A5052200922- Systemic Lupus Erythematosus Research
- Land Use and Ecosystem Services
- Mesenchymal stem cell research
- Conservation, Biodiversity, and Resource Management
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- T-cell and B-cell Immunology
- Economic and Environmental Valuation
- Hydrocarbon exploration and reservoir analysis
- IoT and Edge/Fog Computing
- Salivary Gland Disorders and Functions
- Enhanced Oil Recovery Techniques
- Wildlife-Road Interactions and Conservation
- MicroRNA in disease regulation
- Phase Equilibria and Thermodynamics
- Zeolite Catalysis and Synthesis
- Liver Diseases and Immunity
- interferon and immune responses
- Bone and Joint Diseases
- NMR spectroscopy and applications
- Atherosclerosis and Cardiovascular Diseases
- Urban Transport and Accessibility
- Cholesterol and Lipid Metabolism
- Immune cells in cancer
Southwest Forestry University
2020-2025
Nanjing University of Chinese Medicine
2023-2024
Huazhong Agricultural University
2023-2024
Chongqing University
2024
Jiangsu Province Hospital
2024
Lanzhou University
2024
Nanjing Drum Tower Hospital
2015-2023
Inner Mongolia University of Technology
2023
Shanxi Medical University
2023
Henan Normal University
2022
Abstract Allogeneic mesenchymal stem cells (MSCs) exhibit immunoregulatory function in human autoimmune diseases such as systemic lupus erythematosus (SLE), but the underlying mechanisms remain incompletely understood. Here we show that number of peripheral tolerogenic CD1c + dendritic (DCs) and levels serum FLT3L are significantly decreased SLE patients especially with nephritis, compared to healthy controls. Transplantation allogeneic umbilical cord-derived MSCs (UC-MSCs) up-regulates...
Landscape pattern, ecosystem service value (ESV), and human well-being are closely related. Determining the link between three is significant to realization of regional sustainable development. However, relationship complex vulnerable multiple factors, many which remain unknown. This study used remote sensing imagery Xishuangbanna map land-use in 1996, 2003, 2010, 2016 landscape metrics quantify pattern changes. research evaluated changes ESV using benefit transfer method evaluation index...
Defective clearance of apoptotic cells (ACs) has been suggested to be involved in the pathogenesis systemic lupus erythematosus (SLE). Mesenchymal stem (MSCs) exhibit promising therapeutic effects on SLE, but whether MSCs phagocytose ACs and contributes underlying mechanism treatment SLE remain unknown.Human umbilical cord (UC) were co-cultured with ACs, engulfment by was either detected flow cytometry or observed under confocal laser scanning microscope. Peripheral blood mononuclear (PBMCs)...
COVID-19, caused by the SARS-CoV-2 virus, is a respiratory infectious disease. While most patients recover after treatment, there growing evidence that COVID-19 may result in cognitive impairment. Recent studies reveal some individuals experience deficits, such as diminished memory and attention, well sleep disturbances, suggesting could have long-term effects on function. Research indicates contribute to decline damaging crucial brain regions, including hippocampus anterior cingulate...
Disturbed lipid metabolism was observed in systemic lupus erythematosus (SLE) patients. This study aimed to evaluate the relationships between dyslipidemia and visceral organ involvement, disease severity, inflammatory factors, drug intake SLE patients.Inpatients with (n = 105) healthy controls (HC) 75) were recruited this study. Clinical laboratory data collected from patient records. The concentrations of tumor necrosis factor receptors superfamily member1A (TNFRSF1A), member1B (TNFRSF1B)...
Abstract T follicular helper (Tfh) cells provide help for antigen-specific B cells. We have previously shown that Tfh cell frequency was increased and associated with auto-antibodies in patients rheumatoid arthritis (RA), suggesting a possible involvement of its pathogenesis. Mesenchymal stem (MSCs) represent promising alternative therapy RA by modulating activation proliferation. However, it remains unknown whether MSCs immunoregulation on In this paper, we demonstrated allogeneic could...
