A5102007218- Immune Cell Function and Interaction
- Nicotinic Acetylcholine Receptors Study
- Psoriasis: Treatment and Pathogenesis
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Reproductive System and Pregnancy
- Vagus Nerve Stimulation Research
- Receptor Mechanisms and Signaling
- Inflammatory Bowel Disease
- Cancer Immunotherapy and Biomarkers
- Calcium signaling and nucleotide metabolism
- Ginseng Biological Effects and Applications
- Adipose Tissue and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Cancer Mechanisms and Therapy
- Mitochondrial Function and Pathology
- Connexins and lens biology
- Traditional Chinese Medicine Analysis
- Bacterial biofilms and quorum sensing
- ATP Synthase and ATPases Research
- Clostridium difficile and Clostridium perfringens research
- Colorectal Cancer Treatments and Studies
- Fibroblast Growth Factor Research
Guangzhou University of Chinese Medicine
2015-2024
The University of Texas Health Science Center at San Antonio
1997-1998
Sinomenine (SIN), an alkaloid extracted from the Chinese herbal medicine Sinomenium acutum, has great potential in anti-inflammatory, immune regulation, analgesic and sedative, is already a clinical drug for treatment of rheumatoid arthritis China. Our previous studies show SIN inhibits inflammation by regulating ɑ7nAChR, key receptor cholinergic anti-inflammatory pathway (CAP), which plays important role peripheral central nervous system inflammation. Growing evidence supports dysregulation...
Resveratrol is a phytoalexin with beneficial effects on human health. The aim of the present study was to investigate resveratrol endothelial dysfunction involved in insulin signaling and inflammation. Endothelial cells were stimulated palmitate (PA) induce resistance characterized by loss insulin-mediated nitric oxide (NO) production. Diabetes induced rats fructose feeding. mechanisms investigated using an aortic relaxation assay Western blot analysis. In cells, 0.1-10 μmol/L suppressed IκB...
The neuronal nicotinic acetylcholine receptor gene family consists of 11 members, α2–α9 and β2–β4. Three the genes, those encoding α3, α5, β4 subunits, are clustered tightly within genome. These three subunits constitute predominant subtype expressed in peripheral nervous system. genomic proximity genes suggests a regulatory mechanism ensuring their coordinate expression. However, it is likely that gene-specific mechanisms also functioning because expression patterns although similar, not...
Objective: This study aims to investigate the effect of astragaloside Ⅳ on adipose lipolysis and hepatic gluconeogenesis. Methods: High-fat diet (HFD) feeding induced dysfunction with enhanced endogenous glucose production in mice. The effects Astragaloside were investigated. Results: HFD cAMP accumulation through reducing PDE3B expression activity tissue. As a result, increased Akt phosphorylation promoted binding preserve content, resultantly accumulation. Knockdown Akt1/2 diminished...
Isoorientin has anti-inflammatory effects; however, the mechanism remains unclear. We previously found isoorientin is an inhibitor of glycogen synthase kinase 3β (GSK3β) in vitro. Overactivation GSK3β associated with inflammatory responses. inactivated by phosphorylation at Ser9 (i.e., p-GSK3β). Lithium chloride (LiCl) inhibits and also increases p-GSK3β (Ser9). The present study investigated effect via regulation lipopolysaccharide- (LPS-) induced RAW264.7 murine macrophage-like cells...
Drug efflux systems contribute to the intrinsic resistance of Pseudomonas aeruginosa many antibiotics and biocides hamper research focused on discovery development new antimicrobial agents targeted against this important opportunistic pathogen. Using a P. PAO1 derivative bearing deletions opmH, encoding an outer membrane channel for substrates, four pumps belonging nodulation/cell division class including mexAB-oprM, we identified small-molecule indole-class compound (CBR-4830) that is...
Nicotinic acetylcholine receptors constitute a multigene family (α2–α9, β2–β4) expressed in discrete temporal and spatial patterns within the nervous system. The are critical for proper signal transmission between neurons their targets. molecular mechanisms underlying receptor gene expression have not been completely elucidated but clearly involve regulation at level of transcription. We previously identified novel 19-base pair (bp) transcriptional regulatory element promoter region rat β4...
Colitis-associated cancer (CAC) is a malignant disease of the colon that caused by recurrent episodes chronic intestinal inflammation. Huangqi Baizhu decoction (HBD) classic prescription comprised Radix Astragali and Rhizoma Atractylodis, which are usually used to treat digestive conditions, such as peptic ulcers, colitis, or colorectal carcinoma in clinics. HBD well known for "tonifying qi spleen" based on theories traditional Chinese medicine, has preponderant effect alleviating mucosa...
Abstract Background Interleukin (IL)-6/signal transducers and activators of transcription 3 (STAT3) signaling plays an important role in the development colitis-associated colorectal cancer (CAC). The mechanism CAC formation remains unclear, relationship between miRNAs IL-6/STAT3 pathway is not well understood. In this study, we investigated miR-29a-5p alterations 10-11 translocations (TETs) regulated by network. Methods was screened a mouse model high-throughput microarray analysis human...
ABSTRACT Ulcerative colitis (UC) is a gastrointestinal disease. The link between gut microbiota and the inflammatory response in has been recently established. Restoration of suppresses signaling. Kuijieling (KJL) decoction, an experimental Chinese medicine formula could ameliorate symptom colitis. However, involvement its curative effect remains known. Here, we would like to assess therapeutic KJL DSS-induced UC model. Mouse feces were collected, followed by 16S rRNA sequencing. decoction...
Colorectal cancer (CRC) is a malignancy that arises within the gastrointestinal tract. Despite ongoing research, etiology and pathogenesis of CRC remain elusive; particularly, distribution characteristics tumor-associated macrophages currently an active area investigation in understanding pathological progression prevention CRC.
Oxidative stress can cause the excessive generation of reactive oxygen species (ROS) and has various adverse effects on muscular mitochondria. Qiangji Jianli decoction (QJJLD) is an effective traditional Chinese medicine (TCM) that widely applied to improve muscle weakness, it active constituents prevent mitochondrial dysfunction. To investigate protective mechanism QJJLD against hydrogen peroxide‐ (H 2 O ‐) mediated dysfunction in L6 myoblasts. Cell viability was determined with MTT assay....
Sinomenine (SIN) is a clinical drug for treating rheumatoid arthritis (RA) in China. Our previous study found SIN inhibited inflammation via alpha7 nicotinic acetylcholine receptor (α7nAChR) macrophages vitro. Adenosine A2A has anti-inflammatory and immunosuppressive function. However, the mechanisms of acting on α7nAChR effect adenosine (A2A R) RA are not clear. In present study, effects adjuvant-induced-arthritis (AIA) rats vivo fibroblast-like synoviocytes (FLSs) vitro were investigated....
To investigate the effect of Kuijieling (KJL) on balance between T helper 17 (Th17) and regulatory (Treg) cells in peripheral blood mononuclear (PBMC) vitro explore underlying mechanism.PBMCs isolated from rats were stimulated with transforming growth factor-β, interleukin (IL)-6, IL-23 to induce imbalance Th17 Treg treated 10, 5, or 2.5% KJL-containing serum. The proportion CD4+ was analyzed by flow cytometry, concentrations IL-17, IL-21, IL-10 assayed ELISA, mRNA expressions retinoic...