A5085975175- Neuroblastoma Research and Treatments
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Software System Performance and Reliability
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Anomaly Detection Techniques and Applications
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- S100 Proteins and Annexins
- Flavonoids in Medical Research
- Cancer, Lipids, and Metabolism
- Treatment of Major Depression
- Molecular Biology Techniques and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Central Venous Catheters and Hemodialysis
- Graphene and Nanomaterials Applications
- Quality and Safety in Healthcare
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Biosimilars and Bioanalytical Methods
University of California, Los Angeles
2025
National University Cancer Institute, Singapore
2024
National University Health System
2024
National Cancer Centre Singapore
2024
Children's Cancer Institute Australia
2014-2023
UNSW Sydney
2014-2023
University of Cambridge
2023
Covalent Associates (United States)
2023
Chinese University of Hong Kong
2023
The University of Texas MD Anderson Cancer Center
2021-2022
The University of California Santa Cruz (UCSC) Genome Browser (http://genome.ucsc.edu) offers online public access to a growing database genomic sequence and annotations for wide variety organisms. is an integrated tool set visualizing, comparing, analysing sharing both publicly available user-generated datasets. As September 2012, basic annotation 'tracks' are provided 63 organisms, including 26 mammals, 13 non-mammal vertebrates, 3 invertebrate deuterostomes, insects, 6 worms, yeast sea...
The University of California Santa Cruz Genome Browser (http://genome.ucsc.edu) offers online public access to a growing database genomic sequence and annotations for wide variety organisms. is an integrated tool set visualizing, comparing, analyzing sharing both publicly available user-generated data sets. In the past year, local has been updated with four new species assemblies, we anticipate another will be released by end 2011. Further, large number annotation tracks have either added,...
Tumor microbiota can produce active metabolites that affect cancer and immune cell signaling, metabolism, proliferation. Here, we explore tumor gut microbiome features chemoradiation response in patients with cervical using a combined approach of deep sequencing, targeted bacterial culture, vitro assays. We identify an obligate L-lactate-producing lactic acid bacterium found tumors, Lactobacillus iners, is associated decreased survival patients, induces chemotherapy radiation resistance...
Background Patients with neuroblastoma due to the amplification of a 130-kb genomic DNA region containing MYCN oncogene have poor prognoses.
MYCN gene amplification in neuroblastoma drives a expression program that correlates strongly with aggressive disease. Mechanistically, trimethylation of histone H3 lysine 4 (H3K4) at target promoters is strict prerequisite for this transcriptional to be enacted. WDR5 H3K4 presenter has been found have an essential role trimethylation. For reason, study, we investigated the relationship between WDR5-mediated and N-Myc programs cells. upregulated Gene analysis revealed genes included those...
Abstract The majority of patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression die the disease. Here our analyses RNA sequencing data identify long noncoding lncNB1 as one transcripts most over-expressed in -amplified, compared -non-amplified, human cells also all other cancers. binds ribosomal protein RPL35 enhance E2F1 synthesis, leading DEPDC1B gene transcription. GTPase-activating induces ERK phosphorylation stabilization....
Abstract Dietary fibers are increasingly appreciated as beneficial nutritional components. However, a requisite role of gut microbiota in fiber function and the overall impact on metabolomic flux remain unclear. We herein showed enhancing effects soluble resistant maltodextrin (RM) glucose homeostasis mouse metabolic disease models. Remarkably, fecal transplantation (FMT) caused pronounced time-dependent improvement tolerance RM recipient mice, indicating causal relationship between...
Abstract Chromosome 17q21-ter is commonly gained in neuroblastoma, but it unclear which gene the region important for tumorigenesis. The JMJD6 at activates transcription. Here we show that forms protein complexes with N-Myc and BRD4, E2F2, c-Myc Knocking down reduces neuroblastoma cell proliferation survival vitro tumor progression mice, high levels of expression human tissues independently predict poor patient prognosis. In addition, associated transcriptional super-enhancers. Combination...
Myc oncoproteins exert tumorigenic effects by regulating expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L the only known histone methyltransferase that catalyzes H3K79 methylation. Here, we show N-Myc upregulates mRNA protein binding to promoter. shRNA-mediated depletion reduced genes ODC1 E2F2 bound Box II domain protein, knockdown neuroblastoma...
The worst subtype of neuroblastoma is caused by MYCN oncogene amplification and N-Myc oncoprotein over-expression. Long noncoding RNAs (lncRNAs) are emerging as critical regulators gene expression tumourigenesis. While Myc oncoproteins well-known to exert tumourigenic effects regulating the protein-coding genes microRNAs, little known about which lncRNAs targets whether target play a role in Myc-induced oncogenesis. Here we performed differential studies using lncRNA microarray cells after...
The separation of rotting garden material from general domestic waste and its collection for processing in industrial composting sites is a relatively new industry the UK. Two cases allergic bronchopulmonary aspergillosis results health surveillance are described team 28 (compost) collectors. A few extrinsic alveolitis due to Aspergillus fumigatus have previously been reported compost workers. In absence any guidance research prevent similar potentially serious illness, we advise that...
Patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein overexpression have very poor prognosis. The cyclin-dependent kinase 7 (CDK7)/super-enhancer inhibitor THZ1 suppresses gene transcription, reduces cell proliferation, but does not cause significant death. protein phosphatase 1 nuclear targeting subunit (PNUTS) has recently been shown interact c-Myc degradation. Here we screened the U.S. Food Drug Administration-Approved Oncology Drugs Set V from...
TERT gene rearrangement with transcriptional superenhancers leads to overexpression and neuroblastoma. No targeted therapy is available for clinical trials in patients TERT-rearranged neuroblastoma.Anticancer agents exerting the best synergistic anticancer effects BET bromodomain inhibitors were identified by screening an FDA-approved oncology drug library. The of inhibitor OTX015 proteasome carfilzomib examined immunoblot flow cytometry analysis. efficacy combination was investigated mice...
Cancer cell repopulation through cycle re‐entry by quiescent (G 0 ) is thought to be an important mechanism behind treatment failure and cancer recurrence. Fa cilitates C hromatin T ranscription (FACT) involved in DNA repair, replication transcription eviction of histones or loosening their contact with DNA. While FACT expression known high a range cancers, the biological significance aberrant increase not clear. We found that prostate lung cells mRNA protein levels were low at G compared...
As a natural flavone, apigenin is abundantly present in vegetables, fruits, oregano, tea, chamomile, wheat sprout and regarded as major component of the Mediterranean diet. Apigenin known to inhibit proliferation different cancer cell lines by inducing G2/M arrest, but it unclear whether this action predominantly imposed on G2 or M phases. In study, we demonstrate that arrests prostate cells at phase flow cytometric analysis co-stained for phospho-Histone H3 DNA. Concurrently, also reduces...
Effective failure prediction and mitigation strategies in high-performance computing systems could provide huge gains resilience of tightly coupled large-scale scientific codes. These would come from prediction-directed process migration resource servicing, intelligent allocation, checkpointing driven by predictors rather than at regular intervals based on nominal mean time to failure. Given probabilistic associations outlier behavior hardware-related metrics with eventual hardware, system...
The ability to predict impending failures (hardware or software) on large scale high performance compute (HPC) platforms, augmented by checkpoint mechanisms could drastically increase the scalability of applications and efficiency platforms. In this paper we present our findings methodologies employed date in search for reliable, advance indicators a 288 node, 4608 core, Opteron based cluster production use at Sandia National Laboratories. support effort have deployed OVIS, Sandia-developed...