A5080360711- Myasthenia Gravis and Thymoma
- Mitochondrial Function and Pathology
- Parkinson's Disease and Spinal Disorders
- Antifungal resistance and susceptibility
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- ATP Synthase and ATPases Research
- Nanocluster Synthesis and Applications
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Studies
- Salivary Gland Disorders and Functions
- Glycogen Storage Diseases and Myoclonus
- RNA modifications and cancer
- Adenosine and Purinergic Signaling
- Peripheral Neuropathies and Disorders
- Supramolecular Self-Assembly in Materials
- Cancer Treatment and Pharmacology
- Advanced Nanomaterials in Catalysis
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Conducting polymers and applications
- Genetic Neurodegenerative Diseases
- Adipose Tissue and Metabolism
Guangzhou University of Chinese Medicine
2018-2024
Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. Because of complex pathogenesis AD and unique location lesions, effective clinical treatment strategies for this remain elusive. However, development nanotechnology has allowed a new era to emerge. nanomedicines are products interdisciplinary research that enable high precision targeted delivery. Additionally, they can specifically regulate various pathogenic factors. This review focuses on based...
Myasthenia gravis (MG) is a rare chronic autoimmune disease caused by the production of autoantibodies against postsynaptic membrane receptors present at neuromuscular junction. This condition characterized fatigue and muscle weakness, including diplopia, ptosis, systemic impairment. Emerging evidence suggests that in addition to immune dysregulation, pathogenesis MG may involve mitochondrial damage ferroptosis. Mitochondria are primary site energy production, reactive oxygen species (ROS)...
Functional disorders of mitochondria are closely related to muscle diseases. Many studies have also shown that oxidative stress can stimulate the production a large number reactive oxygen species (ROS), which various adverse effects on and damage cells.In this study, based our previous research, we focused PINK1/Parkin pathway explore mechanism by AS-IV alleviates injury inhibiting excessive mitophagy.L6 myoblasts were treated with after stimulation hydrogen peroxide (H2O2) carbonyl cyanide...
Astragaloside IV (AS‑IV) has various pharmacological effects, including antioxidant and immunoregulatory properties, which can improve myasthenia gravis (MG) symptoms. However, the potential mechanism underlying effects of AS‑IV on MG remains to be elucidated. The present study aimed investigate whether a therapeutic effect its action. By subcutaneously immunizing rats with R97‑116 peptide, an experimental autoimmune (EA) rat model was established. (40 or 80 mg/kg/day) treatment then applied...
Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by the production of antibodies against acetylcholine receptors (AChRs). Qiangji Jianli (QJJL) decoction effective traditional Chinese medicine (TCM) that used to treat MG. Our study aimed investigate effect QJJL on MG and clarify mechanism which regulates mitochondrial energy metabolism fusion fission (MFF). SPF female Lewis rats were administered Rat 97-116 peptides induce experimental myasthenia (EAMG). The...
Due to challenges in diagnosing myasthenia gravis (MG), identifying novel diagnostic biomarkers for this disease is essential. Mitochondria are key organelles that regulate multiple physiological functions, such as energy production, cell proliferation and death. In the present study, Mfn1/2, Opa1, Drp1, Fis1, AMPK, PGC-1α, NRF-1 TFAM were compared between patients with MG healthy subjects identify potential MG. Blood samples collected from 50 subjects. The participants' demographic...
The Qiangji Jianli Decoction (QJJLD) is an effective Chinese medicine formula for treating Myasthenia gravis (MG) in the clinic. QJJLD has been proven to regulate mitochondrial fusion and fission of skeletal muscle myasthenia gravis. In this study, we investigated whether plays a therapeutic role regulating biogenesis MG explored underlying mechanism. Rats were experimentally induced establish autoimmune (EAMG) by subcutaneous immunization with R97–116 peptides. treatment groups administered...
Oxidative stress can cause the excessive generation of reactive oxygen species (ROS) and has various adverse effects on muscular mitochondria. Qiangji Jianli decoction (QJJLD) is an effective traditional Chinese medicine (TCM) that widely applied to improve muscle weakness, it active constituents prevent mitochondrial dysfunction. To investigate protective mechanism QJJLD against hydrogen peroxide‐ (H 2 O ‐) mediated dysfunction in L6 myoblasts. Cell viability was determined with MTT assay....
<title>Abstract</title> Myasthenia gravis (MG), a rare autoimmune disorder, presents complex pathogenesis involving various immune molecules. The modification of N6-methyladenosine (m6A) regulates diverse metabolic and immunopathological processes; however, its role in MG remains unclear. We downloaded dataset GSE85452 from the GEO database to identify differentially expressed genes regulated by m6A. Random Forest (RF) method was utilized pivotal regulatory associated with m6A modification....