A5100392826- Pancreatitis Pathology and Treatment
- Clinical Nutrition and Gastroenterology
- Respiratory Support and Mechanisms
- Phagocytosis and Immune Regulation
- Heart Failure Treatment and Management
- Neonatal Respiratory Health Research
- Esophageal and GI Pathology
- Enhanced Recovery After Surgery
- Cancer-related molecular mechanisms research
- Nutrition and Health in Aging
- Pancreatic and Hepatic Oncology Research
- Nutritional Studies and Diet
- Immune Response and Inflammation
- Protein Kinase Regulation and GTPase Signaling
- Intracerebral and Subarachnoid Hemorrhage Research
- Intestinal Malrotation and Obstruction Disorders
- Signaling Pathways in Disease
- Abdominal Surgery and Complications
- Cytokine Signaling Pathways and Interactions
- Heme Oxygenase-1 and Carbon Monoxide
- Maternal and fetal healthcare
- Microbial Inactivation Methods
- Cardiovascular and Diving-Related Complications
- Berberine and alkaloids research
- Kruppel-like factors research
China Medical University
2011-2024
Liaoning Cancer Hospital & Institute
2020-2023
University of Minnesota
2016-2018
Air Force Institute of Aviation Medicine Affiliated Hospital
2011
Wuxi No.2 People's Hospital
2006
CAE (Canada)
2005
Abstract Background Previous cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large-scale, sufficiently powered study is therefore warranted to ascertain effects guideline implementation on patient-centered outcomes. Methods We conducted a multicenter, cluster-randomized, parallel-controlled trial intensive care units (ICUs) across China. developed...
This study was designed to evaluate the effects of total enteral nutrition and parenteral in prevention pancreatic necrotic infection severe acute pancreatitis.One hundred seven patients were enrolled between 2003 2007. In first week hospitalization, they randomized feeding by either (54 patients) or (53 patients). All concomitantly administered with sufficient prophylactic antibiotics. Computed tomographic scan C-reactive protein level indicated a similar clinical severity both...
Background Ossabaw pigs are unique miniature swine with genetic predisposition to develop metabolic syndrome and coronary atherosclerosis after extended periods receiving atherogenic diets. We have hypothesized that transgenic expressing chimp PCSK9 (proprotein convertase subtilisin‐like/kexin type 9) containing the D374Y gain of function would familial hypercholesterolemia artery plaques more rapidly than Landrace same transgene. Methods Results gain‐of‐function founders were generated by...
The present retrospective study aimed to analyze the optimal time initiate enteral nutrition (EN) in patients with severe acute pancreatitis at a single Chinese institution (China Medical University Hospital).A total of 1196 were admitted intensive care unit between November 2003 and June 2013; 1092 selected divided into early delayed EN groups, according their initial timing EN.Five hundred sixty-six administered EN, 526 EN. Both groups had similar severity pancreatic necrosis, but organ...
There is a lack of large-scale epidemiological data on the clinical practice enteral nutrition (EN) feeding in China. This study aimed to provide such Chinese hospitals and investigate factors associated with EN delivery.This cross-sectional was launched 118 intensive care units (ICUs) 116 mainland conducted April 26, 2017. At 00:00 all patients these ICUs were included. Demographic variables 25 obtained. The dates hospitalization, ICU admission initiation reviewed. outcome status 28 days...
Constitutively activated signal transducer and activator of transcription 3 (STAT3) has been linked to cisplatin (DDP)-resistance in a wide range cancers. Recent work indicated that Rho GTPase-activating protein 6 (ARHGAP6) promotes cell cycle arrest apoptosis cervical breast However, the role ARHGAP6 lung adenocarcinoma DDP-resistance remains unknown.Bioinformatic analysis, quantitative RT-PCR IHC staining were used explore expression patterns The Cancer Genome Atlas (TCGA) dataset patient...
Abstract Objective We aimed to investigate the association of macrophage inflammatory protein (MIP)‐1α (CCL3) expression with severity acute pancreatitis (AP). Methods The patients AP were selected and divided into mild (MAP), moderately severe (MSAP), (SAP) groups according AP. pancreatic acinar cell line Ar42 j was treated cerulein induce in vitro model. tumor necrosis factor‐α (TNF‐α) interleukin‐6 (IL‐6) activation c‐Jun N‐terminal kinase (JNK)/p38 mitogen‐activated (MAPK) signaling...
Abstract Severe acute pancreatitis (SAP) is a condition associated with high rates of mortality and lengthy hospital stays. In the current study, SAP mouse models were established in BALB/c wild‐type P21‐activated kinase 1 (PAK1) knockdown mice objective determining expression microRNA‐542‐5p (miR‐542‐5p) subsequent elucidation mechanism by which it influences lung injury (ALI) mediating mitogen‐activated protein (MAPK) signaling binding to PAK1. The targeting relationship between miR‐542‐5p...
Summary Total parenteral nutrition (TPN) results in atrophy of the pancreas, while cholecystokinin (CCK) can significantly stimulate exocrine pancreas rodents. This study was designed to examine whether CCK may improve rats on TPN treatment. Forty‐eight Sprague–Dawley were divided into orally fed and groups infused with at a dose 5 μg/kg/h or CCK‐receptor antagonist devazepide 200 for 10 days. Infusion caused hypercholecystokininemia (hyperCCKemia) decreased resulting from TPN. The...
To investigate the pathogenesis of early biotrauma in ventilator-induced lung injury (VILI).Twenty-four 8-week-old male specific-pathogen-free Sprague-Dawley (SD) rats weighing 250-300 g were randomly divided into sham group (S group), conventional mechanical ventilation (L group) and high tidal volume (VT) (H with 8 each group. All received tracheostomy after anesthesia. Rats S no but breathe room air spontaneously. other parameters ventilator same both groups, fraction oxygen was set to...
To analyze the correlation between fluid equilibrium and oxygen index in patients at early stage (within 2 weeks) of severe acute pancreatitis (SAP), to discuss effects after resuscitation on prognosis.A clinical study was conducted. Ninety-seven with SAP admitted into Shengjing Hospital China Medical University directly or transferred intensive care unit (ICU) 24 hours admission March 2011 October 2013 were studied. Finally, 65 enrolled statistical analysis, those termination treatment...
Objective To study the effects of different positive end-expiratory pressure (PEEP) levels on heart function patients undergoing mechanical ventilation (MV) with echocardiography. Methods Thirty-six critical respiratory failure MVwere divided into two groups according to cardiac index (CI). The left was measured echocardiography at PEEP (0, 4, 7, 10, 14 cm H2O, 1cm H2O = 0. 098 kPa). Results In normal group (CI≥2. 0 L · min-1 m-2, n=17), an increase in had no significant ventricular systolic...