A5101871284- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Research and Treatments
- Circular RNAs in diseases
- Nonlinear Partial Differential Equations
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Advanced Mathematical Modeling in Engineering
- RNA Research and Splicing
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Epigenetics and DNA Methylation
- Gastrointestinal motility and disorders
- Diverticular Disease and Complications
- Cancer-related Molecular Pathways
- Hepatitis B Virus Studies
- Advanced Mathematical Physics Problems
- Pelvic floor disorders treatments
- Cancer, Lipids, and Metabolism
- Diagnosis and treatment of tuberculosis
- Gallbladder and Bile Duct Disorders
Zhongnan Hospital of Wuhan University
2014-2024
Wuhan University
2014-2024
China University of Geosciences
2024
First Affiliated Hospital of GuangXi Medical University
2023
Guangxi Medical University
2023
University of South China
2017-2019
Hunan University
2014
Hepatocellular carcinoma (HCC) is the third leading cause of cancer‑related mortality worldwide. Recent studies have demonstrated that long non‑coding RNAs (lncRNAs) are key in carcinogenesis. The aim present study was to investigate role lncRNA GAS5 HCC tissues and define growth arrest‑specific 5 (GAS5) regulation hepatoma cell proliferation, invasion apoptosis. Quantitative polymerase chain reaction situ hybridization were performed expression tumor corresponding adjacent from 50 patients...
Indocyanine green (ICG) fluorescence imaging technology is increasingly widely used in laparoscopic hepatectomy. However, whether it can provide long-term survival benefits to patients with liver malignancies remains unclear. This study investigated the clinical effect of hepatectomy for hepatocellular carcinoma (HCC) using ICG technology. We retrospectively analyzed HCC who underwent at Zhongnan Hospital Wuhan University from January 2016 December 2020. Propensity score matching (PSM) was...
To study the effect of hydroxyapatite (HAP) nanoparticles on human hepatoma cell line BEL-7402 in vitro.The was cultured and treated with HAP at various concentrations. Growth suppression detected MTT colorimetric assay, apoptotic alterations were evaluated by cytochemical staining (Hoechst 33258), transmission electron microscopy (TEM), flow cytometry (FCM).HAP inhibited growth cells a dose-dependent manner, IC(50) values 29.30 mg/L. Treated 50-200 mg/L for 48 h, apoptosis nuclear chromatin...
Long non-coding RNA PTENP1, the pseudogene of PTEN tumor suppressor, was previously reported to be a tumour suppressor in some cancer types. However, precise effects mediated by PTENP1 transcripts within intricate regulatory networks involving molecular interactions with and tumorigenicity hepatocellular carcinoma (HCC) remains elusive. Here, we identify critical biological functions discuss whether could directly interact miR-193a-3p affect progression HCC both vitro vivo. We demonstrated...
Abstract Serum deprivation-response protein (SDPR), a phosphatidylserine-binding protein, which is known to have promising role in caveolar biogenesis and morphology. However, its function hepatocellular carcinoma (HCC) was still largely unknown. In this study, we discussed the characterization identification of SDPR, present it as novel apoptosis candidate incidence HCC. We identified 81 HCC cases with lower SDPR expression tumor tissues help qRT-PCR assay, potentially associated poor...
// Cheng Gong 1 , Jing Fang 2 Guang Li Han-Han Liu 3 and Zhi-Su Department of General Surgery, Research Center Digestive Diseases, Zhongnan Hospital Wuhan University, 430071, P.R. China Oncology, Pu-Ai Hospital, Tongji Medical College, Huazhong University Science Technology, 430034, Pathology, Maternal Child Health Hubei Province, 430070, Correspondence to: Liu, email: hanhanl1010@163.com zsliu53@126.com Keywords: microRNA-126, epidermal growth factor-like domain 7 (EGFL7), hepatocellular...
