A5001844944- Horticultural and Viticultural Research
- Plant Physiology and Cultivation Studies
- PARP inhibition in cancer therapy
- Fermentation and Sensory Analysis
- Plant Pathogens and Fungal Diseases
- Remote Sensing and Land Use
- Environmental Quality and Pollution
- Molecular Biology Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Plant biochemistry and biosynthesis
- Environmental and Agricultural Sciences
- Food Quality and Safety Studies
- Anesthesia and Sedative Agents
- Plant Reproductive Biology
- Berry genetics and cultivation research
- Regional Economic and Spatial Analysis
- RNA Research and Splicing
- Plant Gene Expression Analysis
- Glycosylation and Glycoproteins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemicals and Antioxidant Activities
- Advanced Computational Techniques and Applications
- Pharmacological Effects of Natural Compounds
Shandong University of Traditional Chinese Medicine
2025
Chinese Academy of Agricultural Sciences
2012-2025
Institute of Pomology
2010-2025
Ministry of Agriculture and Rural Affairs
2011-2025
Fruit Research Institute
2011-2024
Beijing University of Chinese Medicine
2020-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Mudanjiang Medical University
2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2021-2024
Chinese Institute for Brain Research
2024
PARP-1 is an abundant nuclear enzyme that modifies substrates by poly(ADP-ribose)-ylation. has well-described functions in DNA damage repair and also as a context-specific regulator of transcription factors. With multiple models, data show elicits protumorigenic effects androgen receptor (AR)-positive prostate cancer cells, both the presence absence genotoxic insult. Mechanistically, recruited to sites AR function, therein promoting occupancy function. It was further confirmed genetically...
Yersinia pestis, the causative agent of plague, expresses Psa fimbriae (pH 6 antigen) in vitro and vivo. To evaluate potential virulence properties for pneumonic an Escherichia coli strain expressing was engineered shown to adhere three types human respiratory tract epithelial cells. binding specificity confirmed with Psa-coated polystyrene beads by inhibition assays. Individual Y. pestis cells were found be able express capsular antigen fraction 1 (F1) concomitantly on their surface when...
We previously showed that pirfenidone, an anti-fibrotic agent, reduces lung allograft injury or rejection. In this study, we tested the hypothesis pirfenidone has immune modulating activities and evaluated its effects on function of T-cell subsets, which play important roles in rejection.We first whether alters proliferation cytokine release response to receptor (TCR) activation, regulatory T cells (CD4CD25) suppressive using vitro assay. Additionally, alloantigen-induced vivo were assessed...
Durian (Durio zibethinus) is a tropical fruit valued for its nutritional and commercial significance. In this study, we generated two high-quality, haplotype-resolved, chromosome-level genomes of the durian cultivar 'Kan Yao', each with 28 chromosomes. The total genome lengths were 737.2 Mb 763.8 Mb, contig N50 values 22.9 21.5 scaffold 25.9 26.7 respectively. Nineteen chromosomes assembled without gaps, while remaining nine contained 1 to 10 gaps. Genome annotation identified 53,125 53,101...
Light quality significantly affects photosynthetic efficiency in plants. The mechanisms for how light photosynthesis grape is poorly understood. Therefore, to investigate the effects of different qualities on chloroplast ultrastructure and efficiency, two cultivars ‘Italia’ (slower speed leaf senescence) ‘Centennial Seedless’ (faster grown under protected delayed conditions were used. three treatments, replicated times, control (no supplemental lighting), red blue light. Chlorophyll content,...
Researches using resting-state functional magnetic resonance imaging (rs-fMRI) have applied different regional measurements to study the intrinsic brain activity (IBA) of patients with Parkinson’s disease (PD). Most previous studies only examined static characteristics IBA in PD, neglecting dynamic features. We sought explore concordance between dynamics rs-fMRI indices. This included 31 healthy controls (HCs) and 57 PD calculate volume-wise (across voxels) voxel-wise periods) a sliding time...
