A5101691100- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Hearing, Cochlea, Tinnitus, Genetics
- Machine Learning in Healthcare
- Industrial Technology and Control Systems
- Genetic Associations and Epidemiology
- Neuroscience of respiration and sleep
- Artificial Intelligence in Healthcare
- Urban Green Space and Health
- Urban Transport and Accessibility
- Per- and polyfluoroalkyl substances research
- Hearing Loss and Rehabilitation
- Topic Modeling
- Epigenetics and DNA Methylation
- Gear and Bearing Dynamics Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Iterative Learning Control Systems
- Dialysis and Renal Disease Management
- Mindfulness and Compassion Interventions
- Hand Gesture Recognition Systems
- Blind Source Separation Techniques
- Fibroblast Growth Factor Research
- Bariatric Surgery and Outcomes
- Culinary Culture and Tourism
Tsinghua University
2025
Vanke (China)
2025
Guangzhou Medical University
2024
Shanghai Jiao Tong University
2013-2024
XinHua Hospital
2018-2024
North China Electric Power University
2024
Brown University
2024
Tongren Hospital
2016-2019
Shanghai Children's Medical Center
2012-2013
China Coal Research Institute (China)
2006
Humans are widely exposed to environmental perfluoroalkyl substances (PFAS), which may affect glucose homeostasis. However, research linking PFAS exposure homeostasis during pregnancy is limited and the results were inconsistent. We aimed investigate association between in a large prospective cohort. A total of 2747 pregnant women who participated Shanghai Birth Cohort, had blood samples early completed 75 g oral tolerance test (OGTT) at 24–28 gestational weeks included. 10 determined by...
Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes. Screening for GDM and applying adequate interventions may reduce the risk of However, diagnosis depends largely on tests performed in late second trimester. The aim present study was to bulid a simple model predict early pregnancy Chinese women using biochemical markers machine learning algorithm. Data total 4771 pregnant gestation were used fit risk-prediction model. Predictive maternal factors selected...
Gestational diabetes mellitus (GDM) “program” an elevated risk of metabolic syndrome in the offspring. Epigenetic alterations are a suspected mechanism. GDM has been associated with placental DNA methylation changes some epigenome-wide association studies. It remains unclear which genes or pathways affected, and whether any differential gene methylations correlated to fetal growth circulating health biomarkers. In study using Infinium MethylationEPIC Beadchip, we sought identify genome-wide...
China's growth over recent decades rapidly transformed the urban landscapes. Green spaces provide numerous health benefits including acting as nature-based solutions for climate change risks. Our study aims to track greenness trends in areas China and quantify impact of on adult mortality. In China, we mapped human population distribution aged 20 above with a 1 km grid (30 arc-second) used satellite-based remote sensing measure green space time create population-weighted normalized...
Using time-dependent Cox regression models, we examined associations of common antihypertensive medications with overall cancer survival (OS) and disease-specific (DSS), comprehensive adjustment for potential confounding factors. Participants were from the Shanghai Women's Health Study (1996-2000) Men's (2002-2006) in Shanghai, China. Included 2,891 incident breast, colorectal, lung, stomach cases. Medication use was extracted electronic medical records. With a median 3.4-year follow-up...
Walking and running activities (W&RAs), encompassing strolling, slow walking, brisk jogging, running, hold significant importance as popular forms of exercise within urban parks. Recognized for their efficacy in promoting public health preventing chronic diseases, understanding the nuanced impact pathway features on W&RAs is crucial advancing health-centric park planning. Based extensive, high-frequency field observation data, we utilize multiple OLS regression models univariate to...
Postnatal permanent childhood hearing impairment (PCHI) is frequent (0.25%–0.99%) and difficult to detect in the early stage, which may impede speech, language cognitive development of affected children. Genetic tests common variants associated with postnatal PCHI newborns provide an efficient way identify those at risk. In this study, we detected a strong association p.V37I exclusive genotype GJB2 Chinese Hans (P = 1.4×10−10; OR 62.92, 95% CI 21.27–186.12). This Eastern Asians was present...
Abstract Recessive mutations in SLC26A4 and rarer cases double heterozygous of FOXI1/SLC26A4 KCNJ10/SLC26A4 lead to hearing impairment associated with enlarged vestibular aqueduct (EVA), the most common inner ear malformation. In our large cohort study, we addressed several important questions molecular etiology this disorder. The overall prevalence nonsyndromic childhood sensorineural loss (11.2%, 37/330) were determined by sequencing 330 impaired children who did not undergo radiologic...
Abstract Objective To discover diverse genotype-phenotype associations affiliated with Type 2 Diabetes Mellitus (T2DM) via genome-wide association study (GWAS) and phenome-wide (PheWAS), more cases (T2DM subjects) controls (subjects without T2DM) are required to be identified (e.g., Electronic Health Records (EHR)). However, existing expert based identification algorithms often suffer in a low recall rate could miss large number of valuable samples under conservative filtering standards. The...
