A5100731687- Ion channel regulation and function
- MicroRNA in disease regulation
- RNA modifications and cancer
- Ion Transport and Channel Regulation
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Nicotinic Acetylcholine Receptors Study
- Glioma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Venomous Animal Envenomation and Studies
- Radiomics and Machine Learning in Medical Imaging
- Asthma and respiratory diseases
- Venous Thromboembolism Diagnosis and Management
- RNA Research and Splicing
- Renal and related cancers
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Mesenchymal stem cell research
- Cardiac electrophysiology and arrhythmias
- RNA regulation and disease
- Cardiac tumors and thrombi
- Immune Cell Function and Interaction
Capital Medical University
2022-2025
Beijing Tian Tan Hospital
2022-2025
Shanghai Normal University
2025
Chinese Institute for Brain Research
2024-2025
China Pharmaceutical University
2024
Shenyang Pharmaceutical University
2015-2024
Peking University Cancer Hospital
2010-2024
Weifang Medical University
2024
University of Nottingham Ningbo China
2024
First Hospital of China Medical University
2016-2024
Epidemiologic studies on mild cognitive impairment (MCI) are limited in China.Using a multistage cluster sampling design, total of 10,276 community residents (6096 urban, 4180 rural) aged 65 years or older were evaluated and diagnosed with normal cognition, MCI, dementia. MCI was further categorized by imaging into caused prodromal Alzheimer's disease (MCI-A), resulting from cerebrovascular (MCI-CVD), vascular risk factors (MCI-VRF), other diseases (MCI-O).The prevalences overall MCI-A,...
To examine the association between serum matrix metalloproteinases-9 (MMP-9) levels and prognosis of acute ischemic stroke.We measured MMP-9 in 3,186 participants (2,008 men 1,178 women) from China Antihypertensive Trial Acute Ischemic Stroke (CATIS). Study outcome data on death, major disability (modified Rankin Scale score ≥3), vascular disease were collected at 3 months after stroke onset.During follow-up, 767 (24.6%) experienced or died. Serum was significantly associated with an...
Abstract Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and contributions of coding variants not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting 42,760 individuals. We discover 16 SNPs within 15 new genes/loci psoriasis, including C1orf141 , ZNF683 TMC6 AIM2 IL1RL1 CASR SON ZFYVE16 MTHFR CCDC129 ZNF143 AP5B1 SYNE2...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple immune cells. To elucidate SLE pathogenesis, it essential to understand the dysregulated gene expression pattern linked various clinical statuses with high cellular resolution. Here, we conducted large-scale transcriptome study 6,386 RNA sequencing data covering 27 cell types from 136 and 89 healthy donors. We profiled two distinct cell-type-specific transcriptomic signatures: disease-state disease-activity...
Abstract Neuroinflammation is closely related with the pathogenesis and progress of neurodegenerative diseases including Alzheimer's disease (AD). Loganin, an iridoid glycoside obtained from traditional Chinese medicine Cornus officinalis , has properties inhibiting inflammation improving memory. The present study was aimed to investigate effects loganin on Aβ‐induced explore underlying mechanisms. BV‐2 microglia cells were stimulated 10 µM Aβ 1‐42 for 24 h induce inflammatory damage....
The amiloride-sensitive sodium channel is responsible for the rate-limiting step of reabsorption in distal renal tubule, and thus may play a key role maintenance balance blood pressure. In this study, genetic variant that results change threonine to methionine at amino acid 594 (T594 M) carboxy-terminus beta-subunit has been identified. This was present 6.1% African-American subjects (N = 231) but not seen Caucasians 192). Whole cell voltage clamp B-lymphocytes from individuals with T594 M...
Background/Aims: Lung cancer is one of the most common malignancies in world. Apoptosis-stimulating protein p53 (ASPP2), a tumorigenesis related protein, plays critical role initiation and development various types cancers. However, effect ASPP2 on lung remains unknown. The purpose this study aims to investigate mechanism regulated by miR-21 vitro vivo. Methods: In study, migration invasion assays, apoptosis assay, caspase activity TUNEL staining, real time PCR western blot were used...
A scorpion peptide reported to exhibit both analgesic and antitumor activity in animal models may present as an alternative therapeutic agent for breast cancer. We aimed investigate the effect of Buthus martensii Karsch antitumor-analgesic (BmK AGAP) on cancer cell stemness epithelial-mesenchymal transition (EMT). treated MCF-7 MDA-MB-231 cells with different concentrations rBmK AGAP observed that inhibited stemness, (EMT), migration, invasion. Analysis by qPCR, ELISA, western blot,...
Prolyl-4-hydroxylase subunit 2 (P4HA2) is a member of collagen modification enzymes involved in the remodeling extracellular matrix (ECM). Mounting evidence has suggested that deregulation P4HA2 common cancer. However, role glioma remains unknown. The present study aimed to elucidate expression pattern, oncogenic functions, and molecular mechanisms glioblastoma cells. TCGA datasets paraffin samples were used for examining expressions P4HA2. P4HA2-specific lentivirus was generated assess its...
This study evaluated associations of telomere length with various anthropometric indices general and abdominal obesity, as well weight change.The included 2,912 Chinese women aged 40-70 years. Monochrome multiplex quantitative polymerase chain reaction was applied to measure relative length.Telomere inversely associated body mass index (BMI), waist circumference, waist-to-height ratio, weight, hip circumference (Ptrend = 0.005, 0.004, 0.010, 0.026, respectively), but not waist-to-hip ratio...
Using time-dependent Cox regression models, we examined associations of common antihypertensive medications with overall cancer survival (OS) and disease-specific (DSS), comprehensive adjustment for potential confounding factors. Participants were from the Shanghai Women's Health Study (1996-2000) Men's (2002-2006) in Shanghai, China. Included 2,891 incident breast, colorectal, lung, stomach cases. Medication use was extracted electronic medical records. With a median 3.4-year follow-up...
The R2R3-MYB family of transcription factors (TFs) plays a crucial role in cell specification and secondary metabolism regulation during plant development. In Arabidopsis, MS188, typical protein, is essential for tapetal development pollen wall formation. However, the nuclear localization sequence (NLS) responsible directing MS188 into nucleus has not been fully elucidated. this study, subcellular NLS-containing proteins was determined by GFP tagging tobacco leaves, three NLS regions within...
OBJECTIVE The aim of this study was to evaluate the cortical nonenhancing tumor infiltration (CONTIN) sign as a predictive imaging biomarker for IDH-mutant gliomas, including diffuse gliomas with and without contrast enhancement. METHODS Imaging data were collected from patients (grades 2–4) at Beijing Tiantan Hospital (BTH) January 2019 December 2021 (training set, n = 526) University California, San Francisco, preoperative glioma MRI dataset (UCSF PDGM; validation 501). Two independent...
Against the backdrop of accelerating internationalization in global higher education, STEM universities China's underdeveloped western regions face multifaceted constraints their international development, including resource limitations, geographical disadvantages, and disciplinary structural challenges. Grounded composite ecosystem theory Altbach's (2016) center-periphery model, this study constructs an evaluation index system encompassing four dimensions: human resources, academic output,...