A5024522325- Dental materials and restorations
- Dental Erosion and Treatment
- Endodontics and Root Canal Treatments
- Laser Applications in Dentistry and Medicine
- Biochemical effects in animals
- Oral microbiology and periodontitis research
- Bone and Dental Protein Studies
- Natural product bioactivities and synthesis
- Cultural Heritage Materials Analysis
- Collagen: Extraction and Characterization
- Chromatography in Natural Products
- Copper Interconnects and Reliability
- Metal and Thin Film Mechanics
- Orthodontics and Dentofacial Orthopedics
- Botulinum Toxin and Related Neurological Disorders
- Bioactive Compounds and Antitumor Agents
- Food Quality and Safety Studies
- Pain Management and Placebo Effect
- Medicinal Plants and Bioactive Compounds
- Dental Research and COVID-19
- Biological Stains and Phytochemicals
- Phytochemicals and Antioxidant Activities
- Dental Implant Techniques and Outcomes
- Biochemical Analysis and Sensing Techniques
- Surface Modification and Superhydrophobicity
University of Iowa
2024
University of Illinois Chicago
2016-2022
Marquette University
2020
Oligomeric proanthocyanidins (OPACs) are potent and renewable natural bioactives possible to be refined into chemically standardized mixtures for biological applications. Herein, we found that multiscale interactions of OPACs with the dentin matrix create tight biointerfaces hydrophobic methacrylate adhesives on wet surfaces. An enriched mixture OPACs, a known phytochemical profile, was produced from grape seed crude extract ( Vitis vinifera; [e-GSE]) applied matrices determine changes...
The structurally complex oligomeric proanthocyanidins (OPACs) are promising biomimetic agents, capable of strengthening the macromolecular backbone teeth via intermolecular and intermicrofibrillar cross-linking. This study establishes analytical methods determining absolute configuration catechin-type monomeric units underivatized OPACs. preserves capacity their biological evaluation, aimed at understanding inevitably stereospecific interactions between OPACs dentin collagen. Guided by...
A dentin biomodification strategy with selective proanthocyanidin (PAC)–enriched extracts reinforces and dentin-resin interfaces. Enrichment of the according to degree polymerization allows exploration bioactive principles PACs structure-activity relationships. This study investigated sustained matrix bioadhesion 2 fractions consisting exclusively B-type PAC dimers or without a single galloyl motif (specifically, DIMER G NG ) their precursor material, enriched grape seed extract (e-GSE;...
Aimed at exploring the dentin biomodification potential of proanthocyanidins (PACs) for development dental biomaterials, this study reports phytochemical and evaluation nine B-type PACs from grape seed extract (GSE). Out seven isolated dimers (1–7), four new compounds (2, 3, 5, 6) involved relatively rare ent-catechin or ent-epicatechin monomeric flavan-3-ol units. Low-temperature NMR analyses conducted along with phloroglucinolysis electronic circular dichroism enabled unequivocal...
The present study elucidated the structures of three A-type tri- and tetrameric proanthocyanidins (PACs) isolated from Cinnamomum verum bark to level absolute configuration determined their dental bioactivity using two therapeutically relevant bioassays. After selecting a PAC oligomer fraction via biologically diverse bioassay-guided process, in tandem with centrifugal partition chromatography, phytochemical studies led isolation oligomers that represent main bioactive principles C. verum:...
PURPOSE To investigate the long-term effect of 0.05% or 0.1% caffeic acid phenethyl ester (CAPE) on dentin matrix stability and hybrid layer stability, using an etch-and-rinse (Adper Scotchbond Multipurpose/ASB) a self-etch adhesive (Clearfil SE Bond/CSE). MATERIALS AND METHODS Dentin specimens were assigned to five groups: CAPE, green tea (GT), controls distilled water (DW) dimethyl sulfoxide (DMSO). Following immersion for 1 h, modulus elasticity (ME) mass change (MG) determined at 3...
Abstract Plant‐derived proanthocyanidins (PACs) mediate physicochemical modifications to the dentin extracellular matrix (ECM). The structure–activity relationships of PACs remain largely unknown, mostly due varied complex composition crude extracts, as well challenges purification and mechanistic assessment. To assess role galloylated significant contributors high yet unstable biomodification activity ECM, we removed galloyl moieties (de‐galloylation) via enzymatic hydrolysis from three...
Grape seed extract contains a complex mixture of proanthocyanidins (PACs), plant biopolymer used as biomaterial to improve reparative and preventive dental therapies. Co-polymerization PACs with type I collagen mechanically reinforces the dentin extracellular matrix. This study assessed biocompatibility from grape on pulp stem cells (DPSCs) in model simulating leaching through cavity. The aim was determine (galloylated vs. non-galloylated) within that are most compatible tissue.Human...