A5082736214- Ovarian function and disorders
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Medicinal Plant Pharmacodynamics Research
- Phytoestrogen effects and research
- Sperm and Testicular Function
- Blood Coagulation and Thrombosis Mechanisms
- RNA modifications and cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Antioxidant Activity and Oxidative Stress
- Extracellular vesicles in disease
- Growth Hormone and Insulin-like Growth Factors
- Toxin Mechanisms and Immunotoxins
- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Studies
- Lipid metabolism and disorders
- Ginseng Biological Effects and Applications
- Heparin-Induced Thrombocytopenia and Thrombosis
- Prenatal Screening and Diagnostics
- Garlic and Onion Studies
- Cardiovascular Disease and Adiposity
Nanjing University of Chinese Medicine
2012-2024
Jiangsu Province Hospital
2023-2024
Institute of Reproductive Medicine
2018
Nanjing University
2013
Renji Hospital
2011
Abstract Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder characterized by chronic low-grade inflammation. Previous studies have demonstrated that the gut microbiome can affect host tissue cells’ mRNA N6-methyladenosine (m6A) modifications. This study aimed to understand role of intestinal flora in ovarian cells inflammation regulating m6A modification particularly inflammatory state PCOS. The composition PCOS Control groups was analyzed 16S rRNA sequencing, short...
The aim of this study was to investigate the effect chromosomal polymorphic variations on outcome IVF and embryo transfer (IVF–embryo transfer) treatment for infertile couples. During period from October 2006 December 2009, 1978 couples who had received their first IVF–embryo cycle in our hospital were selected retrospective study, frequency calculated. From these, 1671 divided into three groups: 1402 with normal chromosomes (Group 1/control group), 82 only females 2) 187 males 3). clinical...
BACKGROUND:Worldwide, polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder that affects women of reproductive age. Naringenin natural flavanone, derived from grapefruit. The aims this study were to investigate the effects naringenin on antioxidant steroidogenic enzyme activity in rat model letrozole-induced PCOS. MATERIAL AND METHODS:The induction PCOS was undertaken by giving 28 female Sprague-Dawley rats dose letrozole (1 mg/kg) daily for 21 days. There four...
Abstract Background Polycystic ovary syndrome (PCOS) is an endocrinological and metabolic disorder that can lead to female infertility. Lipid metabolomics proteomics are the new disciplines in systems biology aimed discover pathway changes diseases diagnosis of biomarkers. This study aims reveal features PCOS explore its pathogenesis at protein level. Methods We collected follicular fluid samples granulosa cells women with normal who underwent vitro fertilization(IVF) embryo transfer were...
Purpose: To investigate the effect of quercetin, a natural flavonoid, on biochemical parameters in letrozole-induced polycystic ovary syndrome (PCOS) ratsMethods: Oral glucose test was performed with aid glucometer. Estradiol, testosterone and steroidogenic enzyme activities were determined using standard protocols. Superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPX) by methods. Histological analysis carried out haematoxylin eosin (H&E) staining.Results: Quercetin...
Background: Reproductive endocrine disorder can impair endometrial receptivity, preventing embryo implantation and increasing miscarriage risk. Impaired receptivity contributes significantly to female infertility. Inflammatory signaling pathways including the IL-6/STAT3 pathway help embryos implant. Therefore, it is crucial explore relationship between receptivity. Objective: To investigate mechanism by which Bushen Zhuyun decoction (BSZY) enhances in rats through pathway. Methods:...
The authors requested retraction after reviewing the manuscript and determining that there were errors in data. Reference: Yanli Hong, Yanyun Yin, Yong Tan, Ke Huifang Zhou. Flavanone, Naringenin, Modifies Antioxidant Steroidogenic Enzyme Activity a Rat Model of Letrozole-Induced Polycystic Ovary Syndrome. Med Sci Monit, 2019; 25: 395-401. DOI: 10.12659/MSM.912341.
Anti-coagulant unfractionated heparin of low molecular weight (ACUHlmw) therapy is popularly practised in the recurrent miscarriages (RMC) due to its anti-coagulant properties. However, several vitro investigations have hypothesized about possible immunological effects ACUHlmw.We examined pregnant women with cryptic RMC (cRMC) determine whether ACUHlmw could regulate immune reaction vivo during their pregnancy. In this study, a total 51 were subjected tinzaparin and 48 patients considered as...
To explore the pharmacological mechanism of Bushen Huatan (BSHT) recipe in treatment polycystic ovary syndrome (PCOS).The active ingredients component drugs were screened through TCMSP, and their potential targets predicted by PubChem Swiss target prediction. Genecards OMIM used to screen therapeutic PCOS. The drug disease corrected using Uniprot, intersection obtained. protein-protein interaction (PPI) network was constructed STRING, analyzed with CytoNCA core targets. DAVID for GO...
Abstract Background Polycystic ovary syndrome (PCOS) is an endocrinological and metabolic disorder that can lead to female infertility. Lipid metabolomics proteomics are the new disciplines in systems biology aimed discover pathway changes diseases diagnosis of biomarkers. This study aims reveal features PCOS explore its pathogenesis at protein level. Methods We collected follicular fluid samples granulosa cells women with normal who underwent vitro fertilization(IVF) embryo transfer were...
Objectives Although there have been growing concerns about the adverse effects of air pollution on preterm birth, little is known whether pollutants contribute to birth. This study aims evaluate association between prenatal exposure and Methods We obtained birth data in Seoul January 1, 1998 December 31, 2000 from Korean National Birth Register. The last menstrual period ultrasound assessment were used estimate gestational age. Preterm was defined as less than 37 weeks completed gestation....