A5101904026- Sulfur Compounds in Biology
- Spatial Neglect and Hemispheric Dysfunction
- Osteoarthritis Treatment and Mechanisms
- Transcranial Magnetic Stimulation Studies
- Kawasaki Disease and Coronary Complications
- Lung Cancer Treatments and Mutations
- Ion Transport and Channel Regulation
- Alcohol Consumption and Health Effects
- Mast cells and histamine
- Cancer-related Molecular Pathways
- Hip and Femur Fractures
- Peptidase Inhibition and Analysis
- Bone and Dental Protein Studies
- Neuroscience and Neuropharmacology Research
- Cancer Research and Treatments
- Pharmacogenetics and Drug Metabolism
- Sarcoma Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- RNA modifications and cancer
- Coronary Artery Anomalies
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Bone fractures and treatments
- Liver Disease Diagnosis and Treatment
- Glioma Diagnosis and Treatment
Shanghai Jiao Tong University
2011-2024
Shanghai First People's Hospital
2012-2024
Nanjing Medical University
1990-2024
Shandong Sport University
2024
Capital Medical University
2016-2024
Nanjing Drum Tower Hospital
2024
Jiangxi University of Science and Technology
2022-2023
National University of Singapore
2017-2022
Tiangong University
2019-2022
Soochow University
2011-2022
Diabetic kidney disease is known as a major cause of chronic and end stage renal disease. Polysulfides, class chemical agents with chain sulfur atoms, are found to confer protective effects in acute injury. However, whether polysulfide donor, sodium tetrasulfide (Na2S4), confers against diabetic nephropathy remains unclear. Our results showed that Na2S4 treatment ameliorated dysfunctional histological damage kidneys through inhibiting the overproduction inflammation cytokine reactive oxygen...
Abstract Tumor angiogenesis is a hallmark of cancer and involved in the tumorigenesis solid tumors. B7-H3, an immune checkpoint molecule, plays critical roles proliferation, metastasis diverse tumors; however, little known about biological functions molecular mechanism underlying B7-H3 regulating colorectal (CRC) angiogenesis. In this study, we first demonstrated that expression was significantly upregulated positively associated with platelet endothelial cell adhesion molecule-1 (CD31)...
Mutations in the epidermal growth factor receptor (EGFR) are commonly occurring glioblastoma. Enhanced activation of EGFR can occur through a variety different mechanisms, both ligand-dependent and ligand-independent. Numerous evidence has suggested that is overexpressed most primary glioblastomas some secondary characteristic more aggressive glioblastoma phenotypes. Additionally, recent studies have revealed wild-type EGFR, to greater extent hyper-activating mutants induced substantial...
// Lei Cao 1, 2, 5, * , Xiaoyu Fan Wei Jing 3 Yingchao Liang 2 Rui Chen Yingying Liu Minhui Zhu Rongjie Jia Hao Wang Xueguang Zhang 5 Yanyun 1 Xuyu Zhou Jian Zhao 4, 6 Yajun Guo School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, People's Republic China International Joint Cancer Institute, The Second Military Medical 200433, Changhai Hospital, 4 PLA General Hospital Center, Postgraduate Beijing, 100853, Clinical Immunology Laboratory, First Affiliated Suzhou Suzhou, 215007,...
Cisplatin is a major chemotherapeutic drug for solid tumors whereas it may lead to severe nephrotoxicity. Despite decades of efforts, effective therapies remain largely lacking this disease. In the current research, we investigated therapeutic effect hydrogen polysulfide, novel sulfide (H2S) derived signaling molecule, in cisplatin nephrotoxicity and mechanisms involved. Our results showed that polysulfide donor Na2S4 ameliorated cisplatin-caused renal toxicity vitro vivo through suppressing...
Developing high-performance non-noble metal bifunctional oxygen reduction and evolution reaction electrocatalysts is a critical factor for the commercialization of rechargeable Zn-air batteries. Herein, Co/Co-N/Co-O rooted on reduced graphene oxide (rGO) hybrid boron nitrogen codoped carbon (BCN) nanotube arrays (BCN/rGO-Co) prepared by facile low-temperature precross-linking high-temperature pyrolysis treatment. Benefit from synergistic effect its B/N codoping, active sites, 3D porous...
Abstract Osteochondral defects affect both the articular cartilage and underlying subchondral bone, but poor osteochondral regeneration is still a daunting challenge. Although tissue engineering technology provides promising approach for repair, an ideal biphasic scaffold in high demand with regards to proper biomechanical strength. In this study, oriented poly( l ‐lacticacid)‐ co ‐poly( ε ‐caprolactone) P(LLA‐CL)/collagen type I(Col‐I) nanofiber yarn mesh, fabricated by dynamic liquid...
Abstract Objectives Excessive exposure to acetaminophen (APAP, paracetamol) can cause liver injury through formation of a reactive metabolite that depletes hepatic glutathione and causes hepatocellular oxidative stress damage. Generation this is mediated by Cytochrome-P450 (CYP) isoforms, mainly CYP2E1. A number naturally occurring flavonoids mitigate APAP-induced hepatotoxicity in experimental animal models. Our objective was determine the mechanism these protective effects evaluate...
Background: Kawasaki disease (KD) is a self-limiting illness with acute systematic vascular inflammation. It causes pathological changes in mostly medium and small-sized arteries, especially the arteria coronaria, which adds risk of developing coronary heart adults. Materials methods: We detected miR-223-3p expression 30 KD patients combined 12 normal controls using miRNA microarrays RT-PCR. A mouse model was constructed Candida albicans water insoluble substance (CAWS). also checked...
Nitroxyl (HNO), one-electron reduced and protonated sibling of nitric oxide (NO), is a potential regulator cardiovascular functions. It produces positive inotropic, lusitropic, myocardial anti-hypertrophic vasodilator properties. Despite these favorable actions, the significance possible mechanisms HNO in diabetic hearts have yet to be fully elucidated. H9c2 cells or primary neonatal mouse cardiomyocytes were incubated with normal glucose (NG) high (HG). Male C57BL/6 mice received...