Imaging examinations, such as ultrasonography, magnetic resonance imaging and computed tomography scans, play key roles in healthcare settings. To assess improve the quality of diagnosis, we need to manually find compare pre-existing reports pathology examinations which contain overlapping exam body sites from electrical medical records (EMRs). The process retrieving those is time-consuming. In this paper, propose a convolutional neural network (CNN) based method can better utilize semantic...
Objective: Early life is a critical period for gut microbial development. It still controversial whether there microbiota during healthy pregnancy. Gestational diabetes mellitus (GDM) associated with increased risk of metabolic syndrome in the offspring and mechanisms are unclear. We sought to explore placenta cord blood may be altered GDM. Methods: Placenta samples were collected from 8 GDM 7 euglycemic (control) term pregnancies caesarean deliveries without evidence clinical infections....
Ancient canal towns in Jiangnan have become important tourist destinations due to their unique water town scenery and historical value. Creating a image boosts these ancient towns’ competitive edge tourism contributes significantly preservation growth. The vast amount of data from social media has an essential source for uncovering perceptions. This study takes two Shanghai, Zhaojialou Fengjing, as case areas. In order explore compare the destination images towns, perception tourists...
Abstract Background Fetal overgrowth “programs” an elevated risk of type 2 diabetes in adulthood. Epigenetic alterations may be a mechanism programming the vulnerability. We sought to characterize genome-wide placental gene methylations fetal and associations with metabolic health biomarkers including leptin, adiponectin growth factors. Results Comparing DNA large-for-gestational-age (LGA, indicator overgrowth, n = 30) versus optimal-for-gestational-age (OGA, control, infants using Illumina...
Urban parks play a pivotal role in shaping physical activity (PA), yet our comprehension of the specific influence park greenery remains limited. In this study, we focused on three Shanghai urban parks, conducting comprehensive year-long on-site observation to delve into greenery’s impact PA. By employing hierarchical linear model analysis, uncovered robust correlation between internal and surrounding PA density diversity. Within 400 m radius, indicators such as normalized difference...
Physical inactivity poses a significant public health challenge. Numerous studies have argued that urban parks can promote physical activity (PA). However, evidence of observed over long periods time in is still very lacking. Our serial cross-sectional study within Shanghai investigated seasonal and daily variations PA. Employing geographically temporally weighted regression (GTWR) model, we established spatiotemporal relationships between park characteristics PA levels. We found (1) Highest...
It remains unclear which early gestational biomarkers can be used in predicting later development of diabetes mellitus (GDM). We sought to identify the optimal combination GDM machine learning (ML) models.
Fibroblast growth factor 19 (FGF19) has been implicated in glucose homeostasis. Gestational diabetes mellitus (GDM) enhances fetal insulin secretion and growth. Girls weigh less are more resistant than boys at birth. We sought to assess whether FGF19 is associated with GDM explore potential sex dimorphic associations. This was a nested case-control study the Shanghai Birth Cohort, including 153 pairs of newborns versus euglycemic mothers matched by infant’s gestational age Cord plasma FGF19,...
Gestational diabetes mellitus (GDM) is a common pregnancy complication. Its etiology remains incompletely understood. Studies in recent years suggest that fetal sex may affect maternal metabolic milieu during pregnancy. We sought to assess whether there dimorphism the risk factors of GDM. In prospective cohort Shanghai, China, we studied 2435 singleton pregnant women without pre-existing diabetes. GDM was diagnosed according International Association Diabetes and Pregnancy Study Groups...
Fetuin-A is a multifunctional glycoprotein that has been implicated in insulin resistance and bone metabolism. We assessed whether fetuin-A associated with poor or excessive fetal growth. In the Shanghai Birth Cohort, we conducted nested case-control study of 60 trios small-for-gestational-age (SGA, birth weight <10th percentile), optimal-for-gestational-age (OGA, 25-75th, reference) large-for-gestational-age (LGA, >90th percentile) infants matched by sex gestational age. Cord plasma...
Objective: To investigate the prevalence and risk factors for chronic kidney disease (CKD) among community elderly population in Shanghai, China, order to provide early diagnosis treatment of CKD, improve quality life people.Methods: In all, 24,886 residents (≥65 years old) were selected from Changning District China 2014. They interviewed tested reduced renal function estimated GFR by CKD-EPI equation. The associations demographic characteristics, healthy characteristics (e.g.,...
The ability of a preventive nutritional intervention to reduce the morbidity gestational diabetes mellitus (GDM) remains controversial. We aim assess whether GDM can be prevented by an individualised in pregnant women who are at high risk for disease based on prediction model.