A5115603278- Medical Research and Treatments
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Influenza Virus Research Studies
- Traditional Chinese Medicine Analysis
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Virology and Viral Diseases
- Pharmacological Effects of Natural Compounds
- Pituitary Gland Disorders and Treatments
- Anorectal Disease Treatments and Outcomes
- Diverticular Disease and Complications
- Chronic Disease Management Strategies
- Lung Cancer Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Streptococcal Infections and Treatments
- Health and Wellbeing Research
- Circadian rhythm and melatonin
- Radiomics and Machine Learning in Medical Imaging
- Animal Virus Infections Studies
- Neurological Disease Mechanisms and Treatments
- Ophthalmology and Eye Disorders
- Frailty in Older Adults
Southwest Medical University
2022-2025
Chongqing University
2025
Gansu University of Traditional Chinese Medicine
2020-2025
Kunming Medical University
2025
Zhejiang Lab
2022-2025
Chongqing Medical University
2011-2024
Affiliated Hospital of Southwest Medical University
2023-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2011-2024
Wuhan No.1 Hospital
2020-2024
Kunming Children's Hospital
2012-2024
Abstract Human infections with avian influenza H7N9 or H10N8 viruses have been reported in China, raising concerns that they might cause human epidemics and pandemics. However, how these adapt to mammalian hosts is unclear. Here we show besides the commonly recognized viral polymerase subunit PB2 residue 627 K, other residues including 87E, 292 V, 340 588 648 V 676 M also play critical roles adaptation of virus. The avian-origin H10N8, H9N2 harboring PB2-588 exhibited higher activity, more...
To study the association between anthropometric indexes [lipid accumulation products (LAP), visceral obesity index (VAI), triglyceride and glucose (TyG) waist (WTI)] metabolic syndrome (MetS) in a representative sample of American adult population surveyed by National Health Nutrition Examination Survey (NHANES).Cross-sectional data from NHANES were used. Participants adults aged 18-80 y 1996-2006. MetS defined updated Cholesterol Education Program/Adult Treatment Panel III criteria...
Gastrodin is the main bioactive ingredient of a famous Chinese herb Rhizoma Gastrodiae. Many studies have reported that gastrodin has antioxidative and neuroprotective effects, although its effect on longevity mechanism neuroprotection not been well studied. Here, we use Drosophila melanogaster as model to investigate effects gastrodin. significantly extended lifespan, increased climbing ability, enhanced resistance oxidative stress, enzyme activities superoxide dismutase (SOD) catalase...
Co-infection of RNA viruses may contribute to their recombination and cause severe clinical symptoms. However, the tracking identification SARS-CoV-2 co-infection persist as challenges. Due lack methods for detecting co-infected samples in a large amount deep sequencing data, lineage composition, spatial-temporal distribution, frequency events population remains unclear. Here, we propose hypergeometric distribution-based method named Cov2Coinfect with ability decode composition from 50,809...
Impaired autophagy has been implicated in the pathogenesis of nonalcoholic fatty liver disease.Catalpol (CAT), a bioactive compound from Rehmannia (Di Huang) glutinosa, is known to ameliorate insulin resistance and histological NAFLD spectrum obese mice.Here, we investigated effects CAT on hepatic steatosis ob/ob high-fat diet-induced mice, as well hepatocytes.In reduced weight, triglyceride cholesterol content, lipogenic enzyme levels increased acid oxidase levels.In addition,...
The human multidrug transporter P-glycoprotein (P-gp) is physiologically essential and of key relevance to biomedicine. Recent structural studies have shed light on the mode inhibition third-generation inhibitors for P-gp, but molecular mechanism by which these enter transmembrane sites remains poorly understood. In this study, we utilized all-atom dynamics (MD) simulations characterize P-gp under a potent inhibitor, tariquidar, bound condition, as well atomic-level binding pathways in an...
The expansion of cold chain logistics necessitates a substantial fleet fuel-refrigerated trucks, which presents environmental challenges. Electric vehicles (EVs) offer an environmentally friendly solution for low-carbon development despite the issue range anxiety. Diverging from conventional two-echelon distribution structure, this paper explores alternative recharging strategies and introduces innovative scheme: employing fuel in suburban areas EVs urban central zones. presented model...
Human P-glycoprotein (hP-gp) is an ATP-binding cassette (ABC) exporter that actively extrudes a wide range of xenobiotics from the cell, thus limiting drug delivery and contributing to multidrug resistance (MDR) in cancers. Recent structural studies have provided insights into how hP-gp binds diverse compounds, but they are translocated through membrane remains poorly understood at atomic level. In this work, we used steered molecular dynamics (SMD) simulations investigate mechanism expels...
Porcine transmissible enteritis virus (TGEV) is a fatal pathogen affecting newborn piglets, presenting significant challenge to global intensive pig farming biosecurity due its ongoing mutation. There still lack of effective vaccines combat this virus, Vaccination has long been considered the most way overcome infectious diseases, however, traditional cannot be brought market quickly enough deal with rapid mutations and emerging viruses. Therefore, study addresses gap by using...
Abstract Background Both triglyceride glucose-body mass index (TyG-BMI) and non-alcoholic fatty liver disease (NAFLD) are linked to insulin resistance (IR). Prospective studies linking TyG-BMI NAFLD have been limited by short follow-up. This study investigated the longitudinal association between occurrence in non-obese Chinese individuals. Methods determined at baseline incidence of follow-up performed a post hoc analysis prospective cohort that involved assessing risk residents from...
Stress aging of myocardial cells participates in the mechanism fibrosis (MF). Previous studies have shown that hydrogen sulfide (H2S) can improve MF, however specific internal remains still unclear. Therefore, this study aims to explore whether H2S cell induced by high glucose and diabetic rats activating autophagy through SIRT6/AMPK. We observed HG (high glucose, 33 mM) down-regulation endogenous H2S-producing enzyme CSE protein expression, increased senescence, autophagy-related proteins...
Abstract Newcastle disease virus (NDV) infection causes severe inflammation and is a highly contagious in poultry. Virulent NDV strains (GM) induce large quantities of interleukin-1β (IL-1β), which the central mediator inflammatory reaction. Excessive expression IL-1β exacerbates damage. Therefore, exploring mechanisms underlying NDV-induced can aid further understanding pathogenesis disease. Here, we showed that anti-IL-1β neutralizing antibody treatment decreased body temperature mortality...