A5102027148- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Barrier Structure and Function Studies
- Medical Research and Treatments
- Acupuncture Treatment Research Studies
- Cancer Mechanisms and Therapy
- Traditional Chinese Medicine Studies
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal motility and disorders
- Ginger and Zingiberaceae research
- Eosinophilic Esophagitis
- Free Radicals and Antioxidants
- Food Quality and Safety Studies
- Cancer, Lipids, and Metabolism
- Dermatology and Skin Diseases
- Immune cells in cancer
- Colorectal Cancer Screening and Detection
- Phagocytosis and Immune Regulation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Myasthenia Gravis and Thymoma
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2013-2024
Lanzhou University
2021-2024
Lanzhou University Second Hospital
2021-2024
First Hospital of Lanzhou University
2023
Guangzhou University of Chinese Medicine
2019-2021
Chongqing Medical University
2014
University of Helsinki
2003
Abstract More than 80% of patients with myasthenia gravis (MG) are positive for anti-acetylcholine receptor (AChR) antibodies. Regulatory T cells (Tregs) suppress overproduction these antibodies, and AChR antibody-positive MG (AChR MG) exhibit impaired Treg function reduced numbers. The gut microbiota their metabolites play a crucial role in maintaining differentiation function. However, whether Tregs correlate activity remains unknown. Here, we demonstrate that butyric acid-producing...
Background/Aims: Irritable bowel syndrome with diarrhoea (IBS-D) is a chronic, functional disorder characterized by abdominal pain or and altered habits, which correlate intestinal hyperpermeability. MicroRNAs (miRNAs) are involved in regulating permeability IBS-D. However, the role of miRNAs protecting epithelial barrier remains unclear. Our goals were to (i) identify differential expression their targets distal colon IBS-D rats; (ii) verify vitro whether occludin (OCLN) zonula occludens 1...
Background. Gastric cancer (GC), an extremely aggressive tumor with a very different prognosis, is the third leading cause of cancer-related mortality. We aimed to construct ferroptosis-related prognostic model that can be distinguished prognostically. Methods. The gene expression and clinical data GC patients were downloaded from Cancer Genome Atlas (TCGA) Gene Expression Omnibus database (GEO). genes obtained FerrDb. Using “limma” R package univariate Cox analysis, differential value...
To investigate effects of berberine exerts on A20 expression and regulation intestinal epithelial tight junctions via the TNF-α-NF-κB-MLCK pathway in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D). C57BL/6 wild type (WT) IEC-KO mice (48 each) were randomly divided into normal control (NC), model (MC), rifaximin groups (12 per group). An experimental IBS-D was established using 4% acetic acid evaluated by haematoxylin-eosin (HE) staining. treated with berberine, respectively....
BACKGROUND: Gastric cancer (GC) is the fourth most common cause of cancer-related deaths in world and 5-year overall survival (OS) rate less than 10%. So, it urgent to identified novel diagnostic prognostic biomarkers.METHODS: Twelve GEO (gene expression omnibus) datasets were obtained from Gene Expression Omnibus database. Differentially expressed genes (DEGs) between GC normal tissues screened integrated using limma RobustRankAggreg (RRA) packages R software. Protein-protein interaction...
Serum exosomal microRNAs (miRNAs) have been suggested as novel biomarkers for various diseases, especially gastric cancer (GC). But circulating Chronic atrophic gastritis (CAG) which is defined precancrerous lesions of GC remain largely elusive. To investigate serum miRNAs that are differently expressed in CAG patients and nonatrophic (CNAG) may be helpful its diagnosis therapy.Patients were recruited according to the exclusioncriteria. RNA was extracted from exosomes 30 CNAG patients. The...
Background & Aims: Gastric cancer is the common malignancies from worldwide. Endoscopy currently most effective method to detect early gastric (EGC). However, endoscopy not infallible and EGC can be missed during endoscopy. Artificial intelligence (AI)-assisted endoscopic diagnosis a recent hot spot of research. We aimed quantify diagnostic value AI-assisted in diagnosing EGC. Method: The PubMed, MEDLINE, Embase Cochrane Library Databases were searched for articles on application...
Ferroptosis is a newly recognized form of regulatory cell death characterized by severe lipid peroxidation triggered iron overload and the production reactive oxygen species (ROS). However, role ferroptosis in acute pancreatitis(SAP) has not been fully elucidated. We established four pancreatitis models rats including sham control group, SAP Fer -1-treated (SAP + Fer-1) 3-MA-treated 3-MA) group. The group was induced retrograde injection sodium taurocholate into pancreatic duct. other two...