Brain activity is time varying and dynamic, even in the resting state. However, little attention has been paid to dynamic alterations regional brain Parkinson’s disease (PD). We aimed test for differences homogeneity (dReHo) between PD patients healthy controls (HCs) further investigate pathophysiological meaning of this altered dReHo PD. included 57 31 HCs with rs-fMRI scans neuropsychological examinations. Then, ReHo were calculated all subjects. compared then analyzed associations...
Aroma is an important quality trait of grapes and often the focus consumers, viticulturists grapevine breeders. Kyoho a hybrid between Vitis vinifera labrusca with strawberry-like scent, while 87-1 early-ripening mutant Muscat hamburg, belonging to vinifera, rose scent. In this study, we compared their aroma compositions concentrations during berry development by headspace-SPME combined gas chromatography-mass spectrometry (GC-MS), analyzed expression differences enzyme-encoding genes in...
The incidence of ulcerative colitis (UC) is increasing steadily in developed countries, it plaguing nearly 1 million people the United States and European while developing countries have had a rapidly increased over past decades. Curcuma widely used treating malaria, UC, Crohn's disease, colon cancer, which lead to diarrhea bloody stool. However, systemic mechanism curcuma UC still unclear. Our work was supposed expound how does alleviate comprehensive systematic way by network pharmacology,...
Intranasal dexmedetomidine can provide adequate sedation during short procedures. However, previous literature investigating the single-dose use of intranasal for transthoracic echocardiography in younger children is scarce, and effects age on with remain controversial.This study was to determine 50% effective dose estimate 95% induce pediatric patients noncyanotic congenital heart disease, also effect required sedation.Patients were stratified into three groups 1-6 months, 7-12 13-36...
This study investigated the influence of red, green, blue, and white paper bags on free volatile compound development Kyoho grape berries from green to harvest. Seven functional groups volatiles were identified during including esters, aldehydes, alcohols, terpenes, ketones, acids, hydrocarbons. Esters aldehydes abundant in berries, mainly represented by ethyl acetate, butyrate, (E)-2-hexenal. They accumulated quickly after veraison slightly decreased toward maturation. Red, promoted...
BackgroundXingnaojing (XNJ) injection, an extract derived from traditional Chinese medicine, is commonly used to treat ischemic stroke (IS). Previous studies have shown that XNJ has the ability alleviate apoptosis in cerebral ischemia-reperfusion injury. However, potential mechanisms not been clarified.ObjectiveTo identify neuroprotective effect of and explore whether inhibits cell associated with endoplasmic reticulum stress (ERS) after IS.MethodsIn this study, cultured hippocampal neurons...
The highbush blueberry (Vaccinium corymbosum) Duke, was used to construct a de novo transcriptome sequence library and perform data statistical analysis. Mega 4, CLC Sequence Viewer 6 software, quantitative PCR were employed for bioinformatics expression analyses of the basic helix-loop-helix (BHLH) transcription factors sequencing library. results showed that 28.38 gigabytes valid obtained from assembled into 108 033 unigenes. Functional annotation 32 244 unigenes annotated Clusters...
Colistin has been used as a growth promotant in livestock feed for many years. In China, mcr-1-positive Escherichia coli strains have isolated from humans, chickens, and pigs. To date, there are few reports about the prevalence molecular characteristics of fecal E. bearing mcr-1 meat ducks. this study, gene was investigated among 120 healthy ducks Shandong province China between October 2017 February 2018. A total nine mcr-1-containing were identified two extra-intestinal pathogenic (ExPEC)...
Such phagocytic leukocytes as macrophages and neutrophils are the key cellular components of innate immunity. The actin cytoskeleton is essential for their recruitment activation in infected tissues. We have previously identified p65/L-plastin with Ca2+-, calmodulin-, β-actin-binding domains macrophages. In order to further investigate p65/L-plastin-involved functions, we cloned cDNA murine grancalcin, a possible binding partner p65/L-plastin. According sequence, grancalcin member...