A5042300113- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Biological Activity of Diterpenoids and Biflavonoids
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Phytochemical compounds biological activities
- Plant biochemistry and biosynthesis
- Sesquiterpenes and Asteraceae Studies
- Natural Compound Pharmacology Studies
- Traditional Chinese Medicine Analysis
- Traditional and Medicinal Uses of Annonaceae
- Chemical synthesis and alkaloids
- Bioactive natural compounds
- Bioactive Natural Diterpenoids Research
- Bioactive Compounds and Antitumor Agents
- Plant-derived Lignans Synthesis and Bioactivity
- Ginkgo biloba and Cashew Applications
- Food Quality and Safety Studies
- Plant Pathogens and Fungal Diseases
- Natural Compounds in Disease Treatment
- Ziziphus Jujuba Studies and Applications
- Cholinesterase and Neurodegenerative Diseases
- Polysaccharides and Plant Cell Walls
Ningxia University
2025
Fudan University
2015-2024
Guangxi University of Chinese Medicine
2021
Lishui Academy of Agricultural Sciences
2015
Beth Israel Deaconess Medical Center
2011-2013
Harvard University
2011-2013
First Affiliated Hospital of GuangXi Medical University
2007
Guangxi Medical University
2007
Ten new lycodine-type alkaloids, named casuarinines A–J (1–10), along with eight known analogues (11–18), were isolated from the whole plant of Lycopodiastrum casuarinoides. The structures established by spectroscopic methods and chemical transformations. Casuarinines A–D (1–4) J (10) are common lycodine alkaloids possessing four connected six-membered rings, while tricyclic E–H (5–8) piperidine ring cleavage products. In particular, casuarinine I (9) has an unprecedented five-membered...
Background and Aims Saccharomyces boulardii (Sb) can protect against intestinal injury tumor formation, but how this probiotic yeast controls protective mucosal host responses is unclear. Angiogenesis an integral process of inflammatory in bowel diseases (IBD) required for remodeling during restitution. The aim study was to determine whether Sb alters VEGFR (vascular endothelial growth factor receptor) signaling, a central regulator angiogenesis. Methods HUVEC were used examine the effects...
Nine unexpected new flavonol glycoside cyclodimers in the truxinate (1-7, biginkgosides A-G, respectively) or truxillate [biginkgosides H (8) and I (9)] forms were isolated as minor components from extract of Ginkgo biloba leaves. The dimers possess an unusual cyclobutane ring formed by a [2+2]-cycloaddition between two symmetric (for compounds 1-5 7-9) nonsymmetric 6) coumaroyl glucorhamnosides. A plausible biosynthetic pathway for these based on frontier molecular orbital theory...
Fourteen new ent-abietane-type diterpenoids, sessilifols A–N (1–14), and three related norditerpenoids (15–17) were isolated from Chloranthus sessilifolius. The absolute configurations determined by single-crystal X-ray diffraction analysis, the modified Mosher's method, and/or observed Cotton effects in their electronic circular dichroism spectra. Sessilifols A (1) B (2) possess an uncommon five-membered C-ring rearranged oxidative cleavage of C-13/C-14 bond abieta-7,13-diene followed...
Abstract Two rare rearranged cuparane‐type sesquiterpenoid C‐10 epimers [beshanzuenones A ( 1 ) and B 2 )] two bisabolane‐type spirolactones C 3 D 4 featuring an unusual [6/6/5]‐fused tricyclic ring system were isolated from the shed trunk barks of Abies beshanzuensis , one critically endangered plant species in world. The structures these four new enone‐containing sesquiterpenoids determined by spectroscopic analyses single‐crystal X‐ray diffraction or electronic circular dichroism (ECD)...
Twelve new ent-abietane diterpenoids, chlorabietins A-L (), were isolated from the roots of Chloranthus oldhamii. Their structures and absolute configurations determined by extensive spectroscopic analyses, X-ray diffraction, experimental/calculated electronic circular dichroism (ECD) spectroscopy. Among isolates, D () E are first two naturally occurring 8-spiro-fused 9,10-seco-ent-abietanes containing an unexpected cis-fused A/B ring system. Chlorabietin F is a rare chinane-type diterpenoid...
Three unprecedented phloroglucinol-diterpene adducts, chlorabietols A-C (1-3), were isolated from the roots of rare Chloranthaceae plant Chloranthus oldhamii. They represent a new class compounds, featuring an abietane-type diterpenoid coupled with different alkenyl phloroglucinol units by forming 2,3-dihydrofuran ring. Their structures elucidated detailed spectroscopic analysis, molecular modeling studies, and electronic circular dichroism calculations. Compounds 1-3 showed inhibitory...
Six new (leonurusoleanolides E–J, 1–6) and five known (7–11) nortriterpenoids were isolated characterized from the dried fruits of Leonurus japonicus. They all contain a distinctive 19(18→17)-abeo-28-noroleanane-type spirocylclic skeleton with trans or cis acyl substituent at C-3 C-23. Similar to previously leonurusoleanolides A/B (7/8) C/D (9/10), compounds 1/2 3/4 also found exist as equilibrium mixtures isomers. The pure evaluated for their cytotoxicity against small panel human cancer...
Abstract Nineteen compounds mainly including pyrrole‐containing alkaloids and phytosterols were isolated from the EtOH extract of fermented mycelia Xylaria nigripes , a precious medicinal fungus known as Wuling Shen in Chinese. On basis spectroscopic methods, structures new naturally occurring determined to be (4 S )‐3,4‐dihydro‐4‐(4‐hydroxybenzyl)‐3‐oxo‐1 H ‐pyrrolo[2,1‐ c ][1,4]oxazine‐6‐carbaldehyde ( 1 ), methyl (2 )‐2‐[2‐formyl‐5‐(hydroxymethyl)‐1...