A5075716817- Immune Cell Function and Interaction
- Salivary Gland Disorders and Functions
- T-cell and B-cell Immunology
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Mesenchymal stem cell research
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Connective Tissue Growth Factor Research
- Psoriasis: Treatment and Pathogenesis
- Reproductive System and Pregnancy
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Pharmacological Receptor Mechanisms and Effects
- Long-Term Effects of COVID-19
- Pharmacological Effects of Natural Compounds
- Laser and Thermal Forming Techniques
- Protein Tyrosine Phosphatases
- Medicinal Plants and Bioactive Compounds
- Chemokine receptors and signaling
Dalian Medical University
2020-2024
Sinopec (China)
2024
Xiang Yang No.1 People's Hospital
2021-2024
Zhuhai People's Hospital
2023
Shanghai University
2023
Shengli Oilfield Central Hospital
2023
Nanjing Drum Tower Hospital
2016-2022
Second Affiliated Hospital of Dalian Medical University
2021
Nanjing University
2016-2019
Nanjing Medical University
2016-2019
Although major advancements have made in investigating the aetiology of SLE (systemic lupus erythaematosus), role MDSCs (myeloid-derived suppressor cells) progression remains confused. Recently, some studies revealed that play an important mice. However, proportion and function mice patients are still poorly understood. In present study, we investigated using different stages MRL/lpr specimens from with activity. Results showed splenic granulocytic (G-)MDSCs were significantly expanded by...
Defective clearance of apoptotic cells (ACs) has been suggested to be involved in the pathogenesis systemic lupus erythematosus (SLE). Mesenchymal stem (MSCs) exhibit promising therapeutic effects on SLE, but whether MSCs phagocytose ACs and contributes underlying mechanism treatment SLE remain unknown.Human umbilical cord (UC) were co-cultured with ACs, engulfment by was either detected flow cytometry or observed under confocal laser scanning microscope. Peripheral blood mononuclear (PBMCs)...
Rationale: Although mesenchymal stem cell (MSC) transplantation has been proved to be an effective therapeutic approach treat experimental Sjögren's syndrome (SS), the detailed underlying mechanisms remains unknown. IL-27 diverse influences on regulation of T differentiation and was involved in SS through modulating immune response. Here we aimed explore whether IL-27-mediated cells responsible for beneficial effects MSC SS. Methods: The SS-like symptoms were evaluated deficient recombinant...
Mesenchymal stem cells (MSCs) have been demonstrated to be effective in treating autoimmune diseases including Sjögren's syndrome (SS). We aim compare the effects of MSC transplantation (MSCT) and role serum interleukin-12 (IL-12) SS. IL-12 levels were measured by ELISA. mRNA transcripts dendritic (DCs) determined RT-PCR. After co-culturing with MSCs, mouse human DCs detected. Non-obese diabetic (NOD) mice received MSCT, recombinant IL-12, or anti-IL-12 mAb treatment, respectively. Then,...
Growing evidence suggests that obesity is associated with the susceptibility and disease severity of multiple sclerosis. The chronic inflammation induced by believed to contribute this process. However, immune mechanisms connecting prevalence pathogenesis MS are poorly defined. In study, we show high fat diet (HFD)-induced obese mice developed an exacerbated EAE as indicated higher clinical scores more severe pathological changes in spinal cord than control fed normal (ND), following...
As of September 17, 2021, coronavirus disease 2019 (COVID-19) has infected more than 226 million people in a worldwide pandemic, with conservative estimates suggesting that there are 204 convalescent patients COVID-19. Previous studies have indicated the recovery phase exhibit decreased function multiple organs. In China, traditional Chinese medicine (TCM) treatment is recommended rehabilitation period COVID-19; however, safety and efficacy such remain to be confirmed. The present study...
Abstract Fibroblast-like synoviocytes (FLS) maintain chronic inflammation leading to joint destruction in rheumatoid arthritis (RA). Fatty acid β-oxidation (FAO) regulates cell function. Here, we aimed investigate the effect of FAO enhanced by leptin on characteristics RA-FLS and elucidate potential metabolic mechanism. Key enzymes involved lipid metabolism were detected with qPCR HSF, MH7A line isolated treated RA or healthy control (HC) serum. In some experiments, inhibitor, etomoxir (ETO)...
Mesenchymal stem cells (MSCs) can regulate innate and adaptive immune systems through interacting with directly secreting multiple soluble factors. Due to their immunosuppressive properties, MSC transplantation has been applied treat many clinical experimental autoimmune diseases. However, the therapeutic effects mechanisms by which MSCs myeloid in Sjögren's syndrome (SS) still remain elusive.The number immune-suppressive activity of myeloid-derived suppressor (MDSCs), polymorphonuclear...
