A5005565106- Pulmonary Hypertension Research and Treatments
- Sulfur Compounds in Biology
- Eicosanoids and Hypertension Pharmacology
- Ovarian function and disorders
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Circular RNAs in diseases
- Nitric Oxide and Endothelin Effects
- MicroRNA in disease regulation
- Alcohol Consumption and Health Effects
- Advanced Surface Polishing Techniques
- RNA modifications and cancer
- Adhesion, Friction, and Surface Interactions
- Medicinal Plant Pharmacodynamics Research
- Retinal Diseases and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Advanced machining processes and optimization
- Respiratory and Cough-Related Research
- Autophagy in Disease and Therapy
- Asthma and respiratory diseases
- Virus-based gene therapy research
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
Nanchang University
2025
Harbin Medical University
2010-2024
Institute of Tibetan Plateau Research
2022-2024
Tibet University
2023-2024
Jinan University
2023-2024
Sun Yat-sen University Cancer Center
2024
Jiangsu Province Hospital
2021-2024
Southern University of Science and Technology
2020-2024
Nanjing University of Chinese Medicine
2020-2024
Sun Yat-sen University
2024
Section:ChooseTop of pageAbstract <<Study DesignMethodsResultsDiscussionReferencesCITING ARTICLES
This study was designed to investigate the protective effect of curcumin against d-galactose (d-gal)-induced premature ovarian failure (POF) in mice. A mouse POF model induced by subcutaneous injection d-gal (200 mg/kg/day) daily for 42 days. Mice group received both treatment and intraperitoneal (100 Ovarian function, oxidative stress apoptosis were evaluated. The P, E2 SOD levels higher, FSH, LH MDA significantly lower than those group. proportion primordial follicles also higher that In...
Increasing evidence has demonstrated a significant role of long non-coding RNAs (lncRNAs) in diverse biological processes, and many which are likely to have functional roles vascular remodeling. However, their functions pulmonary arterial hypertension (PAH) remain largely unknown. Pulmonary remodeling is an important pathological feature PAH, leading increased resistance reduced compliance. artery smooth muscle cells (PASMCs) dysfunction involved Long noncoding potential regulators PASMCs...
Abstract Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder characterized by chronic low-grade inflammation. Previous studies have demonstrated that the gut microbiome can affect host tissue cells’ mRNA N6-methyladenosine (m6A) modifications. This study aimed to understand role of intestinal flora in ovarian cells inflammation regulating m6A modification particularly inflammatory state PCOS. The composition PCOS Control groups was analyzed 16S rRNA sequencing, short...
BACKGROUND: Pulmonary hypertension, characterized by vascular remodeling, currently lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells plays a pivotal role in the initiation and progression hypertension (PH). ErbB3 (human epidermal growth factor receptor 3), also recognized as HER3, is member ErbB family tyrosine kinases. METHODS: Microarray, immunofluorescence, Western blotting analyses were conducted to investigate pathological ErbB3. Blood samples...
Cisplatin is a major chemotherapeutic drug for solid tumors whereas it may lead to severe nephrotoxicity. Despite decades of efforts, effective therapies remain largely lacking this disease. In the current research, we investigated therapeutic effect hydrogen polysulfide, novel sulfide (H2S) derived signaling molecule, in cisplatin nephrotoxicity and mechanisms involved. Our results showed that polysulfide donor Na2S4 ameliorated cisplatin-caused renal toxicity vitro vivo through suppressing...
Abstract Efficient isolation of embryonic stem (ES) cells from pre-implantation porcine embryos has remained a challenge. Here, we describe the derivation stem-like (pESLCs) by seeding isolated inner cell mass (ICM) in vitro -produced blastocyst into α-MEM with basic fibroblast growth factor (bFGF). The pESL kept normal karyotype and displayed flatten clones, similar phenotype to human (hES cells) rodent epiblast cells. These exhibited alkaline phosphatase (AP) activity expressed...
POSTN (Periostin) is an ECM (extracellular matrix) protein involved in tissue remodeling response to injury and a contributing factor tumorigenesis, suggesting that plays role the pathogenesis of pulmonary hypertension (PH).We aimed gain insight into mechanistic contribution experimental mouse models PH correlate these findings with humans.We used genetic epistasis approaches human artery endothelial cells (hPAECs), smooth muscle cells, (Sugen 5416/hypoxia or chronic hypoxia) discern its...
Abstract Background Polycystic ovary syndrome (PCOS) is an endocrinological and metabolic disorder that can lead to female infertility. Lipid metabolomics proteomics are the new disciplines in systems biology aimed discover pathway changes diseases diagnosis of biomarkers. This study aims reveal features PCOS explore its pathogenesis at protein level. Methods We collected follicular fluid samples granulosa cells women with normal who underwent vitro fertilization(IVF) embryo transfer were...
Hypoxia and oxidative stress contribute to the development of pulmonary hypertension (PH). tRNA-derived fragments play important roles in RNA interference cell proliferation, but their epitranscriptional PH have not been investigated. We aimed gain insight into mechanistic contribution stress-induced 8-oxoguanine vascular remodeling.
Pulmonary artery endothelial plexiform lesion is responsible for pulmonary vascular remodeling (PVR), a basic pathological change of arterial hypertension (PAH). Recent evidence suggests that epoxyeicosatrienoic acid (EET), which derived from arachidonic by cytochrome p450 (CYP) epoxygenase, has an essential role in PAH. However, until now, most research focused on vasoconstriction; it unclear whether EET produces mitogenic and angiogenic effects cells (PAEC). Here we found 500 nM/l 8,9-EET,...
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus. Abnormal energy metabolism in endothelium involved the progression diabetic retinopathy. Bile Acid G-Protein-Coupled Membrane Receptor (TGR5) has emerged as novel regulator metabolic disorders. However, role TGR5 mellitus-induced dysfunction retinas largely unknown. Herein, enzyme-linked immunosorbent assay was used for analyzing bile acid (BA) profiles rat and retinal endothelial cells (RMECs) cultured...
Background/Aims: This study investigated the effect of consecutive superovulation on ovaries and established a premature ovarian failure (POF) model in mice. Methods: The mouse POF was induced by 5-15 treatments with pregnant mare serum gonadotropin (PMSG), human chorionic (HCG) prostaglandin F2α (PGF2α). Normal adult mice were compared displaying natural aging. following biochemical parameters measured: including follicle-stimulating hormone (FSH), luteinizing (LH), progesterone (P),...