives possible to be refined into chemically standardized mixtures for biological applications. Herein, we found that multiscale interactions of OPACs with the dentin matrix create tight biointerfaces hydrophobic methacrylate adhesives on wet surfaces. An enriched mixture OPACs, a known phytochemical profile, was produced from grape seed crude extract ( Vitis vinifera; [e-GSE]) applied matrices determine changes...
Proanthocyanidins (PACs) are secondary plant metabolites that mediate nonenzymatic collagen cross-linking and enhance the properties of based tissue, such as dentin. The extent nature is influenced by composition specific chemical structure bioactive compounds present in certain PAC-rich extracts. This study investigated effect molecular weight stereochemistry polyphenol on two important dentin, biomechanics, biostability. For that, purified phenols, a phenolic acid, some its derivatives...