MicroRNAs (miRNAs) were reported to be responsible for intestinal permeability in diarrhea-predominant irritable bowel syndrome (IBS-D) rats our previous study. However, whether and how miRNAs regulate visceral hypersensitivity IBS-D remains largely unknown.We established the rat model evaluated it using nociceptive test, myeloperoxidase activity assay, restraint stress-induced defecation, electromyographic (EMG) activity. The distal colon was subjected miRNA microarray analysis followed by...
Ginger or ginger extracts have been used in traditional medicine relieve pain caused by diarrhea predominant irritable bowel syndrome (IBS-D), but few data exists about its effectiveness. This present study was to validate the effect of on visceral pain, and further explore possible underlying mechanism which is IBS-D intestinal hypersensitivity.
Gentiopicroside (GPS) is a highly water-soluble small-molecule drug and the main bioactive secoiridoid glycoside of Gentiana scabra that has been shown to have hepatoprotective effects against non-alcoholic steatohepatitis (NASH), form fatty liver disease (NAFLD) can progress cirrhosis hepatocellular carcinoma. However, GPS on NASH underlying mechanisms remain obscure. Firstly, high-fat, high-cholesterol (HFHC) diet high-sugar solution containing d-fructose d-glucose were used establish...
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease. The dysregulated immune system plays an important role in the pathogenesis of AS. Myeloid-derived suppressor cells (MDSCs) play key immunoregulatory autoimmune arthritis. aim this study was to clarify underlying mechanism MDSCs patients with Flow cytometry used analyze phenotype among peripheral blood mononuclear (PBMCs) from 46 AS and healthy control subjects. correlation between MDSC frequency disease index evaluated....
Objectives: The purpose of this study was to investigate the role 13 m5C-related regulators in colon adenocarcinoma (COAD) and determine their prognostic value. Methods: Gene expression clinicopathological data were obtained from Cancer Genome Atlas (TCGA) datasets. analyzed with characteristics alterations within regulators. Subsequently, different subtypes patients COAD identified. Then, value confirmed via univariate Cox regression least absolute shrinkage selection operator (LASSO)...
Inflammatory bowel disease (IBD), denominated by Crohn's and ulcerative colitis, is often associated with abdominal pain, diarrhea bloody stool. The standard protocols for treating colitis conditions are not satisfactory; thus, complementary alternative medicines have been increasingly accepted IBD sufferers worldwide. In this study, we aimed to elucidate the anti-inflammatory effect of Chang-An-Shuan (CAS), a 6-herb Chinese medicinal formula, on 2, 4, 6-trinitrobenzenesulfonic acid...
Due to challenges in diagnosing myasthenia gravis (MG), identifying novel diagnostic biomarkers for this disease is essential. Mitochondria are key organelles that regulate multiple physiological functions, such as energy production, cell proliferation and death. In the present study, Mfn1/2, Opa1, Drp1, Fis1, AMPK, PGC-1α, NRF-1 TFAM were compared between patients with MG healthy subjects identify potential MG. Blood samples collected from 50 subjects. The participants' demographic...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a fatal malignancy owing to the lack of effective tools predict overall survival (OS). MicroRNAs (miRNAs) play an important role in HNSCC occurrence, development, invasion metastasis, significantly affecting OS patients. Thus, construction miRNA-based risk signatures nomograms desirable patients with HNSCC. Accordingly, present study, miRNA sequencing data 71 13 normal samples downloaded from The Cancer Genome Atlas (TCGA)...
Abstract A method was developed to measure the radicalscavenging activity of compounds separated by reversed‐phase TLC (RP‐TLC) using phenolic acids as model analytes. separation followed dipping plate in a 0.04% (wt/vol) solution 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) methanol. The possessing radical‐scavenging were detected bright yellow bands against purple background. video documentation system based on CCD camera used for detection and quantification activity. RP‐TLC‐DPPH compared widely...
We aim to explore the potential anti-HCC mechanism of Scutellaria barbata through integrated bioinformatics analysis.We searched active ingredients and related targets via TCMSP database, PubChem SwissTargetPrediction database. Then, we identified HCC disease from GEO dataset by WGCNA. Next, intersected drug were input into STRING database construct PPI networking in order obtain therapeutic barbata. Cytoscape software was used carry out network topology analysis targets. R package for GO...
Rheumatoid arthritis (RA) is called "immortal cancer", and it affects the quality of life, disability rate even survival patients. This study aimed to observe clinical efficacy, adverse reactions intradermal acupuncture (IA) in treatment RA patients with liver kidney deficiency syndrome. 132 were split into an IA group a sham at 1:1 ratio. Both groups assessed before after intervention assessments: traditional Chinese medicine (TCM) syndrome evaluation, Health Assessment Questionnaire (HAQ),...