A5047510477- Neuroblastoma Research and Treatments
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- RNA Research and Splicing
- Melanoma and MAPK Pathways
- Chromatin Remodeling and Cancer
- interferon and immune responses
- Zoonotic diseases and public health
- Cancer, Hypoxia, and Metabolism
- Viral Infections and Vectors
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- Plant nutrient uptake and metabolism
- Heat shock proteins research
- RNA regulation and disease
- RNA Interference and Gene Delivery
- Plant Water Relations and Carbon Dynamics
- Cancer, Stress, Anesthesia, and Immune Response
- Virus-based gene therapy research
- Nicotinic Acetylcholine Receptors Study
University of Newcastle Australia
2016-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2023-2025
Shaanxi Provincial People's Hospital
2024
Shanxi Medical University
2024
Henan Provincial People's Hospital
2020-2023
Zhengzhou University
2020-2023
Hunter Medical Research Institute
2022-2023
Shanghai Institutes for Biological Sciences
2016
Shanghai Jiao Tong University
2016
Chinese Academy of Sciences
2016
Abstract The functions of the proto-oncoprotein c-Myc and tumor suppressor p53 in controlling cell survival proliferation are inextricably linked as “Yin Yang” partners normal cells to maintain tissue homeostasis: induces expression ARF (p14 human p19 mouse) that binds inhibits mouse double minute 2 homolog (MDM2) leading activation, whereas suppresses through a combination mechanisms involving transcriptional inactivation microRNA-mediated repression. Nonetheless, regulatory interactions...
Abstract Accumulating evidence suggests significant biological effects caused by extremely low frequency electromagnetic fields (ELF-EMF). Although exo-endocytosis plays crucial physical and roles in neuronal communication, studies on how ELF-EMF regulates this process are scarce. By directly measuring calcium currents membrane capacitance at a large mammalian central nervous synapse, the calyx of Held, we report for first time that critically affects synaptic transmission plasticity....
Abstract Protein products of the regenerating islet-derived ( REG ) gene family are important regulators many cellular processes. Here we functionally characterise a non-protein coding product family, long noncoding RNA (lncRNA) REG1CP that is transcribed from DNA fragment at locus previously thought to be pseudogene. forms an RNA–DNA triplex with homopurine stretch distal promoter REG3A gene, through which helicase FANCJ tethered core where it unwinds double stranded and facilitates...
Genomic amplification of the distal portion chromosome 3q, which encodes a number oncogenic proteins, is one most frequent chromosomal abnormalities in malignancy. Here we functionally characterise non-protein product 3q region, long noncoding RNA (lncRNA) PLANE, upregulated diverse cancer types through copy gain as well E2F1-mediated transcriptional activation. PLANE forms an RNA-RNA duplex with nuclear receptor co-repressor 2 (NCOR2) pre-mRNA at intron 45, binds to heterogeneous...
Distant metastasis is the major cause of clear cell renal carcinoma (ccRCC)-associated mortality. However, molecular mechanisms involved in ccRCC remain to be fully understood. With increasing appreciation role long non-coding RNAs (lncRNAs) cancer development, progression, and treatment resistance, list aberrantly expressed lncRNAs contributing pathogenesis expanding rapidly.Bioinformatics analysis was carried out interrogate publicly available datasets. In situ hybridization qRT-PCR assays...
Climate has critical roles in the origin, pathogenesis and transmission of infectious zoonotic diseases. However, large-scale epidemiologic trend specific response pattern diseases under future climate scenarios are poorly understood. Here, we projected distribution shifts risks main change China. First, shaped global habitat host animals for three representative (2, 6, 12 hosts dengue, hemorrhagic fever, plague, respectively) with 253,049 occurrence records using maximum entropy (Maxent)...
Abstract Active crosstalk between the nervous system and breast cancer cells has been experimentally demonstrated in vitro animal models. However, low frequencies of peripheral nerve presence human cancers reported previous studies (~30% cases) potentially negate a major role development progression. This study aimed to clarify incidence nerves within delineate associations with clinicopathological features. Immunohistochemical staining was conducted formalin‐fixed paraffin‐embedded tissue...
MTH1 helps prevent misincorporation of ROS-damaged dNTPs into genomic DNA; however, there is little understanding how itself regulated. Here, we report that regulated by polyubiquitination mediated the E3 ligase Skp2. In melanoma cells, was upregulated commonly mainly due to its improved stability caused K63-linked polyubiquitination. Although Skp2 along with other components Skp1-Cullin-F-box (SCF) ubiquitin complex physically associated MTH1, blocking SCF function ablated ubiquitination...
The effect of MTH1 inhibition on cancer cell survival has been elusive. Here we report that although silencing does not affect melanoma cells, TH588, one the first-in-class inhibitors, kills cells through apoptosis independently its inhibitory MTH1. Induction by TH588 was alleviated overexpression or introduction bacterial homolog 8-oxodGTPase activity but cannot be inhibited indicating is cause TH588-induced killing cells. Although knockdown did impinge viability it rendered sensitive to...
