A5100702473- Nerve injury and regeneration
- Photosynthetic Processes and Mechanisms
- Fungal and yeast genetics research
- Peptidase Inhibition and Analysis
- Plant Stress Responses and Tolerance
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Spinal Cord Injury Research
- Cancer-related Molecular Pathways
- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- Medical Imaging and Analysis
- Neonatal and fetal brain pathology
- Machine Learning in Bioinformatics
- Inflammasome and immune disorders
- RNA Research and Splicing
- Protease and Inhibitor Mechanisms
- Cervical and Thoracic Myelopathy
- Neuroscience and Neuropharmacology Research
- Ocular Oncology and Treatments
- Pancreatic and Hepatic Oncology Research
- ATP Synthase and ATPases Research
Sichuan University
2025
West China Hospital of Sichuan University
2025
Northwest A&F University
2025
Nanjing Agricultural University
2024
Shanghai University of Traditional Chinese Medicine
2013-2024
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2024
Guangzhou Medical University
2024
Guangzhou First People's Hospital
2024
Beijing University of Chinese Medicine
2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2024
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Macrophages are key effector cells that play central role in RA pathogenesis through their ability to polarize into distinct functional phenotypes. An imbalance favoring pro-inflammatory M1 macrophages over anti-inflammatory M2 disrupts immune homeostasis exacerbates inflammation. Multiple signaling pathways, including Notch, JAK/STAT, NF-κb, MAPK,...
Microbes are widely distributed in soils and play a very important role nutrient cycling ecosystem services. To understand the biogeographic distribution of forest soil bacteria, we collected 115 samples typical ecosystems across eastern China to investigate their bacterial community compositions using Illumina MiSeq high throughput sequencing based on 16S rRNA. We obtained 4,667,656 sequences totally more than 70% these were classified into five dominant groups, i.e. Actinobacteria,...
In many neurodegenerative disorders, such as Alzheimer's disease (AD), glutamate-mediated neuronal excitotoxicity is considered the basis for cognitive impairment. The mRNA and protein expression of SERPINA4(Kallistatin) are higher in patients with AD. However, whether Kallistatin plays a regulatory role glutamate-glutamine cycle homeostasis remains unclear. this study, we identified impaired function transgenic (KAL-TG) mice. Baseline glutamate levels were elevated miniature excitatory...
Inhibition of lycopene cyclization decreased the salt tolerance euhalophyte Salicornia europaea L. We isolated a β-lycopene cyclase gene SeLCY from S. and transformed it into Arabidopsis with stable expression. Transgenic on post-germination exhibited enhanced to oxidative stress. After 8 21 d recovery 200 mM NaCl treatment, transgenic lines had higher survival ratio than wild-type (WT) plants. Three-week-old plants treated showed better growth WT photosystem activity less H(2)O(2)...
Background Soil water and nitrogen (N) are considered to be the main environmental factors limiting plant growth photosynthetic capacity. However, less is known about interactive effects of soil N on tree response in temperate ecosystem. Methods/Principal Findings We applied water, alone combination, investigated combined effect different regimes responses Fraxinus mandshurica seedlings. The seedlings were exposed three including natural precipitation (CK), higher (HW) (CK +30%) lower (LW)...
Halophyte, like Salicornia europaea, could make full use of marginal saline land for carbon fixation. How the photosynthesis S. europaea is regulated under high salinity implicates a significant aspect to exploit this pioneer plant in future. Measurement parameters demonstrated reduction 0 and 800 mM NaCl treated plants are more likely due non-stomatal limitation, which might be caused by changes enzymes associated with photosynthesis. Different induced ultrastructure other than...
Abstract The medicinal value of the Ferula L . has been recognized for more than a thousand years. Wild stocks have declined dramatically because high economic led to overharvesting. objective this study was compare rhizosphere microbial community four species [ F. syreitschikowii K.-Pol., gracilis (Ledeb.) Ledeb., ferulaeoides (Steud.) Korov., and lehmannii Boiss.] in northern part Xinjiang, China. 16S rRNA sequences bacteria were obtained with an Illumina paired-end sequence platform....
Abstract Background Freeze–thaw events are common in boreal and temperate forest ecosystems increasingly influenced by climate warming. Soil microorganisms play an important role maintaining ecosystem stability, but their responses to freeze–thaw cycles (FTCs) poorly understood. We conducted a field experiment natural Korean pine broadleaf mixed the Changbai Mountain Nature Reserve, China, determine dynamic of soil microbial communities FTCs. Results Bacteria were more sensitive than fungi...
