A5101744035- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Multiple Myeloma Research and Treatments
- Cancer-related gene regulation
- Plant biochemistry and biosynthesis
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Metabolomics and Mass Spectrometry Studies
- Crystallization and Solubility Studies
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- PI3K/AKT/mTOR signaling in cancer
- Tryptophan and brain disorders
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- X-ray Diffraction in Crystallography
- Cancer Cells and Metastasis
Dalian Medical University
2018-2025
Shanghai University of Traditional Chinese Medicine
2025
Second Affiliated Hospital of Jilin University
2017-2024
Peking University
2023-2024
Zhejiang Chinese Medical University
2019-2024
Guangzhou Medical University
2024
Peking University People's Hospital
2023-2024
Wuhan University
2024
Beijing University of Chemical Technology
2024
Shantou University
2011-2024
Abstract SARS-CoV-2 is the pathogen responsible for COVID-19 pandemic. The papain-like cysteine protease (PLpro) has been implicated in playing important roles virus maturation, dysregulation of host inflammation, and antiviral immune responses. multiple functions PLpro render it a promising drug target. Therefore, we screened library approved drugs also examined available inhibitors against PLpro. Inhibitor GRL0617 showed vitro IC 50 2.1 μM an effective inhibition cell-based assays....
The PD-L1/PD-1 pathway blockade-mediated immune therapy has shown promising efficacy in the treatment of multiple cancers including melanoma. present study investigated effects flavonoid apigenin on PD-L1 expression and tumorigenesis melanoma.The influence flavonoids melanoma cell growth apoptosis was using proliferation flow cytometric analyses. differential IFN-γ-induced STAT1 activation were examined curcumin apigenin-treated cells immunoblotting or immunofluorescence assays. sensitivity...
// Shu-Yan Liu 1 and Peng-Sheng Zheng 1,2 Department of Reproductive Medicine, The First Affiliated Hospital the Medical College, Xi'an Jiaotong University, Xi'an, People's Republic China 2S ection Cancer Stem Cell Research, Key Laboratory Environment Genes Related to Diseases, Ministry Education China, Correspondence: Zheng, email: Keywords : aldehyde dehydrogenase, cancer stem cells, cervical cancer, self-renewal, chemoresistance Received November 5, 2013 Accepted 23, Published 25,...
ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As membrane-embedded receptor tyrosine kinase, cell surface levels are regulated dynamically by membrane physical properties. The present study aims to investigate the influence cholesterol contents on status cellular responses its kinase inhibitors. abundance was examined in cells using filipin staining. Cellular localizations were investigated...
// Juan Du 1,* , Shuyan Liu Jie He 1 Xi Ying Qu Wenqing Yan Jianling Fan Rong Li Hao Weijun Fu Chunyang Zhang Jing Yang 2 and Jian Hou Department of Hematology, The Myeloma Lymphoma Center, Changzheng Hospital, Second Military Medical University, Shanghai, China Lymphoma/Myeloma, Division Cancer Medicine Center for Immunology Research, University Texas, MD Anderson Houston, USA * These authors have contributed equally to this work Correspondence to: Hou, email: Keywords : multiple myeloma;...
Abstract Liquid–liquid phase separation is considered a generic approach to organize membrane-less compartments, enabling the dynamic regulation of phase-separated assemblies be investigated and pivotal roles protein posttranslational modifications demonstrated. By surveying subcellular localizations human deubiquitylases, USP42 was identified form nuclear punctate structures that are associated with properties. Bioinformatic analysis demonstrated C-terminal sequence intrinsically...
STUDY QUESTIONHow is vascular endothelial growth factor (VEGF) expression regulated by hypoxia inducible 1 alpha (HIF1A) during menstruation?
This study examined the underlying mechanism of miR-215-5p in multiple myeloma (MM) at molecular level. was upregulated bone marrow specimens patients with MM and cell lines through real-time polymerase chain reaction, downregulation related to poor survival MM. The results Western blot assay showed that PI3K/AKT/mTOR signaling pathway activated found negatively correlate runt-related transcription factor 1 (RUNX1) expression clinical samples. Therefore, test probable mechanisms regulation...
Abstract ErbB2 overexpression identifies a subclass of breast cancer as ErbB2-positive that is frequently associated with poor prognosis. Current ErbB2-targeted therapies have profoundly improved patient outcomes, but mutations occurring in been shown to confer drug resistance. Induction degradation was proposed an intriguing strategy battle and reduced mutation-incurred Although multiple HSP90 inhibitors demonstrated effectively trigger degradation, none succeeded the clinical evaluations....
Members from the RAS GTPase superfamily have been closely implicated in tumorigenesis of various human cancers. Recent sequencing analysis lung adenocarcinoma has revealed prevalence alterations RIT1 gene that is a close paralog. However, relative to subfamily members KRAS, NRAS, and HRAS, our characterization oncogenic properties remains incomplete. Therefore, further investigation on will facilitate future development targeted therapies. Our bioinformatic cancer predicted poor survivals...
Although chemotherapy-based immunotherapy has promoted tumor therapeutic effects, it is offseted by the negative immune regulation of microenvironment (TME). Herein, a pH-responsive SN-38/CXB@mPEG-PAE nanocomplexes was fabricated for improving the...
Choriocarcinoma is one of the gestational trophoblastic neoplasias (GTNs) that originate in chorionic villi and extravillous trophoblast. Long noncoding RNAs (lncRNAs) are a type non-protein-coding have recently been implicated human tumorigenesis. The present study investigated role lncRNA LINC00261 cell proliferation, metastasis, apoptosis choriocarcinoma lines. transcription level was significantly lower tissues Overexpression caused decrease proliferation arrested cycle at G0/G1 phase....
Brassica juncea, a worldwide cultivated crop plant, produces seeds of different colors. Seed pigmentation is due to the deposition in endothelial cells proanthocyanidins (PAs), end products from branch flavonoid biosynthetic pathway. To elucidate gene regulatory network seed B. transcriptomes coat yellow-seeded inbred line and its brown-seeded near- isogenic were sequenced using next-generation sequencing platform Illumina/Solexa de novo assembled. Over 116 million high-quality reads...
DSP (desmoplakin), the most abundant component of desmosomes, which maintain mechanical integrity epithelium, is a genome-wide association study-identified genetic risk locus in human idiopathic pulmonary fibrosis (IPF). Subjects with IPF express significantly higher level than control subjects.
Abstract Long noncoding RNA (lncRNA) exerts a potential regulatory role in tumorigenesis. LncRNA TUG1 expression remains high oral squamous cell carcinoma (OSCC) tissues. However, its biological mechanism OSCC unknown. In this study, cells was detected by quantitative real‐time polymerase chain reaction. Proliferative and migratory potentials of were determined Cell Counting Kit 8, 5‐Ethynyl‐2′‐ deoxyuridine (EdU), Transwell assay, respectively. We identified the target through...