A5064363795- Advanced Algorithms and Applications
- Cancer Research and Treatments
- Thermal Radiation and Cooling Technologies
- Advanced Thermoelectric Materials and Devices
- Industrial Technology and Control Systems
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Molecular Biology Techniques and Applications
- Power Systems and Renewable Energy
- Coal Properties and Utilization
- Mesenchymal stem cell research
- Phase Change Materials Research
- Phase Equilibria and Thermodynamics
- Protease and Inhibitor Mechanisms
- Adsorption and Cooling Systems
- Thermal properties of materials
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- TGF-β signaling in diseases
- Pancreatic and Hepatic Oncology Research
- Wind and Air Flow Studies
- Advanced Sensor and Control Systems
- Aerodynamics and Fluid Dynamics Research
- Tissue Engineering and Regenerative Medicine
Chongqing University
2008-2024
Zhongnan Hospital of Wuhan University
2011-2023
Wuhan University
2012-2023
Xi'an University of Science and Technology
2006-2022
China Coal Technology and Engineering Group Corp (China)
2021
Molecular Oncology (United States)
2015-2018
University of Chicago Medical Center
2015-2018
Sichuan Fire Research Institute
2005-2018
University of Chicago
2016
Hubei Zhongshan Hospital
2015
Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities, including cell proliferation, calcium homeostasis, polarity. The role control proliferation stem self-renewal is primarily carried out through the canonical pathway, best characterized among multiple branches. past 10 years has seen rapid expansion our understanding complexity this as many new components have been identified linked to...
The advent of fluorescence-based quantitative real-time PCR (qPCR) has revolutionized the quantification gene expression analysis in many fields, including life sciences, agriculture, forensic science, molecular diagnostics, and medicine. While SYBR Green-based qPCR is most commonly-used platform due to its inexpensive nature robust chemistry, quantifying genes with low abundance or RNA samples extracted from highly restricted limited sources can be challenging because detection sensitivity...
Indocyanine green (ICG) fluorescence imaging technology is increasingly widely used in laparoscopic hepatectomy. However, whether it can provide long-term survival benefits to patients with liver malignancies remains unclear. This study investigated the clinical effect of hepatectomy for hepatocellular carcinoma (HCC) using ICG technology. We retrospectively analyzed HCC who underwent at Zhongnan Hospital Wuhan University from January 2016 December 2020. Propensity score matching (PSM) was...
Although osteosarcoma (OS) is the most common primary malignancy of bone, its molecular pathogenesis remains to be fully understood. We previously found calcium-binding protein S100A6 was expressed in ∼80% analyzed OS and/or metastatic tumor samples. Here, we investigate role growth and progression.S100A6 expression assessed by qPCR Western blotting. Overexpression or knockdown carried out determine S100A6's effect on proliferation, cell cycle, apoptosis, growth, osteogenic...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly malignancies with <5% five-year survival rate due to late diagnosis, limited treatment options and chemoresistance. There thus an urgent unmet clinical need develop effective anticancer drugs treat pancreatic cancer. Here, we study potential repurposing monensin as drug for chemo-resistant Using two commonly-used cancer cell lines PANC-1 MiaPaCa-2, show that suppresses proliferation migration, cycle progression, while solicits...
Ovarian cancer is the most lethal gynecologic malignancy with an overall cure rate of merely 30%. Most patients experience recurrence within 12-24 months and die progressively chemotherapy-resistant disease. Thus, more effective anti-ovarian therapies are needed. Here, we investigate possibility repurposing antibiotic monensin as agent. We demonstrate that effectively inhibits cell proliferation, migration cycle progression, induces apoptosis human ovarian cells. Monensin suppresses multiple...
Successful bone tissue engineering requires at the minimum sufficient osteoblast progenitors, efficient osteoinductive factors, and biocompatible scaffolding materials. We previously demonstrated that morphogenetic protein 9 (BMP9) is one of most potent factors in inducing osteogenic differentiation mesenchymal stem cells (MSCs). Here, we investigated potential use a biodegradable citrate-based thermosensitive macromolecule, poly(polyethyleneglycol citrate-co-N-isopropylacrylamide) (PPCN)...
Nanoscale hydroxyapatite (nano-HAP) has been reported to exhibit anti-cancer effect on several human cancers, but the molecular mechanism of which remains unclear. The aim this study was explore mechanisms by investigating effects nano-HAP gastric cancer SGC-7901 cells. Our results showed that significantly reduced cell viability, and induced apoptosis in cells characterized hypodiploid DNA contents, morphological changes fragmentation. increase accompanied with increased expression Bax, a...
BMP9 induces both osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs). Nell1 is a secretory glycoprotein with osteoinductive anti-adipogenic activities. We investigated the role in BMP9-induced osteogenesis adipogenesis MSCs.Previously characterized MSCs iMEFs were used. Overexpression NELL1 or silencing mouse was mediated by adenoviral vectors. Early late markers assessed staining techniques qPCR analysis. In vivo activity an ectopic bone formation model athymic...
The intervertebral disc (IVD) is a fibrocartilaginous joint between two vertebral bodies. An IVD unit consists of gelatinous central nucleus pulposus, encased by the annulus fibrosus, which sandwiched cartilaginous endplates (EPs). homeostasis can be disrupted injuries, ageing and/or genetic predispositions, leading to degenerative disorders and subsequent lower back pain. complex structure distinct characteristics IVDs warrant establishment robust in vitro organ culture for studying...
Background: BMPs play important roles in regulating stem cell proliferation and differentiation.Using adenovirus-mediated expression of the 14 types we demonstrated that BMP9 is one most potent inducing osteogenic differentiation mesenchymal cells (MSCs), which was undetected early studies using recombinant proteins.Endogenous are expressed as a precursor protein contains an N-terminal signal peptide, prodomain C-terminal mature peptide.Most commercially available proteins purified from...
AIM:To evaluate the effect of hydroxyapatite nanoparticles (Nano HAP) by intravenous injection on inhibition implanted hepatic VX2 tumor growth in rabbits and cell p53/c-Myc protein expression.METHODS: 60 tumor-bearing was randomly divided into five groups.Nano HAP collosol 20 mg/kg, 40 5-FU solutions mg/mL, mixed liquor solution mg/mL Nano mg/kg were infused vein, normal saline conducted as control.The general state, weight, liver function gross volume detected dynamically.The expression...
Interleukin-6 plays an important role in chronic inflammation as well tumor growth and progression. Here, a case-control study was undertaken to investigate the association of rs1800796 polymorphism IL-6 gene serum levels with disease progression HBV infection. Rs1800796 genotyped 641 Chinese Han patients infection, including 23 IT, 25 IC, 292 CHB, 153 LC, 148 HCC 265 healthy controls. Serum were measured 47 41 49 45 controls, classifications accorded BCLC staging system. We found no...