A5073776485- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Protease and Inhibitor Mechanisms
- Apelin-related biomedical research
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Blood Coagulation and Thrombosis Mechanisms
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Adipokines, Inflammation, and Metabolic Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Neurological Complications and Syndromes
- Heart rate and cardiovascular health
- Gout, Hyperuricemia, Uric Acid
- Neuropeptides and Animal Physiology
Soochow University
2016-2025
Tulane University
2016-2024
Nanjing University of Posts and Telecommunications
2024
Soochow University
2016-2023
North China University of Science and Technology
2017-2022
Second Affiliated Hospital of Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Affiliated Hospital of Nantong University
2016-2019
Nantong University
2016-2019
Xuzhou Medical College
2017-2019
Abstract Background The triglyceride-glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, two simple surrogate indicators of insulin resistance, have been demonstrated predict cardiovascular disease (CVD). However, very few studies investigated their associations with CVD in European populations. Methods A total 403,335 participants from the UK Biobank data for TyG TG/HDL-C ratio free at baseline were included. Cox models applied evaluate association...
To examine the association between serum matrix metalloproteinases-9 (MMP-9) levels and prognosis of acute ischemic stroke.We measured MMP-9 in 3,186 participants (2,008 men 1,178 women) from China Antihypertensive Trial Acute Ischemic Stroke (CATIS). Study outcome data on death, major disability (modified Rankin Scale score ≥3), vascular disease were collected at 3 months after stroke onset.During follow-up, 767 (24.6%) experienced or died. Serum was significantly associated with an...
Abstract Background Triglyceride glucose (TyG) index was recently reported to be associated with an increased risk of the development and recurrence cardiovascular events, atherosclerosis is a main speculative mechanism. However, data on relationship between TyG atherosclerosis, especially in setting ischemic stroke, rare. We aimed explore association carotid patients stroke. Methods A total 1523 stroke artery imaging were enrolled this analysis. The calculated as ln [fasting triglyceride...
Remnant cholesterol makes great contribution to residual risk of cardiovascular disease, but population-based evidence on the relationship between remnant and atherosclerosis is rare. Common carotid artery intima-media thickness (cIMT) an imaging marker subclinical atherosclerosis. We aimed explore association levels cIMT in patients with ischemic stroke.One thousand four hundred ninety-six stroke baseline serum lipids data were included this analysis. Fasting was calculated as total minus...
Choline metabolism was suggested to play pathophysiological roles in nervous system and atherosclerosis development. However, little is known about the impacts of choline pathway nutrients metabolites on poststroke cognitive impairment. We aimed prospectively investigate relationships between circulating choline, betaine, trimethylamine N-oxide with impairment among acute ischemic stroke patients.We derived data from CATIS (China Antihypertensive Trial Acute Ischemic Stroke). Plasma...
Background The impact of serum matrix metalloproteinases‐9 (MMP‐9) on cognitive impairment after ischemic stroke is unclear. We aimed to investigate the association between MMP‐9 in short‐term acute phase and at 3 months. Methods Results Our study was based a subsample from CATIS (China Antihypertensive Trial Acute Ischemic Stroke); total 558 patients with levels 7 26 participating sites trial were included this analysis. Cognitive severity categorized as severe, mild, or none (Mini‐Mental...
Background:Prior studies have shown an association between high blood urea nitrogen (BUN) and elevated risk of mortality in heart failure patients, but data on the prognostic significance BUN other markers kidney function acute ischemic stroke (AIS) patients are sparse.
Background Epidemiological studies have reported discrepant findings on the relationship between education level and outcomes after stroke. We aimed to prospectively investigate mortality, recurrent stroke, cardiovascular events in Chinese patients with ischemic Methods Results included 3861 participants from China Antihypertensive Trial Acute Ischemic Stroke. Education was categorized as illiteracy, primary school, middle college. Study were all-cause stroke-specific within 2 years A...
Clinically significant changes in neurological deficits frequently occur after stroke onset, reflecting further injury or improvement. However, the National Institutes of Health Stroke Scale (NIHSS) score is only evaluated once most studies, usually at onset. Utilizing repeated measures NIHSS scores to identify different trajectories function may be more informative and provide useful predictive information. We determined association with long-term clinical outcomes ischemic stroke.A total...
