A5021246987- Advanced Numerical Analysis Techniques
- Topology Optimization in Engineering
- Composite Structure Analysis and Optimization
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Manufacturing Process and Optimization
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Microbial Community Ecology and Physiology
- Advanced Multi-Objective Optimization Algorithms
- Electrospun Nanofibers in Biomedical Applications
- Additive Manufacturing and 3D Printing Technologies
- Ferroptosis and cancer prognosis
- Genomics and Phylogenetic Studies
- Textile materials and evaluations
- Advanced Measurement and Metrology Techniques
- Probabilistic and Robust Engineering Design
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Concrete Corrosion and Durability
- Endoplasmic Reticulum Stress and Disease
- Psoriasis: Treatment and Pathogenesis
- Calcium signaling and nucleotide metabolism
Wuhan Textile University
2018-2024
Affiliated Hospital of Guangdong Medical College Hospital
2024
Tianjin Medical University General Hospital
2024
Renmin Hospital of Wuhan University
2022-2024
Wuhan University
2022-2024
Guangdong Medical College
2016-2023
Tongji University
2022-2023
Zhongkai University of Agriculture and Engineering
2022-2023
General Hospital of Central Theater Command
2023
Arizona State University
2022-2023
Rapid growth of genome data provides opportunities for updating microbial evolutionary relationships, but this is challenged by the discordant evolution individual genes. Here we build a reference phylogeny 10,575 evenly-sampled bacterial and archaeal genomes, based on comprehensive set 381 markers, using multiple strategies. Our trees indicate remarkably closer proximity between Archaea Bacteria than previous estimates that were limited to fewer "core" genes, such as ribosomal proteins. The...
Myocardial fibrosis is a common pathophysiological change in cardiovascular disease, which can cause cardiac dysfunction and even sudden death. Excessively activated fibroblasts proliferate secret excessive extracellular matrix (ECM) components, resulting normal structural damage fibrosis. We previously found that human endothelial progenitor cell (EPC)-derived exosomes, after hypoxia/reoxygenation (H/R) induction, could significantly increase the mesenchymal-endothelial transition (MEndoT)...
Blockade antibodies of the immunoinhibitory receptor PD-1 can stimulate anti-tumor activity T cells, but clinical benefit is limited to a fraction patients. Evidence suggests that BTLA, structurally related PD-1, may contribute resistance targeted therapy, how BTLA and differ in their mechanisms debated. Here, we compared abilities recruit effector molecules regulate cell signaling. While selectively recruited SHP2 over stronger phosphatase SHP1, preferentially SHP1 more efficiently suppress...
An improved optimization method is proposed which combines the particle swarm (PSO) algorithm with dimension reduction kriging surrogate model (DK), namely PSO + DK. In this method, a dynamically constructed and updated between lower dimensional principal components response, instead of high-dimensional design variables response as in traditional methods. The key point DK that analysis (PCA) integrated active learning (AK). Since PCA can reduce effectively, makes construction possible for...
Abstract Glioblastoma (GBM), one of the most common primary intracranial malignant tumours, is very difficult to be completely excised by surgery due its irregular shape. Here, we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles (SPIONs) modified with indocyanine (Cy7) molecules and peptides (ANG or D ANG) locate gliomas guide accurate excision. Both peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties...
Abstract This study aimed to apply pathomics predict Matrix metalloproteinase 9 (MMP9) expression in glioblastoma (GBM) and investigate the underlying molecular mechanisms associated with pathomics. Here, we included 127 GBM patients, 78 of whom were randomly allocated training test cohorts for modeling. The prognostic significance MMP9 was assessed using Kaplan–Meier Cox regression analyses. PyRadiomics used extract features H&E-stained whole slide images. Feature selection performed...
We previously reported that naringin (NRG) protects cardiomyocytes against high glucose (HG)-induced injuries by inhibiting the MAPK pathway. The aim of this study was to test hypothesis NRG prevents from hyperglycemia-induced insult through inhibition nuclear factor kappa B (NF-κB) pathway and upregulation ATP-sensitive K + (K ATP ) channels. Our results showed exposure HG for 24h markedly induced injuries, as evidenced a decrease in cell viability oxidative stress, increases apoptotic...
Large model has emerged as a key enabler for the popularity of future networked intelligent applications. However, surge data traffic brought by applications puts pressure on resource utilization and energy consumption networks. With efficient content understanding capabilities, semantic communication holds significant potential reducing transmission in In this article, allocation driven large models semantic-aware networks is investigated. Specifically, network architecture based scene...
This study aimed to evaluate berberine (BBR) effects on myocardial hypertrophy (MH) and associated mechanisms.BBR MH were evaluated in rats with constriction of abdominal aorta (CAA). qRT-PCR assay was used measure MH-related genes, long non-coding RNAs (lncRNAs) autophagy-related genes expressions. Western blot performed detect autophagy markers expression. Filamentous actin phalloidin expressions detected using immunofluorescence assay.BBR significantly attenuated CAA-induced cardiomyocyte...
Summary This work presents a generalized substructuring‐based topology optimization method for the design hierarchical lattice structures to maximize first eigenvalue. In this method, macrostructure is assumed be composed of substructures with common artificial geometry pattern. And two different yet connected scales are considered through feature parameter. The parameter, which can control material distribution substructure, determines relative density corresponding substructure. Each...
A growing body of evidence has demonstrated that microRNAs (miRs) have pivotal roles in the pathophysiological development mechanisms diabetic cardiomyopathy (DCM). Previous studies miR-186-5p was significantly decreased DCM. In addition, it recently been reported an imbalance miR-186 is associated with a variety physiological and pathological processes. Therefore, present study designed to investigate role high glucose (HG)-induced cytotoxicity apoptosis AC16 cardiomyocytes. Reverse...
The functions of some essential autophagy genes are regulated by microRNAs. However, an ATG3-modulating microRNA has never been reported. Here we show that the transcription miR-495 negatively correlates with translation ATG3 under nutrient-deprived or rapamycin-treated conditions. targets and regulates its protein levels starvation also inhibits starvation-induced decreasing number autophagosomes preventing LC3-I-to-LC3-II transition P62 degradation. These processes reversed overexpression...
Exploring metagenomic contigs and "binning" them into metagenome-assembled genomes (MAGs) are essential for the delineation of functional evolutionary guilds within microbial communities. Despite advances in automated binning algorithms, their capabilities recovering MAGs with accuracy biological relevance so far limited. Researchers often find that human involvement is necessary to achieve representative results. This manual process however expertise demanding labor intensive, it deserves...