A5100445637- Bone and Joint Diseases
- Marine Sponges and Natural Products
- Estrogen and related hormone effects
- Traditional Chinese Medicine Analysis
- Alzheimer's disease research and treatments
- Air Quality and Health Impacts
- Neuroendocrine Tumor Research Advances
- MicroRNA in disease regulation
- Smoking Behavior and Cessation
- Cancer-related molecular mechanisms research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Cardiac Fibrosis and Remodeling
- Hip disorders and treatments
- Bone health and treatments
- Cancer Cells and Metastasis
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetic Foot Ulcer Assessment and Management
- Flavonoids in Medical Research
- RNA modifications and cancer
- Health disparities and outcomes
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Synthesis and Biological Activity
Nanchang University
2023-2025
State Ethnic Affairs Commission
2025
Guangxi University
2025
Shandong University
2021-2024
Union Hospital
2021-2024
Huazhong University of Science and Technology
2021-2024
Guangzhou University of Chinese Medicine
2024
Taipei Medical University
2019-2024
Northeast Normal University
2024
Xijing Hospital
2013-2023
BackgroundSecondhand smoke exposure can cause morbidity and premature mortality. However, the global prevalence of, trends in, secondhand among adolescents are poorly documented. We aimed to assess from 1999 2018.MethodsWe did an analysis of most recent data Global Youth Tobacco Survey (GYTS), a nationally representative, self-administered, school-based cross-sectional survey tobacco use related factors aged 12–16 years worldwide. Data 142 countries territories that had done GYTS between...
OPINION article Front. Public Health, 27 May 2020Sec. Infectious Diseases – Surveillance, Prevention and Treatment Volume 8 - 2020 | https://doi.org/10.3389/fpubh.2020.00240
Abstract Purpose Recent clinical trials with agents targeting immune checkpoint pathway have emerged as an important therapeutic approach for a broad range of cancer types. Resveratrol has been shown to possess preventive and effects potential be chemotherapeutic agent/adjuvant. Here, we assessed the effect resveratrol on pathways. Methods The expression patterns Wnt components PD-L1 were examined by Western blot, Chromatin immunoprecipitation (ChIP) was used analysis DNA–protein...
To improve the oral absorption of relugolix (RLGL), which has low bioavailability due to its solubility and being a substrate P-glycoprotein (P-gp). A solid self-microemulsifying drug delivery system (RLGL-S-SMEDDS) was prepared evaluated in vitro vivo. The composition (S-SMEDDS) selected by study pseudo-ternary phase diagram, further optimized Design-Expert optimization design. RLGL-S-SMEDDS were terms particle size, zeta potential, morphology analysis, thermodynamic stability, release,...
Twelve new isocoumarins, spegazmarins A–L (1–12), including nine novel dimeric derivatives (1–9), three monomeric (10–12), as well eight known ones (13–20), were isolated from the endophytic fungus Spegazzinia sp. MDCW-573. Their structures elucidated by analysis of NMR, X-ray crystallography, and ECD data. Notably, isocoumarins (1–9) possess a unique linkage, where phenyl one monomer is connected to lactone another. The methods for determining configurations both within this class proposed,...
Apigenin (Api) is a plant monomer associated with reducing the risk of heart disease. However, mechanism action remains to be fully elucidated. In present study, it was hypothesized that API has cardioprotective effects by attenuating myocardial ischemia/reperfusion (I/R) injury. Rats were randomly subjected sham operation, I/R alone or + Api. Cardiac function measured, and infarct size evaluated triphenyltetrazolium chloride staining following reperfusion. The enzyme leakage analyzed for...
Non-coding RNAs, originally considered junk gene products, have taken center stage in view of their significant involvement a spectrum biological processes during human development, thereby offering novel therapeutic targets for improvement treatment options. Accumulating evidence has demonstrated non-coding RNA dysfunction across various cancers. In particular, microRNAs emerged as key regulatory molecules cancer biology. MicroRNAs are noninvasive, readily accessible biomarkers that can be...
The incidence of heart failure mainly resulting from cardiac hypertrophy and fibrosis increases sharply in post-menopausal women compared with men at the same age, which indicates a cardioprotective role estrogen. Previous studies our group have shown that novel estrogen receptor G Protein Coupled Receptor 30 (GPR30) could attenuate myocardial caused by ischemic disease. However, GPR30 ovariectomized mice has not been investigated yet. In this study, female bilateral ovariectomy or sham...
One of the leading causes death in world is cerebrovascular disease. Numerous Chinese traditional medicines, such as Cortex Moutan (root bark Paeonia suffruticosa Andrew) and Radix Salviae miltiorrhizae rhizome Salvia miltiorrhiza Bunge), protect against diseases exhibit anti-atherosclerotic effects. Traditional medicines have been routinely used for a long time China. In addition, these two herbs are prescribed together clinical practice. Therefore, pharmacodynamic interactions between...
This paper investigates the profile of COVID-19 cases in Hong Kong, highlighting unique age structure confirmed compared to other territories. While majority most territories around world have fitted an older profile, our analysis shows that positive Kong been concentrated among younger groups, with largest incidence reported 15–24 group. is despite population's rapidly aging and extremely high levels population density. Using detailed case data from Kong's Centre for Health Department...
Few studies have examined access to cigarettes among adolescents. To address this, we aimed examine cigarette and purchase patterns adolescent smokers based on the most recent data from Global Youth Tobacco Surveys (GYTS).
Endothelial impairment and dysfunction are closely related to the pathogenesis of steroid-associated osteonecrosis femoral head (SONFH). Recent studies have showed that hypoxia inducible factor-1α (HIF-1α) plays a crucial role in endothelial homeostasis maintenance. Dimethyloxalylglycine (DMOG) could suppress HIF-1 degradation result nucleus stabilization by repressing prolyl hydroxylase domain (PHD) enzymatic activity. Our results methylprednisolone (MPS) remarkably undermined biological...
Steroid-induced osteonecrosis of the femoral head (SONFH) is a progressive disease that leads to an increased disability rate. This study aimed ascertain biomarkers, infiltrating immune cells, and therapeutic drugs for SONFH. The gene expression profile GSE123568 dataset was downloaded from Gene Expression Omnibus (GEO) database. differentially expressed genes (DEGs) were identified using NetworkAnalyst platform. Functional enrichment, protein-protein interaction network (PPI), module...
The incidence of cardiovascular diseases was significantly increased in postmenopausal women. protection estrogen the system has been further reported for decades. Although menopausal hormone therapy used many clinical trials, debatable results indicate that studies elucidating precise molecular mechanism are urgently required. G protein-coupled receptor 30 (GPR30) is a membrane and displays protective roles diverse diseases. Previous have revealed ERK1/2-mediated MMP-9 signaling involved...