Mesenchymal stem cells (MSCs) have been demonstrated to be effective in treating autoimmune diseases including Sjögren's syndrome (SS). We aim compare the effects of MSC transplantation (MSCT) and role serum interleukin-12 (IL-12) SS. IL-12 levels were measured by ELISA. mRNA transcripts dendritic (DCs) determined RT-PCR. After co-culturing with MSCs, mouse human DCs detected. Non-obese diabetic (NOD) mice received MSCT, recombinant IL-12, or anti-IL-12 mAb treatment, respectively. Then,...
Lipocalin-2 (LCN2) is an indicator of the severity lupus nephritis (LN) and plays a pivotal role in immune responses, but it not known if its effect on LN pathogenesis derives from regulating imbalance T lymphocyte subsets.The expression LCN2 cells kidneys was assessed renal biopsies patients with LN. We investigated relationship between levels development systemic illness by injecting anti-LCN2 antibodies into MRL/lpr mice analyzing pristane-treated LCN2-/- mice.LCN2 highly expressed CD4+...
Integrating the theory of planned behavior (TPB) and norm activation model (NAM), this study investigated formation mechanism university students’ willingness-to-pay (WTP) for carbon offsets under climate change. Through a survey 2728 students across 28 universities in Yunnan Province, China, we developed an extended TPB-NAM framework incorporating offset cognition (COC), change hazard perception (CCHP), awareness (CCA). Key findings revealed following. (1) The integrated explained 74.8% WTP...
The aberrant generation or activation of T follicular helper (Tfh) cells contributes to the pathogenesis systemic lupus erythematosus (SLE), yet little is known about how these are regulated. In this study, we demonstrated that frequency Tfh was increased in lupus-prone B6.MRL-Faslpr (B6.lpr) mice and positively correlated plasma cell proportions serum total IgG as well anti-dsDNA antibody levels. Transplantation mesenchymal stem derived from Wharton's jelly human umbilical cords (hUC-MSCs)...
Mesenchymal stem cells (MSCs) play an anti-inflammatory role by secreting certain bioactive molecules to exert their therapeutic effects for disease treatment. However, the underlying mechanism of MSCs in chronic autoimmune liver diseases—primary biliary cholangitis (PBC), example—remains be elucidated. Human umbilical cord–derived (UC-MSCs) were injected intravenously into 2-octynoic acid coupled bovine serum albumin (2OA-BSA)-induced mice. Serum levels biomarkers and autoantibodies,...
Aberrant autophagy played an important role in the pathogenesis of autoimmune diseases, especially systemic lupus erythematosus (SLE). In this study, we showed that T cells from SLE patients had higher autophagic activity than healthy controls. A correlation between and apoptotic rate was observed activated cells. Moreover, activation with rapamycin increased cell apoptosis, whereas inhibition 3-MA decreased apoptosis. Umbilical cord-derived mesenchymal stem (UC-MSCs) could inhibit...
Podocyte injury plays a pathogenic role in the development of lupus nephritis (LN). Mesenchymal stem cells (MSCs) have shown promising therapeutic potential for LN. However, whether MSCs can prevent podocyte LN remains unknown. Human umbilical cord-derived (UC-MSCs) were infused into lupus-prone B6.MRL-Faslpr (B6.lpr) mice to investigate influences UC-MSCs on Podocytes and macrophages co-cultured with vitro study mechanism by which UC-MSC protect podocytes. We further explored effects...
Autoreactive T cells play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE). TGF-β type I receptor (TGFβRI) is pivotal determining cell activation. Here, we showed that TGFβRI expression naïve CD4+ was decreased SLE patients, especially those with high disease activity. Moreover, IL-6 found to downregulate through JAK/STAT3 pathway patients. In vitro, JAK inhibitor tofacitinib inhibited activating by upregulating dose-dependent manner. MRL/lpr mice, treatment...
The high-quality development in the Yunnan–Guizhou region (YGR) is a significant support for of China. It will help shape new pattern regional coordinated development. Referring to Beautiful China and United Nations Sustainable Development Goals (SDGs) evaluation indexes, we built an index system that puts at its heart. This includes resource load, economic development, ecological environment protection, social progress. Taking 25 prefecture-level cities YGR as study subjects, authors used...