A5100326031- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Craniofacial Disorders and Treatments
- Anesthesia and Neurotoxicity Research
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Treatment of Major Depression
- Temporomandibular Joint Disorders
- Receptor Mechanisms and Signaling
- Orthopaedic implants and arthroplasty
- Neuroinflammation and Neurodegeneration Mechanisms
- Orthodontics and Dentofacial Orthopedics
- Neurogenesis and neuroplasticity mechanisms
- Bone health and treatments
- Visual perception and processing mechanisms
- Cleft Lip and Palate Research
- Aortic Disease and Treatment Approaches
- Bone fractures and treatments
- Bone Tissue Engineering Materials
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Facial Trauma and Fracture Management
- Virus-based gene therapy research
Sichuan University
2015-2025
Beijing Institute of Education
2020-2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2020-2025
China Geological Survey
2021-2025
Harbin Engineering University
2025
Ministry of Natural Resources
2025
State Key Laboratory of Metastable Materials Science and Technology
2024
Shanghai University of Traditional Chinese Medicine
2022-2024
Seventh People's Hospital of Shanghai
2022-2024
Shandong University of Science and Technology
2024
The design and engineering of multifunctional nanostructures with multiple components synergistic properties are in urgent demand for variety acceptable biosensing platforms, enabling users to fulfill tasks a single nanosystem. Herein, we report using an asymmetric hematite-silica hybrid Janus γ-Fe2O3/SiO2 nanoparticles (JFSNs) as platform sensitive colorimetric detection H2O2 glucose. It was demonstrated that JFSNs exhibit intrinsic peroxidase-like catalytic activity. Compared natural...
Dietary fibers/probiotics may relieve constipation via optimizing gut microbiome, yet with limited trial-based evidences. We aimed to evaluate the effects of formulas dietary fibers or probiotics on functional symptoms, and identify modulations microbiota relevance. conducted a 4-week double-blinded randomized placebo-controlled trial in 250 adults constipation. Intervention: A: polydextrose; B: psyllium husk; C: wheat bran + D: Bifidobacterium animalis subsp. lactis HN019 Lacticaseibacillus...
High-performance antireflective and antifogging surfaces are fabricated on planar silica substrates planconvex lenses. Such dramatically suppress reflection over a large range of wavelengths field view. Additionally, the ARS exhibit high-quality superhydrophilic properties. For applications, more mechanical stability better durability than multilayered films. Detailed facts importance to specialist readers published as "Supporting Information". documents peer-reviewed, but not copy-edited or...
Phosphodiesterase-4 (PDE4) plays an important role in mediating memory via the control of intracellular cAMP signaling; inhibition PDE4 enhances memory. However, development inhibitors as enhancers has been hampered by their major side effect emesis. four subtypes (PDE4A–D) consisting 25 splice variants. Mice deficient PDE4D displayed enhancement radial arm maze, water and object recognition tests. These effects were mimicked repeated treatment with rolipram wild-type mice. In addition,...
To evaluate alterations of the intestinal bacteria and its associations with inflammation in acute pancreatitis (AP).A multihospital prospective clinical study was conducted, a total 108 participants were enrolled our study, including 44 severe AP (SAP), 32 mild (MAP), healthy volunteers. The structure microbiota, 10 predominant bacteria, plasma endotoxin, serum cytokines investigated by polymerase chain reaction-denaturing gradient gel electrophoresis, real-time quantitative reaction,...
Neuroinflammation often results in enduring cognitive impairment and is a risk factor for postoperative dysfunction. There are currently no effective treatments infection-induced impairment. Previous studies have shown that the iron chelator deferoxamine (DFO) can increase resistance of neurons to injury disease by stimulating adaptive cellular stress responses. However, impact DFO on sequelae neuroinflammation unknown. A mouse model lipopolysaccharide (LPS)-induced was established evaluate...
Comparative effectiveness research (CER) often includes observational studies utilizing administrative data. Multiple conditioning methods can be used for CER to adjust group differences, including difference-in-differences (DiD) estimation. This study presents DiD and demonstrates how apply this method estimate treatment outcomes in the setting by MarketScan® Databases multiple sclerosis (MS) patients receiving different therapies. The sample included 6762 patients, with 363 Test Cohort...
Objective Clinical sepsis-associated biomarkers were utilized in a cecal ligation and puncture (CLP) septic mouse model to provide reference for investigating pathophysiological mechanisms evaluating novel therapeutic interventions sepsis. Methods Sepsis mice was induced by CLP, clinical evaluated (survival rate, blood physiological biochemical indices, cytokines, hepatorenal function parameters, coagulation). Results The mortality rate >70%. body temperature, pressure, heart decreased...
Abstract Background Persistent inflammation dysregulation and cognitive decline have been associated with several trauma- stress-related disorders such as posttraumatic stress disorder (PTSD) anxiety disorder. Despite the abundant discoveries of neuroinflammation in disorders, underlying mechanisms still remain unclear. Method Wild-type Nlrp3 −/− mice were exposed to electric foot shocks contextual fear memory paradigm. Three hours after shocks, activation NLRP3 inflammasome was investigated...
Adv. Mater. 2020, 32, 1906641 In the originally published version of this article, data for histological evaluation CPDs toxicity in brain at CON-7d was duplicated Figure S18, instead correct image CPDs-1d being used. The figure is hereby corrected. authors apologize mistake and any inconvenience caused.
The sensitivity of current surveillance methods for detecting early-stage hepatocellular carcinoma (HCC) is suboptimal. Extracellular vesicles (EVs) are promising circulating biomarkers early cancer detection. In this study, we aim to develop an HCC EV-based surface protein assay detection HCC.Tissue microarray was used evaluate four potential HCC-associated markers. An EV assay, composed covalent chemistry-mediated purification and real-time immuno-polymerase chain reaction readouts,...
Abstract Background: Posttraumatic stress disorder (PTSD) and depression are highly comorbid. Psilocybin exerts substantial therapeutic effects on by promoting neuroplasticity. Fear extinction is a key process in the mechanism of first-line exposure-based therapies for PTSD. We hypothesized that psilocybin would facilitate fear hippocampal Methods: First, we assessed percentage freezing time an auditory cued conditioning (FC) paradigm mice. was administered 30 min before training. testing...
Background: Psilocybin offers new hope for treating mood disorders due to its rapid and sustained antidepressant effects, as standard medications require weeks or months exert their effects. However, the mechanisms underlying this action of psilocybin have not been identified. Aims: To investigate whether has antidepressant-like effects in mice potential are related promoted neuroplasticity. Methods: We first examined normal by forced swimming test chronic corticosterone (CORT)-exposed...
Mouth ulcers, a highly prevalent ailment affecting the oral mucosa, leading to pain and discomfort, significantly impacting patient’s daily life. The development of innovative approaches for ulcer treatment is great importance. Moreover, deeper more comprehensive understanding mouth ulcers will facilitate therapeutic strategies. environment possesses distinct traits as it serves gateway digestive respiratory systems. permeability various epithelial layers can influence drug absorption....
The accurate prediction of the spatial distribution soil organic carbon (SOC) and identification mechanisms underlying its differentiation are paramount significance for conservation utilization land regional sustainable development. A total 512 samples were collected from Wuchang Shuangcheng County in Harbin City, Heilongjiang Province, China, which served as study area. Six machine learning models, including Random Forest (RF), AdaBoost, Support Vector Regression (SVR), weighted average,...