Abstract P53 inactivation occurs in about 50% of human cancers, where p53‐driven p21 activity is devoid and p27 becomes essential for the establishment G1/S checkpoint upon DNA damage. Here, this work shows that E2F1‐responsive lncRNA LIMp27 selectively represses expression contributes to proliferation, tumorigenicity, treatment resistance p53‐defective colon adenocarcinoma (COAD) cells. competes with mRNA binding cytoplasmically localized hnRNA0, which otherwise stabilizes leading cell...
: Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer into the cell-cycle plays an important role recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms promote cell by facilitating stabilization p27. Purified B16 mouse melanoma expressed higher levels miRNA-27b-3p miRNA-455-3p relative their proliferating counterparts. Induction resulted increased these diverse types human lines. Inhibition or reduced,...
TERT gene rearrangement with transcriptional superenhancers leads to overexpression and neuroblastoma. No targeted therapy is available for clinical trials in patients TERT-rearranged neuroblastoma.Anticancer agents exerting the best synergistic anticancer effects BET bromodomain inhibitors were identified by screening an FDA-approved oncology drug library. The of inhibitor OTX015 proteasome carfilzomib examined immunoblot flow cytometry analysis. efficacy combination was investigated mice...
Rationale: Recurrent and metastatic cancers often undergo a period of dormancy, which is closely associated with cellular quiescence, state whereby cells exit the cell cycle are reversibly arrested in G0 phase.Curative cancer treatment thus requires therapies that either sustain dormant quiescent cells, or preferentially, eliminate them.However, mechanisms responsible for survival remain obscure.Methods: Dual genome-editing was carried out using CRISPR/Cas9-based system to label endogenous...
// Fen Liu 1, 2, * , Chen Jiang Xu Guang Yan 3 Hsin-Yi Tseng Chun Wang Yuan Zhang 2 Hamed Yari Ting La Margaret Farrelly Su Tang Guo Rick F. Thorne 4 Lei Jin Qi 1 and Dong Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China School Medicine Public Health, University Newcastle, NSW, Australia Biomedical Sciences Pharmacy, Environmental Life Sciences, These authors contributed equally to this work Correspondence to: Wang, email: wqdlmu@163.com...
The protooncoprotein N-Myc, which is overexpressed in approximately 25% of neuroblastomas as the consequence MYCN gene amplification, has long been postulated to regulate DNA double-strand break (DSB) repair neuroblastoma cells, but experimental evidence this function presently scant. Here, we show that N-Myc transcriptionally activates noncoding RNA MILIP promote nonhomologous end-joining (NHEJ) through facilitating Ku70–Ku80 heterodimerization cells. High expression was associated with...
Oncogenic mutations of BRAF occur in approximately 10% colon cancers and are associated with their resistance to clinically available therapeutic drugs poor prognosis the patients. Here we report that cancer cells mutant also resistant heat shock protein 90 (HSP90) inhibitor AUY922, this is caused by rebound activation ERK Akt. Although AUY922 triggered rapid reduction Akt both wild-type cells, rebounded shortly latter leading AUY922-induced apoptosis. Reactivation was persistent expression...
Background: As a member of the DExD/H-box RNA helicase family, DHX34 has demonstrated significant correlation with development multiple disorders. Nevertheless, comprehensive investigation between and pan-cancer remains unexplored. Methods: We analyzed value in based on some databases, such as The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Human Protein (HPA) by use R language well online analysis tools, including STRING, TISIDB, TISCH2. And our samples we performed Western...
The deubiquitinase cylindromatosis (CYLD) functions as a tumor suppressor inhibiting cell proliferation in many cancer types including melanoma. Here we present evidence that proportion of melanoma cells are nonetheless addicted to CYLD for survival. expression levels varied widely lines and melanomas vivo, with subset displaying even higher than melanocyte nevi, respectively. Strikingly, although short hairpin RNA (shRNA) knockdown promoted, anticipated, some lines, it reduced viability...
Abstract The use of mitochondrial inhibitors to target oxidative phosphorylation (OXPHOS) in cancer treatment presents a challenge due dose-limiting toxicities. Moreover, while glycolysis-deficient cancers are vulnerable OXPHOS inhibition preclinical models, the full extent phenotypical and mechanistic consequences inhibiting capable glycolysis is not yet well understood. Our results presented here offer promising insights into potential therapeutic gains from combining p53 restoration...
Abstract Background Sporadic parathyroid adenoma (PA) is the most common cause of hyperparathyroidism, yet mechanisms involved in its pathogenesis remain incompletely understood. Methods Surgically removed PA samples, along with normal gland (PG) tissues that were incidentally dissected during total thyroidectomy, analysed using single‐cell RNA‐sequencing 10× Genomics Chromium Droplet platform and Cell Ranger software. Gene set variation analysis was conducted to characterise hallmark...
The relationship between bacteria and tumors has been the hot spot of clinical research in recent years.