A5101448454- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Hepatitis C virus research
- Retinoids in leukemia and cellular processes
- Gut microbiota and health
- Liver physiology and pathology
- Extracellular vesicles in disease
- Ginseng Biological Effects and Applications
- Rheumatoid Arthritis Research and Therapies
- Galectins and Cancer Biology
- Click Chemistry and Applications
- RNA regulation and disease
- Atomic and Molecular Physics
- Biotin and Related Studies
- Transplantation: Methods and Outcomes
- Nanowire Synthesis and Applications
- Histiocytic Disorders and Treatments
- Gas Sensing Nanomaterials and Sensors
- Cell death mechanisms and regulation
- Autoimmune and Inflammatory Disorders Research
- Advanced Frequency and Time Standards
- Scientific Measurement and Uncertainty Evaluation
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
Soochow University
2025
Shanghai University of Traditional Chinese Medicine
2022-2024
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2021-2024
Affiliated Hospital of Guangdong Medical College Hospital
2024
Fudan University
2006-2022
Sun Yat-sen University
2022
Institute of Modern Physics
2022
Delft University of Technology
2022
Eighth Affiliated Hospital of Sun Yat-sen University
2022
Huashan Hospital
2019
Abstract Rheumatoid arthritis (RA) is an autoimmune disease. Early studies hold opinion that gut microbiota environmentally acquired and associated with RA susceptibility. However, accumulating evidence demonstrates genetics also shape the microbiota. It known some strains of inbred laboratory mice are highly susceptible to collagen-induced (CIA), while others resistant CIA. Here, we show transplantation fecal CIA-resistant C57BL/6J CIA-susceptible DBA/1J confer CIA resistance in mice....
Growth inhibition assays indicated that the IC50 values for methotrexate (MTX) and 5-fluorodeoxyuridine (FdUrd) in HS-18, a liposarcoma cell line lacking retinoblastoma protein (pRB), SaOS-2, an osteosarcoma with truncated nonfunctional pRB, were 10- to 12-fold 4- 11-fold higher, respectively, than HT-1080 (fibrosarcoma) line, which has wild-type pRB. These Rb-/- lines exhibited 2- 4-fold increase both dihydrofolate reductase (DHFR) thymidylate synthase (TS) enzyme activities as well 3- mRNA...
Rheumatoid arthritis (RA) is an autoimmune disease. Fibroblast-like synoviocytes (FLS) serve a major role in synovial hyperplasia and inflammation RA. (5R)-5-hydroxytriptolide (LLDT-8), novel triptolide derivative, shows promising therapeutic effects for RA now phase II clinical trials China. However, the underlying mechanism of LLDT-8 still not fully understood. Here, we found that inhibited proliferation invasion FLS, as well production cytokines. Microarray data demonstrated upregulated...
The growth and integration of position-controlled, morphology-programmable silicon nanowires (SiNWs), directly upon low-cost polymer substrates instead postgrowth transferring, is attractive for developing advanced flexible sensors logics. In this work, a low temperature SiNWs at only 200 °C has been demonstrated, the first time, polyimide (PI) films, via planar solid-liquid-solid (IPSLS) mechanism. with diameter ∼146 nm can be grown into precise locations on PI as orderly array preferred...
Solid-state metal batteries (SSMBs), with their high theoretical energy density and inherent safety advantages, are considered to be the ultimate choice for next-generation storage systems. Extensive experimental theoretical...
Mesenchymal stem cells (MSCs) play an anti-inflammatory role by secreting certain bioactive molecules to exert their therapeutic effects for disease treatment. However, the underlying mechanism of MSCs in chronic autoimmune liver diseases—primary biliary cholangitis (PBC), example—remains be elucidated. Human umbilical cord–derived (UC-MSCs) were injected intravenously into 2-octynoic acid coupled bovine serum albumin (2OA-BSA)-induced mice. Serum levels biomarkers and autoantibodies,...
Background Alterations in the expression of genes that control cell cycle may be critical importance determining sensitivity cells and tumors to drugs (chemosensitivity) radiation. Mutations deletions p53 tumor suppressor gene lines are associated with resistance a variety DNA-damaging agents. The effects alterations cyclin their products on drug action have not been studied. One these genes, D1, is expressed early G 1 phase, its protein product, together cyclin-dependent kinases CDK4 CDK6,...
Abstract The 4s 2 4p P 3/2 – 1/2 magnetic dipole transition in Ga-like ions is interested developing of high precise highly charged ion clock (Yu and Sahoo 2019 Phys. Rev. A 99 022513). In this work, we present direct observations the Mo 11+ Ru 13+ at an electron beam trap. Internal external calibration methods are used for determining wavelength lines, respectively. Both measurements reach precision levels a few ppm. Compared with available values, current results significantly improve...
Extracellular vesicles (EVs) are a promising new therapeutic platform. However, the low cargo-loading efficiency limits their clinical translation. In this study, we developed high-yield EV device and explored its ability to encapsulate gene editing proteins. A series of fusion protein-based systems were constructed cargo loading efficiencies compared by NanoGlo luciferase assay. myristoylated (Myr) peptide tag cloned from N-terminal region charged multivesicular body protein 6 (CHMP6),...
In this work, we report a spectroscopy measurement of Ru21+ to Ru24+ ions in the optical region using low energy electron beam ion trap. Twelve lines were observed. The multiconfiguration Dirac–Hartree–Fock and relativistic configuration interaction methods used calculate atomic level energies transition rates. With assistance theoretical results, eleven magnetic dipole identified. experimental results provide new reference data for further investigations complex ions.
Multicentric reticulohistiocytosis (MRH) is a rare disease with poorly defined therapeutic strategies. Here, we report the case of patient eosinophilic gastroenteritis who developed MRH after 5 years. The presented disabling and rapidly progressive polyarthralgia, gastroenteritis, resistance to first-line therapies. However, there was marked improvement in arthritis symptoms following treatment tofacitinib. This presentation provides useful perspective for management complex scenarios involving MRH.
Abstract Biliary epithelial cells (BECs) can secrete bile and the epithelial‐to‐mesenchymal transition (EMT) of BECs cause fibrosis or damage interlobular ducts, leading to chronic cholangiopathies, such as primary biliary cholangitis (PBC). Transforming growth factor‐β1 (TGF‐β1) is a potent inducer EMT while curcumin, diarylheptanoid, inhibit hepatocytes in many liver diseases. However, protection underlying mechanisms curcumin against have not been clarified. Herein, we show that treatment...
<title>Abstract</title> <bold>Background: </bold>Iatrogenic coronary artery dissection is a potential complication during percutaneous bioresorbable vascular scaffolds placement. We report that significant occurred post-expansion of the left rotatory branch to attach it wall. Additional resorbable stents successfully covered without blood flow restriction. <bold>Casereport: </bold>The patient was 49-year-old male with strong implantable concept and diagnosed stable angina pectoris type 2...
<h3>Background</h3> Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterized by slowly progressive non-suppurative cholangitis with immune mediated destruction of intrahepatic bile ducts. Previous studies have shown beneficial effects mesenchymal stem cells (MSCs) transplantation in many autoimmune diseases. However, few focused on the MSCs PBC. <h3>Objectives</h3> In our study, we investigated therapeutic effect umbilical cord-derived (UC-MSCs) well-defined mouse model...