A5091770604- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Musculoskeletal synovial abnormalities and treatments
- Immune cells in cancer
- T-cell and B-cell Immunology
- interferon and immune responses
- Circular RNAs in diseases
- Immunodeficiency and Autoimmune Disorders
- Traditional Chinese Medicine Studies
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Pharmacological Effects of Medicinal Plants
- Chemokine receptors and signaling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Shanghai University of Traditional Chinese Medicine
2018-2025
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2020-2025
Shanghai Innovative Research Center of Traditional Chinese Medicine
2022-2023
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Macrophages are key effector cells that play central role in RA pathogenesis through their ability to polarize into distinct functional phenotypes. An imbalance favoring pro-inflammatory M1 macrophages over anti-inflammatory M2 disrupts immune homeostasis exacerbates inflammation. Multiple signaling pathways, including Notch, JAK/STAT, NF-κb, MAPK,...
Rheumatoid arthritis (RA) is an autoimmune disease. Fibroblast-like synoviocytes (FLS) serve a major role in synovial hyperplasia and inflammation RA. (5R)-5-hydroxytriptolide (LLDT-8), novel triptolide derivative, shows promising therapeutic effects for RA now phase II clinical trials China. However, the underlying mechanism of LLDT-8 still not fully understood. Here, we found that inhibited proliferation invasion FLS, as well production cytokines. Microarray data demonstrated upregulated...
ABSTRACT Objective To assess CXC chemokine receptor 5 (CXCR5) circulating DNA methylation differences in autoimmune rheumatic diseases and their relation with clinical features. Methods Targeted sequencing was performed using peripheral blood from 164 rheumatoid arthritis (RA), 30 systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), psoriatic (PsA), 24 Sjögren's syndrome (SS) patients, healthy controls (HC). Results Significant CXCR5 cg19599951 were found between RA HC, as well...
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease in which autophagy pivotal its pathogenesis. This study aims to identify autophagy-related genes associated with RA and investigate their functional roles. Methods We performed mRNA sequencing differentially expressed (DEGs) between osteoarthritis (OA) intersected these obtain DEGs (ARDEGs) RA. Bioinformatics machine learning approaches were used key biomarkers. Functional experiments, including real-time cellular analysis...
Homeodomain-interacting protein kinase 3 (HIPK3) plays an important role in cell proliferation, apoptosis, and inflammation. Over-expression of HIPK3 immune cells rheumatoid arthritis (RA) has been reported. In this study, we investigated blood methylation levels clinical characteristics RA a Chinese population.
Abstract: Psoriasis is a chronic inflammatory skin disease characterized by the excessive proliferation of keratinocytes and heightened immune activation. Targeting pathogenic genes through small interfering RNA (siRNA) therapy represents promising strategy for treatment psoriasis. This mini-review provides comprehensive summary siRNA research targeting pathogenesis psoriasis, covering aspects such as keratinocyte function, cell roles, preclinical animal studies, delivery mechanisms. It...
The proteolytic autophagy system is involved in a major regulatory pathway dexamethasone (Dex)-induced muscle atrophy. Sirtuin 2 (SIRT2) known to modulate signaling, exerting effects skeletal We examined the of SIRT2 on Dex-induced myoatrophy. Tostudy this, mice were randomly distributed among normal, Dex, and sirtinol groups. C2C12 cells differentiated into myotubes transduced with lentivirus carrying Sirt2-green fluorescent protein (GFP) or Sirt2 short hairpin RNA (Sirt2-shRNA)-GFP. To...
Objectives HTR2A is previously identified as a susceptibility gene for rheumatoid arthritis (RA). In this study, we performed the association analysis between DNA methylation of with RA within peripheral blood samples. Methods We enrolled samples from 235 patients RA, 30 osteoarthritis (OA) patients, and healthy controls. The levels about 218 bp chr13: 46898190 to 46897973 (GRCh38/hg38) around cg15692052 were analyzed by targeted sequencing. Results measured status 7 CpGs in promoter region...
Genome-wide association studies have identified >100 genetic risk factors for rheumatoid arthritis. However, the reported variants could only explain less than 40% heritability of The majority is still missing and needs to be with more different approaches populations. In order identify novel function SNPs reveal mechanism pathogenesis arthritis, 4 HLA (HLA-DRB1, HLA-DRB9, HLA-DQB1, TNFAIP3) 225 common located in miRNA, which might influence miRNA target binding or pre-miRNA stability, were...
To assess the differences in circulating DNA methylation levels of CXCR5 between rheumatoid arthritis (RA) and osteoarthritis (OA) healthy controls (HC), correlation changes with clinical characteristics RA patients.
Abstract Objective To identify novel DNA methylation-regulated differentially expressed genes (MeDEGs) in RA by integrated analysis of methylation and RNA-Seq data. Methods The transcription profiles 9 15 OA synovial tissue were generated Illumina 850K BeadChip. Gene set enrichment (GSEA) Weighted gene co-expression network (WGCNA) used to analyze R software. (DEGs), methylated probes (DMPs), (DMGs) analyzed DESeq ChAMP package. functional correlation MeDEGs was Ontology (GO) Kyoto...
Purpose This study aimed to provide a comprehensive understanding of the genome-wide expression patterns in synovial tissue samples patients with rheumatoid arthritis (RA) investigate potential mechanisms regulating RA occurrence and development. Methods Transcription profiles from nine 15 osteoarthritis (OA) (control) East Asian population were generated using RNA sequencing (RNA-seq). Gene set enrichment analysis (GSEA) was used analyze all detected genes differentially expressed (DEGs)...