A5064304964- Inflammasome and immune disorders
- Medical Research and Treatments
- Blood Pressure and Hypertension Studies
- Traditional Chinese Medicine Studies
- Neurological Disease Mechanisms and Treatments
- Cancer survivorship and care
- Neuroinflammation and Neurodegeneration Mechanisms
- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Cancer, Hypoxia, and Metabolism
- Respiratory viral infections research
- Acute Kidney Injury Research
- Hematopoietic Stem Cell Transplantation
- Acute Ischemic Stroke Management
- Pleural and Pulmonary Diseases
- Tryptophan and brain disorders
- Childhood Cancer Survivors' Quality of Life
- Myasthenia Gravis and Thymoma
- Chronic Kidney Disease and Diabetes
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Spinal Cord Injury Research
First Affiliated Hospital of Jiangxi Medical College
2025
Heilongjiang University of Chinese Medicine
2007-2025
Singapore General Hospital
2019-2025
West China Second University Hospital of Sichuan University
2020-2024
Sichuan University
2017-2024
Tulane University
2014-2024
Nanjing University of Chinese Medicine
2013-2024
Nanjing General Hospital of Nanjing Military Command
2023-2024
University of New Orleans
2016-2024
First Affiliated Hospital Zhejiang University
2011-2024
Remimazolam is a novel benzodiazepine γ-aminobutyric acid A (GABAa) receptor agonist used for sedation and the induction as well maintenance of general anesthesia. Previous research proved that anesthetic agents acting on GABAa receptor, such thiopentone, propofol midazolam, have protective actions cerebral ischemia/reperfusion (I/R) injury. We here probed into remimazolam its effect potential mechanism action against I/R injury.A rat model middle artery occlusion (MCAO) with focal transient...
Lactate elevation is a well-characterized biomarker of mitochondrial dysfunction, but its role in diabetic kidney disease (DKD) not well defined. Urine lactate was measured patients with type 2 diabetes (T2D) 3 cohorts (HUNT3, SMART2D, CRIC). and plasma were during euglycemic hyperglycemic clamps participants 1 (T1D). Patients the HUNT3 cohort DKD had elevated urine levels compared age- sex-matched controls. In SMART2D CRIC cohorts, third tertile lactate/creatinine associated more rapid...
Duchenne muscular dystrophy (DMD) affects both skeletal and cardiac muscle. It is currently unclear whether the strategies developed for muscle can ameliorate cardiomyopathy. Synthetic mini-/micro-dystrophin genes have yielded impressive protection in animal models. The 6-kb DeltaH2-R19 minigene particularly promising because it completely restores force to wild-type levels. Here, we examined expressing this heart, but not muscle, could normalize function mdx model of DMD Transgenic mice...
Background The impact of serum matrix metalloproteinases‐9 (MMP‐9) on cognitive impairment after ischemic stroke is unclear. We aimed to investigate the association between MMP‐9 in short‐term acute phase and at 3 months. Methods Results Our study was based a subsample from CATIS (China Antihypertensive Trial Acute Ischemic Stroke); total 558 patients with levels 7 26 participating sites trial were included this analysis. Cognitive severity categorized as severe, mild, or none (Mini‐Mental...
Objective To understand the clinical effectiveness and safety of Shufeng Jiedu Capsules combined with umifenovir (Arbidol) in treatment common-type COVID-19.
Objective: The objective of this study was to investigate the roles and mechanisms inflammatory mediators NLRP3 IL-1β in refractory temporal epilepsy brain injury. Method: First, tissue peripheral blood children undergoing intractable lobe surgery were analyzed as research objects. expression levels measured. A model established using wild-type knockout 129 mice. Pilocarpine injected intraperitoneally into experimental group, isovolumetric saline control group (n = 8 each group). blood,...
Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation injury, thus producing protective effect in the injured cord. A mouse model T9 contusive was established using an Infinite Horizon Impactor, and VX-765, selective inhibitor caspase-1, administered for 7 successive days The results showed that: (1) VX-765 inhibited injury-induced interleukin-1β interleukin-18 secretion. (2) After increase...
Abstract Diabetes mellitus (DM) damages male reproduction at multiple levels, such as endocrine secretion, spermatogenesis and penile erection. We herein investigated the protective effects mechanism of loganin targeting advanced glycation end products (AGEs)/receptor for AGEs (RAGE)/p38 mitogen‐activated protein kinase (p38MAPK)/NF‐κB signalling pathway. Loganin relieved general DM symptoms decreased blood glucose level KK‐Ay mice. Haematoxylin‐eosin staining demonstrated that ameliorated...
After spinal cord injury (SCI), destructive immune cell subsets are dominant in the local microenvironment, which important mechanism of injury. Studies have shown that inflammasomes play an role inflammation following SCI, and apoptosis-associated speck-like protein containing a card (ASC) is adaptor shared by inflammasomes. Therefore, we speculated inhibiting ASC may improve microenvironment injured cord. Here, CRID3, blocker oligomerization, was used to study its effect on possible...
This case report examines the challenges associated with removing a totally implantable venous access port (TIVAP) used for long-term chemotherapy in patient breast cancer. Prolonged use of TIVAPs can result complications such as catheter kinking, thrombosis, and adhesions between surrounding tissues, potentially complicating their removal. A cancer bone metastasis presented difficulty aspirating blood from TIVAP that had been placed right internal jugular vein 3 years. Initial removal...
Abstract Age‐related cognitive impairment (ARCI) is linked to β‐amyloid (Aβ) accumulation and disrupted blood‐brain barrier (BBB) transport via receptors for advanced glycation end products (RAGE) low‐density lipoprotein receptor‐related protein 1 (LRP1). This study examines electroacupuncture (EA) effects on cognition, hippocampal pathology, neurotransmitters, the RAGE/LRP1 system in senescence‐accelerated mouse prone 8 (SAMP8) mice. EA at Zusanli (ST36) Baihui (GV20) improved performance,...
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Learning and memory disorders decreased neuroplasticity are the main clinical manifestations of age-induced cognitive dysfunction. Orexin A (OxA) has been reported to show abnormally elevated expression in cerebrospinal fluid (CSF) patients with Alzheimer's disease (AD) be associated impairment. Here, we further assessed whether excitatory neurotransmitter OxA is involved function senescence-accelerated mouse prone 8 (SAMP8) mice. In this study, investigated mechanism by using behavioral...
J. Neurochem. (2010) 113 , 1555–1564. Abstract Enkephalin (ENK) has been implicated in nociceptive transmission the spinal cord while its functional role is not clear because of difficulties ideally visualizing ENKergic neurons. We thus developed preproenkephalin–green fluorescent protein transgenic mice to better identify Real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR) together with immunohistochemistry and situ hybridization were first employed confirm successful...