A5046616265- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Temporomandibular Joint Disorders
- Molecular Sensors and Ion Detection
- Lignin and Wood Chemistry
- Laser Applications in Dentistry and Medicine
- Osteoarthritis Treatment and Mechanisms
- Catalytic Cross-Coupling Reactions
- BRCA gene mutations in cancer
- Synthesis and Catalytic Reactions
- Luminescence and Fluorescent Materials
- Digital Radiography and Breast Imaging
- Advancements in Solid Oxide Fuel Cells
- Organometallic Complex Synthesis and Catalysis
- Crystallography and molecular interactions
- Data Quality and Management
- Sulfur-Based Synthesis Techniques
- Advanced biosensing and bioanalysis techniques
- Carbon dioxide utilization in catalysis
- Infrared Thermography in Medicine
- Cancer therapeutics and mechanisms
- Coordination Chemistry and Organometallics
Shaanxi University of Science and Technology
2023-2025
Fuyang Normal University
2005-2025
Yanbian University Hospital
2025
Tsinghua University
2022-2025
Vanke (China)
2022-2025
Hebei Eye Hospital
2022-2024
Changzhi Medical College
2023-2024
Vividion Therapeutics (United States)
2024
East China University of Science and Technology
2024
Nanjing University of Chinese Medicine
2022-2023
Recent studies have demonstrated the existence of a soluble fibroblast growth factor (FGF) receptor type 1 (FGFR1) extracellular domain in circulation and vascular basement membranes. However, process FGFR1 ectodomain release from plasma membrane is not known. Here we report that 72-kDa gelatinase A (matrix metalloproteinase 2, MMP2) can hydrolyze Val368-Met369 peptide bond ectodomain, eight amino acids upstream transmembrane domain, thus releasing entire domain. Similar results were...
Abstract Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder characterized by chronic low-grade inflammation. Previous studies have demonstrated that the gut microbiome can affect host tissue cells’ mRNA N6-methyladenosine (m6A) modifications. This study aimed to understand role of intestinal flora in ovarian cells inflammation regulating m6A modification particularly inflammatory state PCOS. The composition PCOS Control groups was analyzed 16S rRNA sequencing, short...
Five new alkyl zinc complexes supported by different formylfluorenimide ligands were prepared and characterized.
Alzheimer's disease (AD) is currently one of the most difficult and challenging diseases to treat. Based on ‘multi-target-directed ligands’ (MTDLs) strategy, we designed synthesised a series new compounds against AD by combining pharmacophores resveratrol clioquinol. The results biological activity tests showed that hybrids exhibited excellent MTDL properties: significant ability inhibit self-induced β-amyloid (Aβ) aggregation copper(II)-induced Aβ aggregation, potential antioxidant...
Herein, a novel strategy was proposed for identifying carbon monoxide (CO), which plays crucial part in living systems. For the first time, we have managed to design, synthesize, and characterize successfully this new Cu2+-assisted fluorescent probe (DPHP) detecting CO. Compared with commonly adopted Pd0-mediated Tsuji–Trost reaction recognition method, such did not engage costly palladium (II) salt generated no leaving group, indicating satisfactory anti-interference ability. The mechanism...
The 4-aryl-2-pyridone scaffold is considered to be a privileged pharmacophore. Diversity-oriented synthesis of its derivatives pressing demand within the field medicinal chemistry. Herein, we report site-selective C–H arylation 2-pyridones via palladium/norbornene cooperative catalysis. success this research based on nucleophilicity and metalation properties exhibited by C5 position in 2-pyridones, an activated norbornene that was employed capture C5-palladation intermediate transfer it C4...
AIMS/BACKGROUND: To study the expression of H19 gene in hepatocellular carcinoma. is an imprinted, maternally expressed gene, which tightly linked, both physically and functionally, to paternally insulin-like growth factor 2 (IGF II). IGF II known be involved liver carcinogenesis. was first discovered fetal mouse under same regulatory genes as alpha fetoprotein (alpha FP), a widely used tumour marker for METHODS: Using radioactive non-radioactive situ hybridisation, compared with presence...
A palladium-catalyzed oxidative C–H bond decarboxylative acylation of N-nitrosoanilines using α-oxocarboxylic acid as the acyl source is described. The catalyst Pd(OAc)2 and oxidant (NH4)2S2O8 enabled ortho-acylation at room temperature, affording an array N-nitroso-2-aminobenzophenones in moderate to excellent yields.
Deep learning has improved the state-of-the-art results in many domains, leading to development of several systems for facilitating deep learning. Current systems, however, mainly focus on model building and training phases, while issues lifecycle management are largely ignored. modeling contains a rich set artifacts frequently conducted tasks, dealing with them is cumbersome left users. To address these comprehensive manner, we demonstrate ModelHub, which includes novel versioning system...
Abstract Objective To study the changes of retinal function in type 2 diabetes mellitus(DM) patients without apparently diabetic retinopathy via multifocal electroretinogram. Methods: Thirty-six DM (72 eyes) visible were selected as experimental group, and thirty-five healthy subjects (70 control group. All underwent electroretinogram (mf- ERG). Results Compared with implicit time delay P1 wave first ring, third fourth fifth ring group was significant (t = -3.154, p 0.004, t -8.21, 0.000,...
China's growth over recent decades rapidly transformed the urban landscapes. Green spaces provide numerous health benefits including acting as nature-based solutions for climate change risks. Our study aims to track greenness trends in areas China and quantify impact of on adult mortality. In China, we mapped human population distribution aged 20 above with a 1 km grid (30 arc-second) used satellite-based remote sensing measure green space time create population-weighted normalized...
ABSTRACT A series of rare‐earth metal alkyl complexes containing chiral cyclohexyl‐bridged bis( β ‐diketiminate) ligands have been synthesized, with a general chemical formula {Cy[NC (Me)CHC (Me)NAr] 2 }RECH SiMe 3 [Cy=(1R, 2R)‐(‐)‐1,2‐cyclohexyl, Ar=2,6‐ i Pr C 6 H , RE=Dy( 1 ), Er( Yb( Y( 4 )]. These compounds were prepared in good yields by the reaction RE[CH ] (THF) Cy[NHC ( L ). Comprehensive characterizations all achieved through spectroscopic methods and elemental analysis. The...
Heparan sulfate (HS) proteoglycans play a key role in cell proliferation induced by basic fibroblast growth factor (FGF-2) and other heparin-binding factors. To modulate the involvement of HS, we have used synthetic, nonsulfated polyanionic aromatic compound (RG-13577) that mimics functional features heparin/HS. FGF-2-stimulated vascular endothelial cells was markedly inhibited presence 5-10 microg/ml RG-13577 (poly-4-hydroxyphenoxy acetic acid; Mr approximately 5 kD). Direct interaction...