3006 Background: FORE8394 is an investigational inhibitor (i) of class 1 (V600) and 2 (activating non-V600) BRAF-altered tumors. did not have paradoxical activation the MAPK pathway in nonclinical studies. Methods: In a phase 1/2a study, patients (pts) aged ≥3 years with BRAF-altered, advanced solid or CNS tumors received (900-3600 mg/day mg/m dosing) without pharmacokinetic booster (cobicistat 150 mg/day). metastases prior treatment other BRAFi were allowed. Besides standard safety...
Abstract The Arabidopsis genome contains seven members of Hsp90 . Mutations in plastid AtHsp90 .5 were reported to cause defects chloroplast development and embryogenesis. However, the exact function has not yet been defined. In this study, albino seedlings found among transformed Arabidopsis, which revealed be co‐suppressed plants. accumulation photosynthetic super‐complexes albinos was decreased, expression genes involved photosynthesis significantly down‐regulated. T‐ DNA insertion...
Abstract Background Mesial temporal lobe epilepsy (mTLE) is the most common form of focal epilepsy, often associated with hippocampal sclerosis. Increasing evidence suggests pivotal role neuroinflammation in mTLE onset and progression. Methods We used morphometric similarity network (MSN) analysis Allen Human Brain Atlas (AHBA) database to investigate structural changes between healthy controls, as well correlation inflammation-related gene expression. Results identified widespread...
Summary Drought is a major environmental constraint to wheat production, yet the genetic and molecular mechanisms underlying drought tolerance remain poorly understood. A gain‐of‐function protein variant TaDTG6‐B Del574 has been identified positively regulates TaPIF1 transcription enhance tolerance. However, precise pathways driving this response are be fully characterized. In study, we demonstrate that plays crucial role in mediating by regulating stomatal aperture control transpiration....
Evidence shows urine specimens from different women have populations of bacteria. The co-occurrence hypertension and hyperlipidemia in those with diabetes may alter the composition microenviroment bladder which bacteria live. aim this study was to characterize urinary microbiota type 2 mellitus only plus and/or hyperlipidemia, explore whether is affected by fasting blood glucose, pressure, lipids. We enrolled 28 individuals only, 24 hypertension, 7 11 both hyperlipidemia. Modified midstream...
Rationale: Understanding the roles of small nucleolar RNAs (snoRNAs) in hepatocarcinogenesis will provide new avenues to identify diagnostic and therapeutic targets for hepatocellular carcinoma (HCC). Our previous research confirmed tumor-suppressive effect Up-frameshift 1 (Upf1) HCC. Herein, we examined expression profiles snoRNAs regulated by Upf1 hepatoma cells. Methods: We cells using RNA-sequencing analysis then investigated significance SNORD52 HCC tissue different cell lines. The...
Fibrin has been widely used in wound healing. However, its benefit for spinal cord injury (SCI) is limited. In this study, we investigated the impact of fibrin scaffolds containing ectomesenchymal stem cells (EMSCs) on histological and behavioral recovery after SCI compared it with alone. To achieve this, EMSCs derived from adult rat nasal respiratory mucosa were cultured, characterized transfected green fluorescent protein adenovirus before transplantation. Then, Sprague-Dawley host rats...
Fibroblast growth factor receptor (FGFR)-4/FGF19 pathway dysregulation is implicated in hepatobiliary and other solid tumors. INCB062079, an oral, selective, FGFR4 inhibitor, inhibits FGF19/FGFR4-driven liver cancer models. This was a two-part, phase I study (NCT03144661) previously treated patients with advanced The primary objective to determine safety, tolerability, maximum tolerated dose (MTD), while secondary objectives included pharmacokinetics, pharmacodynamics (plasma FGF19; bile...
BackgroundXingnaojing (XNJ) injection, an extract derived from traditional Chinese medicine, is commonly used to treat ischemic stroke (IS). Previous studies have shown that XNJ has the ability alleviate apoptosis in cerebral ischemia-reperfusion injury. However, potential mechanisms not been clarified.ObjectiveTo identify neuroprotective effect of and explore whether inhibits cell associated with endoplasmic reticulum stress (ERS) after IS.MethodsIn this study, cultured hippocampal neurons...