A5085618081- Natural product bioactivities and synthesis
- Cholinesterase and Neurodegenerative Diseases
- Phytochemistry and Biological Activities
- Chemical synthesis and alkaloids
- Fungal Biology and Applications
- Plant biochemistry and biosynthesis
- Traditional Chinese Medicine Analysis
- Medicinal Plants and Bioactive Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Microbial Natural Products and Biosynthesis
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Plant Toxicity and Pharmacological Properties
- Metabolomics and Mass Spectrometry Studies
- Chromatography in Natural Products
- Marine Sponges and Natural Products
- Phytochemical compounds biological activities
- Bioactive Compounds and Antitumor Agents
- Sesquiterpenes and Asteraceae Studies
- Traditional Chinese Medicine Studies
- Allelopathy and phytotoxic interactions
- Medicinal Plant Pharmacodynamics Research
- Electrocatalysts for Energy Conversion
- Traditional and Medicinal Uses of Annonaceae
- Computational Drug Discovery Methods
Zhejiang University
2023-2025
China University of Petroleum, Beijing
2025
University of Illinois Chicago
2020-2024
Army Medical University
2022-2023
Yunnan Normal University
2008-2023
Zhejiang Lab
2023
Chengdu Medical College
2023
Fudan University
2013-2022
State Administration of Traditional Chinese Medicine of the People's Republic of China
2016
Hunan University
2016
Ten new lycodine-type alkaloids, named casuarinines A–J (1–10), along with eight known analogues (11–18), were isolated from the whole plant of Lycopodiastrum casuarinoides. The structures established by spectroscopic methods and chemical transformations. Casuarinines A–D (1–4) J (10) are common lycodine alkaloids possessing four connected six-membered rings, while tricyclic E–H (5–8) piperidine ring cleavage products. In particular, casuarinine I (9) has an unprecedented five-membered...
In recent years, Salmonella infection is a major global public health concern, particularly in food safety. This study analyzed the genomes of 102 strains isolated between 2016 and 2023 from food, foodborne disease patients, poisoning incidents, focusing on their molecular characteristics, antibiotic resistance genes (ARGs), virulence genes. S. enterica serovar Enteritidis (37.3%) Typhimurium (21.6%, including its monophasic variant 1,4,[5],12:i:-) were main among 22 serotypes. Multilocus...
Despite significant advances in analytical methods, the quality evaluation and adulteration detection of chemically complex traditional Chinese medicines continues to be a major challenge. We developed custom diffusion-ordered spectroscopy (DOSY) approach for qualitative analysis precious Calculus Bovis (CB) its adulterants. Using Artificial as an example, we focused on effects NMR spectrometers, solvent viscosity, matrices, matrix concentration, temperature separation efficiency DOSY. The...
Five new preussomerin analogues, ymf 1029A (1), B (2), C (3), D (4), and E (5), were isolated from the liquid cultures of an unidentified freshwater fungus YMF 1.01029, along with four known compounds, (6), (7), (4RS)- 4,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one (8), 4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2H)-one (9). The structures metabolites determined by analysis NMR MS data analogy for bis-spirobisnaphthalene preussomerins. In vitro immersion experiments showed that these displayed...
Three novel 7,8-seco-lycopodane-derived 8,5-lactones (annotinolides A–C, 1–3) were isolated from Lycopodium annotinum. Their structures elucidated by spectroscopic methods and single-crystal X-ray diffraction. Compound 1 possesses an unusual cyclopropane ring constructed through a hitherto unknown C-6/C-12 bond. 2 represents the first alkaloid with rare cyclobutane formed new C-12/C-15 linkage, while C-8/C-15 bond remains. 3 contains unprecedented 12-spiro-9,12-γ-lactone moiety. plausible...
Abstract Background Determination of batch-to-batch consistency botanical drugs (BDs) has long been the bottleneck in quality evaluation primarily due to chemical diversity inherent BDs. This presents an obstacle achieving comprehensive standardization for Basically, a single detection mode likely leads substandard analysis results as different classes structures always possess distinct physicochemical properties. Whereas representing workaround multi-target using multi-modal data, data...
Monoterpenoids are integral to the chemical composition of widely used adaptogenic dietary supplement Rhodiola rosea. The present study expands space and stereochemical information about these taxon-specific constituents from isolation characterization five geraniol-derived glucosides, 1–5. While 1 2 exhibited almost identical NMR spectra shared same 2D structure ascribed 4-hydroxygeraniolglucoside previously described as rosiridin, NMR-based Mosher ester method revealed enantiomeric nature...
NMR- and MS-guided metabolomic mining for new phytoconstituents from a widely used dietary supplement, Rhodiola rosea, yielded two (+)-myrtenol glycosides, 1 2, cuminol 3 4, along with three known analogues, 5-7. The structures of the compounds were determined by extensive spectroscopic data analysis. Quantum mechanics-driven 1H iterative full spin analysis (QM-HiFSA) decoded spatial arrangement methyl groups in as well other features not recognizable conventional methods, including higher...