LncRNA has provided an important new perspective regarding gene regulation. Both the expression and activation of EGFR have been proven to be under tight control GHR pathway. EGFR-AS1 found inhibit EGFR. GHR-siRNA EGFR-AS1-siRNA were transfected into HCC cell lines, a series WB, q-PCR, IF experiments was conducted evaluate whether participated in regulation We that impeded decreased vivo vitro. Then, it verified relatively upregulated tissue, they significantly related some clinical...
Abstract Our previous studies have indicated that long noncoding RNA (lncRNA) SPRY4 intronic transcript 1 (SPRY4‐IT1) was highly expressed in hepatocellular carcinoma (HCC). However, it still remained unclear how SPRY4‐IT1 worked tumorgenesis HCC. In this study, we tested the overexpression of HCC tissues and cells through a quantitative real‐time polymerase chain reaction. Statistical analyses showed upregulation had an association with tumor node metastasis stage, thrombin time, alkaline...
Tumor hypoxia is often associated with resistance to chemotherapy. Multidrug type 1 (MDR1) protein a member of the adenosine triphosphate binding cassette (ABC) proteins, some which are involved in multidrug (MDR) phenotype tumors. Many studies have focused on role these proteins modulating drug resistance, but their effect retention imaging agents less well studied. To study MDR1 expression accumulation <sup>64</sup>Cu-diacetyl-bis(<i>N</i>4-methylthiosemicarbazone) (<sup>64</sup>Cu-ATSM)...
Increasing evidence shows microRNAs (miRNAs) are engaged in hepatocelluar carcinoma (HCC). To identify novel feasible miRNA/mRNA pairs involved hepatocarcinogenesis, an in-depth analysis of miRNomes human non-tumor liver and HCC samples was carried out this study. Firstly, differentially expressed miRNAs were obtained from deep sequencing 15 samples, verified independent data The Cancer Genome Atlas (TCGA) database. Then, mRNA targets selected TCGA, the differential with negative...
Interleukin-6 plays an important role in chronic inflammation as well tumor growth and progression. Here, a case-control study was undertaken to investigate the association of rs1800796 polymorphism IL-6 gene serum levels with disease progression HBV infection. Rs1800796 genotyped 641 Chinese Han patients infection, including 23 IT, 25 IC, 292 CHB, 153 LC, 148 HCC 265 healthy controls. Serum were measured 47 41 49 45 controls, classifications accorded BCLC staging system. We found no...
Adipose-derived stem cells (ADSCs) derived from adipose tissue have the capacity to differentiate into endodermal, mesoderm, and ectodermal cell lineages in vitro, which are an ideal engraft tissue-engineered repair. In this study, human ADSCs were isolated subcutaneous fat. The markers of ADSCs, CD13, CD71, CD73, CD90, CD105, CD166, CYP3A4, ALB detected by immunofluorescence assays. Human cultured a specific hepatogenesis differentiation medium containing HGF, bFGF, nicotinamide, ITS,...
The tumor suppressor gene CD82, also known as KAI1, may act a general of metastasis in numerous types cancer. It is hypothesized that downregulation CD82 expression be an important factor the induction hepatocellular carcinoma (HCC), however mechanism for this requires further study. In present study, relative mRNA and protein levels were determined HCC adjacent non‑tumor tissues. association between hepatitis B virus (HBV) was investigated, by quantitative polymerase chain reaction, western...
Adipose tissue-derived mesenchymal stem cells (AT-MSCs) are an attractive alternative for clinical application due to their minimally invasive accessibility and availability in the body. However, hepatic differentiation efficiency of AT-MSCs is insufficient therapeutic role extrahepatic liver regeneration remains poorly understood. This study was designed investigate effects serum from rats subjected 70% partial hepatectomy (PH) on ability rat vitro, explore potential vivo following PH...
<b><i>Background:</i></b> Surgical treatment of refractory slow transit constipation (STC) is traditionally performed using end-to-side ileorectal anastomosis (SE-IRA) with total abdominal colectomy (TAC). Antiperistaltic side-to-side (SS) IRA suggested to be a superior approach. Employing well-characterized cohort STC patients, we compared the postoperative outcomes 2 surgical approaches. <b><i>Methods:</i></b> A 42 patients underwent TAC for...