A5061718649- Spectroscopy and Chemometric Analyses
- AI in cancer detection
- Bladder and Urothelial Cancer Treatments
- Colorectal Cancer Screening and Detection
- Cervical Cancer and HPV Research
- Lung Cancer Treatments and Mutations
- Clinical Nutrition and Gastroenterology
- Meat and Animal Product Quality
- Ion Channels and Receptors
- Genetics, Aging, and Longevity in Model Organisms
- Glaucoma and retinal disorders
- Medical Imaging and Pathology Studies
- Radiology practices and education
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Nutrition and Health in Aging
- Tumors and Oncological Cases
- Immunotherapy and Immune Responses
- Erythropoietin and Anemia Treatment
- Urinary and Genital Oncology Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Global Cancer Incidence and Screening
- Enhanced Recovery After Surgery
- Pharmacological Effects and Toxicity Studies
- Healthcare and Venom Research
Southwest Medical University
2024-2025
Cleveland Clinic
2014-2024
Union Hospital
2024
Jilin University
2024
University of Pittsburgh Medical Center
2015-2023
Yangzhou University
2021-2023
Nanyang Institute of Technology
2021
UPMC Presbyterian
2021
Shadyside Hospital
2015-2021
University of Science and Technology of China
2020
Loss of mitochondrial membrane integrity and release apoptogenic factors are a key step in the signaling cascade leading to neuronal cell death various neurological disorders, including ischemic injury. Emerging evidence has suggested that intramitochondrial protein apoptosis-inducing factor (AIF) translocates nucleus promotes caspase-independent induced by glutamate toxicity, oxidative stress, hypoxia, or ischemia. However, mechanism which AIF is released from mitochondria after injury not...
Neuronal replacement has recently gained attention as a potential therapeutic target under ischemic conditions. However, the oligodendrogenic infrastructure is equally critical for restoration of brain function and also sensitive to injury. Erythropoietin (EPO) neuroprotective molecule that stimulates neuronal after neonatal hypoxia/ischemia (H/I) when delivered soon onset reperfusion. Because EPO can improve recovery neurological in absence tissue protection, we hypothesize may via...
Abstract Ferroptosis is closely linked to various cancers, including lung adenocarcinoma (LUAD); however, the factors involved in regulation of ferroptosis-related genes are not well established. In this study, we identified and characterized long noncoding RNAs (lncRNAs) LUAD. particular, a coexpression network mRNAs lncRNAs from The Cancer Genome Atlas (TCGA) was constructed. Univariate multivariate Cox proportional hazards analyses were performed establish prognostic lncRNA signature...
BACKGROUND Whole‐slide imaging in cytology is limited when glass slides are digitized without z‐stacks for focusing. Different vendors have started to provide z‐stacking solutions overcome this limitation. The Panoptiq system allows users create digital files combining low‐magnification panoramic images with regions of interest (ROIs) that imaged high‐magnification z‐stacks. aim study was compare such conventional whole‐slide and the tasks screening interpretation cytopathology. METHODS...
Abstract Background Previous cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large-scale, sufficiently powered study is therefore warranted to ascertain effects guideline implementation on patient-centered outcomes. Methods We conducted a multicenter, cluster-randomized, parallel-controlled trial intensive care units (ICUs) across China. developed...
The selection of a spectrophotometer for the measurement constituents agricultural materials with acceptable accuracy and cost effectiveness requires comparative study performance different spectrophotometers. Four commercially available spectrophotometers were evaluated, based on measurements performed three materials. These spectrophotometers, differing mainly in wavelength range principles, comprised diode array (DA) 300–1700 nm, combination scanning monochromator (DASM) 350–2500 Fourier...
Nicotinamide phosphoribosyltransferase (NAMPT) has been implicated in neuroprotection against ischemic brain injury, but the mechanism underlying its protective effect remains largely unknown. To further examine of NAMPT stroke and potential action, we generated a novel neuron-specific transgenic mouse line. Transgenic mice wild-type littermates were subjected to transient occlusion middle cerebral artery (MCAO) for 60 minutes. Neuron-specific overexpression significantly reduced infarct...
The human multidrug transporter P-glycoprotein (P-gp) is physiologically essential and of key relevance to biomedicine. Recent structural studies have shed light on the mode inhibition third-generation inhibitors for P-gp, but molecular mechanism by which these enter transmembrane sites remains poorly understood. In this study, we utilized all-atom dynamics (MD) simulations characterize P-gp under a potent inhibitor, tariquidar, bound condition, as well atomic-level binding pathways in an...
Long context large language models (LLMs) pose significant challenges for efficient serving due to the memory footprint and high access overhead of KV cache. Retrieval-based cache reduction methods can mitigate these challenges, typically by offloading complete CPU retrieving necessary tokens on demand during inference. However, still suffer from unsatisfactory accuracy degradation extra retrieval overhead. To address limitations, this paper proposes A$^2$ATS, a novel retrieval-based method....
Human P-glycoprotein (hP-gp) is an ATP-binding cassette (ABC) exporter that actively extrudes a wide range of xenobiotics from the cell, thus limiting drug delivery and contributing to multidrug resistance (MDR) in cancers. Recent structural studies have provided insights into how hP-gp binds diverse compounds, but they are translocated through membrane remains poorly understood at atomic level. In this work, we used steered molecular dynamics (SMD) simulations investigate mechanism expels...
Abstract Background Accurate identification of isolates belonging to genus Enterococcus, Streptococcus, coagulase-negative Staphylococcus, and Lactococcus at the species level is necessary provide a better understanding their pathogenic potential, aid in making clinical decisions, conduct epidemiologic investigations,especially when large blind samples must be analyzed. It useful simultaneously identify different genera using single primer pair. Methods We developed pair based on tuf gene...
1,4,5-trisphosphate (IP(3))-dependent Ca(2+) signaling regulates gonad function, fertility, and rhythmic posterior body wall muscle contraction (pBoc) required for defecation in Caenorhabditis elegans. Store-operated entry (SOCE) is activated during endoplasmic reticulum (ER) store depletion believed to be an essential ubiquitous component of pathways. SOCE thought function refill stores modulate signals. Recently, stromal interaction molecule 1 (STIM1) was identified as a putative ER sensor...