A5105517567- Systemic Lupus Erythematosus Research
- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Biosensors and Analytical Detection
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Salivary Gland Disorders and Functions
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Bone and Joint Diseases
- Cytomegalovirus and herpesvirus research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Regulation of Appetite and Obesity
- Autophagy in Disease and Therapy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal Diseases and Glomerulopathies
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Immune cells in cancer
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Nanjing Drum Tower Hospital
2014-2024
Nantong University
2014-2024
Affiliated Hospital of Nantong University
2014-2024
Jilin University
2024
Health Commission of Jilin Province
2024
Union Hospital
2024
Union Hospital
2024
Jiangnan University
2024
A dual intramolecular electrochemiluminescence resonance energy transfer process is proposed with triple-component Pdots to enhance ECL emission, which greatly improves the efficiency and can be used for sensitive specific visual quantification of different targets.
The controllable growth of metal nanoparticles on nanomaterials is becoming a useful strategy for developing nanocomposites with designated performance. Here, DNA-controlled Pt graphene oxide (GO–PtNPs) to regulate the nanozyme activity and triplex-hybridization chain reaction (tHCR) triggering assembly DNA probes amplify target-induced catalytic signal were designed. tHCR one linear two hairpin could be specially triggered by trigger form long double-stranded structure in presence target...
We recently found that adipose afferent reflex (AAR) induced by chemical stimulation of white tissue (WAT) increased sympathetic outflow and blood pressure in normal rats. The study was designed to test the hypothesis AAR contributes activation obesity hypertension. Male rats were fed with a control diet (12% kcal as fat) or high-fat (42% for 12 weeks induce Stimulation WAT capsaicin renal nerve activity mean arterial pressure. Both enhanced hypertension (OH) compared nonhypertension (ON) ON...
Rationale: Although mesenchymal stem cell (MSC) transplantation has been proved to be an effective therapeutic approach treat experimental Sjögren's syndrome (SS), the detailed underlying mechanisms remains unknown. IL-27 diverse influences on regulation of T differentiation and was involved in SS through modulating immune response. Here we aimed explore whether IL-27-mediated cells responsible for beneficial effects MSC SS. Methods: The SS-like symptoms were evaluated deficient recombinant...
Objective Mesenchymal stem cells (MSCs) derived from patients with systemic lupus erythematosus (SLE) exhibit enhanced senescence. Cellular senescence has been reported to be induced by several inflammatory cytokines, including interferon‐α (IFNα) and IFNγ, that are involved in the pathogenesis of SLE. We undertook this study investigate whether environment SLE could affect MSC Methods was measured staining senescence‐associated β‐galactosidase expression cell cycle inhibitors p53 p21....
Lipocalin-2 (LCN2) is an indicator of the severity lupus nephritis (LN) and plays a pivotal role in immune responses, but it not known if its effect on LN pathogenesis derives from regulating imbalance T lymphocyte subsets.The expression LCN2 cells kidneys was assessed renal biopsies patients with LN. We investigated relationship between levels development systemic illness by injecting anti-LCN2 antibodies into MRL/lpr mice analyzing pristane-treated LCN2-/- mice.LCN2 highly expressed CD4+...
The therapeutic application of mesenchymal stem cells (MSCs) has good potential as a treatment strategy for systemic lupus erythematosus (SLE), but traditional MSC therapy still limitations in effectively modulating immune cells. Herein, we present promising based on dexamethasone liposome-integrated MSCs (Dexlip-MSCs) treating SLE via multiple immunomodulatory pathways. This prolonged the circulation time liposomes vivo, restrained CD4+T-cell proliferation, and inhibited release...
Injection of leptin into white adipose tissue (WAT) increases sympathetic outflow. The present study was designed to determine the effects capsaicin and other chemicals in WAT on outflow blood pressure roles afferents hypothalamic paraventricular nucleus (PVN) afferent reflex (AAR). AAR induced by injection capsaicin, bradykinin, adenosine, adenosine triphosphate (ATP), or inguinal (iWAT) retroperitoneal (rWAT) anesthetized rats. iWAT increased renal nerve activity (RSNA) mean arterial (MAP)...
Autoreactive T cells play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE). TGF-β type I receptor (TGFβRI) is pivotal determining cell activation. Here, we showed that TGFβRI expression naïve CD4+ was decreased SLE patients, especially those with high disease activity. Moreover, IL-6 found to downregulate through JAK/STAT3 pathway patients. In vitro, JAK inhibitor tofacitinib inhibited activating by upregulating dose-dependent manner. MRL/lpr mice, treatment...
Background The enhanced cardiac sympathetic afferent reflex (CSAR) is involved in the activation that contributes to pathogenesis and progression of hypertension. Activation AT1 receptors by angiotension (Ang) II paraventricular nucleus (PVN) augments CSAR outflow present study designed determine whether Ang-(1-7) PVN plays similar roles as Ang interaction between on renovascular Methodology/Principal Findings two-kidney, one-clip (2K1C) method was used induce evaluated renal nerve activity...
Blood pressure (BP) control in China is generally poor. It assumed that an important cause of this unsatisfactory situation the present standard care provided by primary physicians. One thousand community health centers (CHCs) were selected across based on geographical location, previous cooperative experience, and acceptance invitation to implement a standardized protocol community-based BP management. Baseline information for each hypertensive patient under these CHCs was collected,...
Background The presence of food-specific IgG antibodies in human serum may be useful for diagnosis adverse food reactions. However, the clinical utility tesing such remains very controversial. aim this study was to evaluate levels and population distribution IgGs their association with chronic symptoms a large-scale Chinese population. Methodology/Principal Findings A total 21305 adult participants from different regions China had 14 type that were measured by enzyme-linked immunosorbent...
Recently, clinical studies have suggested that transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) were able to alleviate symptoms refractory systemic lupus erythematosus (SLE). Although dental tissue derived MSCs, including pulp (DPSCs) and periodontal ligament cell (PDLSCs), been reported possess immunomodulatory functions, whether they can ameliorate SLE as UC-MSCs remains be elucidated.We assessed the abilities DPSCs PDLSCs treat SLE, transferred intravenously 28-week old...