A5070984049- Protein Degradation and Inhibitors
- Catalytic Processes in Materials Science
- Zeolite Catalysis and Synthesis
- Mesoporous Materials and Catalysis
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Catalysis and Oxidation Reactions
- Alcohol Consumption and Health Effects
- Histone Deacetylase Inhibitors Research
- Multiple Myeloma Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
- Supercapacitor Materials and Fabrication
- Herbal Medicine Research Studies
- Oxidative Organic Chemistry Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Nigella sativa pharmacological applications
- Viral Infections and Immunology Research
- Polyoxometalates: Synthesis and Applications
- Adrenal Hormones and Disorders
- Dendrimers and Hyperbranched Polymers
- Chemotherapy-induced organ toxicity mitigation
- Radioactive element chemistry and processing
- Immune cells in cancer
Southern University of Science and Technology
2021-2024
Hong Kong Baptist University
2021-2024
Hangzhou Normal University
2022
Jilin University
2006-2020
Jilin Agricultural University
2020
Chinese Academy of Sciences
2011
Changchun Institute of Applied Chemistry
2011
Objectives Rheumatoid arthritis (RA) is an autoimmune disease characterised by aggressive fibroblast-like synoviocytes (FLSs). Very few RA patients-derived FLSs (RA-FLSs)-specific surface signatures have been identified, and there currently no approved targeted therapy for RA-FLSs. This study aimed to screen therapeutic aptamers with cell-targeting cytotoxic properties against RA-FLSs uncover the molecular targets mechanism of action screened aptamers. Methods We developed a cell-specific...
Abstract Rheumatoid arthritis (RA) is an autoimmune disease. Early studies hold opinion that gut microbiota environmentally acquired and associated with RA susceptibility. However, accumulating evidence demonstrates genetics also shape the microbiota. It known some strains of inbred laboratory mice are highly susceptible to collagen-induced (CIA), while others resistant CIA. Here, we show transplantation fecal CIA-resistant C57BL/6J CIA-susceptible DBA/1J confer CIA resistance in mice....
<p>Rheumatoid arthritis (RA) is a poly-articular systemic autoimmune disorder characterized by infiltration of immune cells, synovial hyperplasia and joint destruction. Macrophages (MΦs) can polarize into either pro-inflammatory M1 or anti-inflammatory M2 phenotype in response to different environmental signals. In RA, MΦs are prone the phenotype. Reprogramming has shown promise treating diseases, <i>e.g.</i>, chimeric antigen receptor-MΦ (CAR-M)-based adoptive...
This study investigated the hepatoprotective effects of Morchella esculenta fruit body (ME) and underlying mechanisms in mice with alcohol-induced acute liver injury. Systematic analysis revealed that ME contained 21 types fatty acid, 17 amino 12 mineral. Subsequently, a mouse model injury was established by oral administration alcohol for 14 days. Fourteen-day prevented increases alanine aminotransferase aspartate levels reduced activity acetaldehyde dehydrogenase blood serum tissue....
Excessive alcohol consumption causes liver injury-induced mortality. Here we systematically analyzed the structure of triterpenoids extracted from Antrodia cinnamomea mycelia (ACT) and investigated their protective effects against acute alcohol-induced injury in mice. Liquid chromatography-mass spectrometry liquid chromatography with tandem mass were performed to determine structures ACT constituents. Alcohol-induced was generated C57BL/6 mice by oral gavage 13 g/kg white spirit (a wine at...
Aronia melanocarpa (AM), which is rich in anthocyanins and procyanidins, has been reported to exert antioxidative anti-inflammatory effects. This study aimed systematically analyze the components of AM explore its effects on alcohol-induced chronic liver injury mice. A component analysis revealed 17 types fatty acids, amino 8 minerals, 3 nucleotides. Chronic was established mice via gradient alcohol feeding over a period 6 months, with test groups orally receiving last weeks. administration...
Rationale: Osteosarcoma (OS) is the most common bone malignancy. c-MET recognized as a therapeutic target. However, traditional inhibitors show compromised efficacy due to acquired resistance and side effects. PROTACs targeting have displayed improved antitumor by overcoming drug resistance, whereas safety concern caused lack of tumor-targeting ability still pending issue. AS1411 an aptamer that recognizes penetrates tumors nucleolin (NCL) overexpressed on surface tumor cells. Since NCL...
Abstract Monodisperse cyano‐functionalized porous polymeric beads were synthesized by seeded polymerization; these microparticles further used as support for zirconocene catalyst, which performed a solid homogeneous catalyst in ethylene polymerization. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Chem,
Aronia melanocarpa fruit (AM) strongly suppressed ankle swelling in rats with acute gout and reduced the levels of uric acid xanthine oxidase (XO) mice hyperuricemia. AM inflammatory cell count increased joint space, interleukin (IL)-1β, IL-10, monocyte chemoattractant protein-1 tumour necrosis factor-α serum gout. In hyperuricemia, significantly acid, blood urea nitrogen, creatinine. 8-day administration resulted enhancements glutathione peroxidase, superoxide dismutase catalase a reduction...
MDM2 is a negative regulator of tumor suppressor p53 and serves as therapeutic target for various cancers. Currently, there are no clinically available antitumor drugs modulating MDM2-p53 signaling because the existing inhibitors have limited efficacy excessive toxicity. PROTACs heterobifunctional molecules recruiting E3 ligases proteins interest (POIs) to induce proteasomal degradation POIs. PROTAC degraders provide better potency but still cannot address safety concern due lack...