Abstract Background Systemic lupus erythematosus (SLE) is characterized by loss of immune tolerance and imbalance cell subsets. Natural killer (NK) cells contribute to regulate both the innate adaptive response. In this study, we aimed detect alterations peripheral NK explore intrinsic mechanisms involving in abnormality SLE. Methods Blood samples from healthy controls (HCs) patients with SLE rheumatoid arthritis (RA) were collected. The count, subsets (CD56 bright , CD56 dim CD57 − + ),...
Abstract Our and other researchers’ previous studies found that myeloid-derived suppressor cells (MDSCs) were increased, these MDSCs, supposed to play immunosuppressive roles, showed significant pro-inflammatory effects in Sjögren’s syndrome (SS). However, the key factors potential mechanisms leading MDSCs be inflammatory remain unclear. In this study, we from SS patients positively correlated with percentages of Th17 cells, disease activity serum autoantibodies, higher levels Fc gamma...
Periodontitis is positively linked to cardiovascular disease (CVD), diabetes, cancer, and increased mortality. Empirically derived clusters of IgG antibodies against 19 selected periodontal microorganisms have been associated with hyperglycemia. We further investigated associations between these serum antibody all-cause CVD mortality in a representative US population. Participants free cancer aged ≥40 y at baseline ( N = 6,491) from the Third National Health Nutrition Examination Survey...
Abstract Objective The mechanism by which mesenchymal stem cell (MSC) transplantation alleviates atherosclerosis in systemic lupus erythematosus (SLE) remains elusive. In this study, we aim to explore the efficacy and of MSC ameliorating SLE. Methods ApoE −/− Fas mice on B6 background were cross-bred generate SLE with atherosclerosis. Myeloid-derived suppressor cells (MDSCs) sorted quantified. apoE either treated anti-Gr antibody or injected MDSCs. lupus-like autoimmunity atherosclerotic...
Reciprocating pumps are widely used in the current oil extraction process, and plunger is a vulnerable part of these that directly determines service life reciprocating pump. To improve plungers, Ni60/WC coatings were applied to surface 45-steel plungers via laser cladding technology wear corrosion resistance. Defect-free dense successfully with strong metallurgical bonding between coating substrate. The consists mainly γ-(Ni, Fe) phase, which contains isotropic isotropic-like crystals,...
Interleukin 27 (IL-27) plays diverse immune regulatory roles in autoimmune disorders and promotes the generation of IL-10 producing CD4+ T cells characterized by immunosuppressive cytokine IL-10. However, whether IL-27 participates pathological progress Sjögren's syndrome (SS) through regulating CD4+IL-10+ remains unknown. Here we aimed to explore potential role pathogenesis SS. The gene knockout non-obese diabetic (Il-27-/-NOD) mice were generated injected with exogenous IL-27. Exogenous...
Interleukin (IL)‑12 modulates the generation and function of various immune cells plays a vital role in pathogenesis Sjögren's syndrome (SS). Myeloid‑derived suppressor (MDSCs) are involved autoimmune diseases by regulating responses. However, it has not been confirmed whether inflammatory IL‑12 participates progression SS via MSDCs. In present study, plasma levels were detected ELISA SS‑like non‑obese diabetic (NOD) mice. The mice treated intraperitoneal injection anti‑IL‑12 antibody,...
Abstract PTFE‐based superhydrophobic coatings have received increasing research and the fabricated exhibited excellent anti‐corrosion, anti‐scaling, anti‐fouling, anti‐icing properties. In order to further enhance hydrophobicity of PTFE coating, a coating consisted nano‐silica polydimethylsiloxane (PDMS) was by deposition annealing treatment. The water contact angle sliding achieved 160.65° 3.02°, respectively, demonstrating it possessed property. Due its surface feature, resistance milk,...
B cell dysfunction and inflammatory cytokine over-production participate in the pathogenesis of rheumatoid arthritis (RA). Here we compared peripheral homeostasis immune functions between RA patients healthy controls (HC) explored vital signaling pathways involved altered cells. We found that showed significantly decreased frequencies CD19+ CD27+ CD24high regulatory (Breg) cells but increased CD38high plasmablasts CD138+ plasma cells, higher levels serum immunoglobulin (Ig)M IgG. Compared to...
Abstract Aim Cardiovascular complications related to atherosclerosis are major causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE). However, the underlying mechanisms not fully understood. Endothelial dysfunction has been identified as having involvement pathogenesis cardiovascular diseases SLE. This study aims evaluate endothelial cell injury mice combination atherosclerosis. Methods The mouse model accelerated ( gld.apoE − / mouse) was generated from...