To compared the effect of early antihypertensive treatment started within 24-48 h stroke onset versus delaying until day eight on reducing dependency or death.Multicentre, randomised, open label trial.106 hospitals in China between 13 June 2018 and 10 July 2022.4810 patients (≥40 years) were enrolled with acute ischaemic symptom elevated systolic blood pressure 140 mm Hg <220 Hg.Patients randomly assigned to receive immediately after randomisation (aimed at by 10%-20% first 24 a mean <140/90...
Objective To examine the associations between occupation, sleep duration and quality. Methods The data for this study was extracted from collected 2008 Chinese Sub-optimal Health Study. Our sample consisted of 18,316 subjects aged 18-65. Occupation other relevant characteristics to were collected. We used Pittsburgh Sleep Quality Index (PSQI) measure quality multiple logistic regression models association occupation with shortened poor Results Farmers had longest (mean=8.22 hours) while...
Objective— Serum Dkk-1 (dickkopf-1) level has been shown to be elevated in patients with ischemic stroke, but its impact on clinical outcomes of stroke remains unclear. The aim this study is investigate the association between serum and prognosis stroke. Approach Results— We measured levels 3178 from CATIS (China Antihypertensive Trial Acute Ischemic Stroke). primary outcome was a combination all-cause mortality major disability (modified Rankin scale score, ≥3) at 1 year after Secondary...
Background and Purpose- Previous experimental studies suggested that serum netrin-1 was associated with the progression of ischemic stroke. Knowledge about among stroke patients may provide new ideas for prognostic assessment The aim this study to investigate association between prognosis Methods- Serum levels at baseline were measured 3346 from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke), all followed up 3 months after onset. primary outcome a combination death major...
Background and Purpose: Complement C3 has been implicated in inflammation ischemia/reperfusion injury, but its impact on the prognosis of ischemic stroke remains unclear. Aim this study was to prospectively investigate association between serum complement adverse clinical outcomes after stroke. Methods: We measured levels for 3474 patients with 26 participating hospitals collected data at 3 months The primary outcome composite death major disability (modified Rankin Scale score ≥3) onset...
Patients with stroke are often affected by varying degrees of functional disability and have different evolution patterns in disability. However, little is known about the predictive usefulness changes after stroke. We aimed to describe 1-year trajectories assess associations longitudinal 24-month clinical outcomes ischemic
Poststroke cognitive impairment is a severe and common clinical complication that constitutes substantial global health burden. We aimed to evaluate the association of 3 cardiac biomarkers in combination with poststroke their prognostic significance.
BACKGROUND: We performed a prespecified subgroup analysis of the CATIS-2 trial (China Antihypertensive Trial in Acute Ischemic Stroke II) to compare effect early versus delayed antihypertensive treatment on death and disability patients with without medical history hypertension. METHODS: is multicenter randomized clinical conducted 106 hospitals China. The 4810 acute ischemic stroke within 24 48 hours symptom onset elevated systolic blood pressure between 140 <220 mm Hg receive...
Background Whether mean arterial pressure (MAP) and pulse (PP), two indicators of cerebral perfusion, could guide the selection anti-hypertensive strategies after acute ischaemic stroke remains uncertain. Our study was to explore impact early intervention on adverse clinical outcomes following stratified by levels MAP PP based China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). Methods The trial randomised 4071 patients with elevated systolic blood (SBP) receive treatment...
Objectives To assess the association between plasma homocysteine (Hcy), blood pressure (BP) and poor outcome at hospital discharge among acute ischemic stroke patients, if high Hcy increases risk of based on BP status in a northern Chinese population. Methods Between June 1, 2009 May 31, 2013, total 3695 patients were recruited from three hospitals cities. Demographic characteristics, lifestyle factors, medical history, other clinical characteristics recorded for all subjects. Poor was...
Background and Purpose— Elevated galectin-3 has been associated with atherosclerosis poor outcomes in patients heart failure. However, it remains unclear whether any effect on the of ischemic stroke. The aim present study was to examine association between among acute Methods— Serum measured 3082 primary outcome a combination death or major disability (modified Rankin Scale score, ≥3) at 3 months after Results— Compared lowest quartile galectin-3, multivariate adjusted odds ratios (95%...