A5044146211- Myasthenia Gravis and Thymoma
- Mitochondrial Function and Pathology
- Parkinson's Disease and Spinal Disorders
- ATP Synthase and ATPases Research
- Adipose Tissue and Metabolism
- Cancer Genomics and Diagnostics
- Autophagy in Disease and Therapy
- Cardiovascular Disease and Adiposity
- Retinal Diseases and Treatments
- Sirtuins and Resveratrol in Medicine
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cancer Treatment and Pharmacology
- Glycogen Storage Diseases and Myoclonus
- Ferroptosis and cancer prognosis
- Antifungal resistance and susceptibility
- Salivary Gland Disorders and Functions
- Pancreatic and Hepatic Oncology Research
The Seventh Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Guangzhou University of Chinese Medicine
2020-2024
China Medical University
2024
Jiujiang First People's Hospital
2023
Pancreatic adenocarcinoma (PAAD) is a highly aggressive cancer with poor prognosis, reliable markers are urgently needed for early detection and prognosis evaluation. SAPCD2, cell cycle related gene, has been implicated in tumorigenesis proposed as potential therapeutic target cancer. However, no comprehensive study explored its expression regulation, discussed role tumor immune modulation, along therapy response pan-cancer until now. SAPCD2 was analyzed using data from The Cancer Genome...
Diabetes retinopathy (DR) is a chronic, progressive, and potentially harmful retinal disease associated with persistent hyperglycemia. Autophagy lysosome-dependent degradation pathway that widely exists in eukaryotic cells, which has recently been demonstrated to participate the DR development. Stachydrine (STA) water-soluble alkaloid extracted from Leonurus heterophyllus. This study aimed explore effects of STA on autophagy progression vivo vitro.High glucose-treated human microvascular...
Astragaloside IV (AS‑IV) has various pharmacological effects, including antioxidant and immunoregulatory properties, which can improve myasthenia gravis (MG) symptoms. However, the potential mechanism underlying effects of AS‑IV on MG remains to be elucidated. The present study aimed investigate whether a therapeutic effect its action. By subcutaneously immunizing rats with R97‑116 peptide, an experimental autoimmune (EA) rat model was established. (40 or 80 mg/kg/day) treatment then applied...
Due to challenges in diagnosing myasthenia gravis (MG), identifying novel diagnostic biomarkers for this disease is essential. Mitochondria are key organelles that regulate multiple physiological functions, such as energy production, cell proliferation and death. In the present study, Mfn1/2, Opa1, Drp1, Fis1, AMPK, PGC-1α, NRF-1 TFAM were compared between patients with MG healthy subjects identify potential MG. Blood samples collected from 50 subjects. The participants' demographic...
The Qiangji Jianli Decoction (QJJLD) is an effective Chinese medicine formula for treating Myasthenia gravis (MG) in the clinic. QJJLD has been proven to regulate mitochondrial fusion and fission of skeletal muscle myasthenia gravis. In this study, we investigated whether plays a therapeutic role regulating biogenesis MG explored underlying mechanism. Rats were experimentally induced establish autoimmune (EAMG) by subcutaneous immunization with R97–116 peptides. treatment groups administered...
It is well known that epicardial adipose tissue (EAT) associated with the development of atrial fibrillation (AF). The aim this study was to investigate whether EAT density (EAT-d) new-onset (POAF) after aortic valve replacement (AVR).
Oxidative stress can cause the excessive generation of reactive oxygen species (ROS) and has various adverse effects on muscular mitochondria. Qiangji Jianli decoction (QJJLD) is an effective traditional Chinese medicine (TCM) that widely applied to improve muscle weakness, it active constituents prevent mitochondrial dysfunction. To investigate protective mechanism QJJLD against hydrogen peroxide‐ (H 2 O ‐) mediated dysfunction in L6 myoblasts. Cell viability was determined with MTT assay....