A5100690866- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Enzyme Production and Characterization
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Ionic liquids properties and applications
- Advancements in Battery Materials
- Biodiesel Production and Applications
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Sirtuins and Resveratrol in Medicine
- Cholinesterase and Neurodegenerative Diseases
- Angiogenesis and VEGF in Cancer
- Phytochemicals and Antioxidant Activities
- Catalysis for Biomass Conversion
- RNA modifications and cancer
- Edible Oils Quality and Analysis
- Diabetic Foot Ulcer Assessment and Management
- Lipid metabolism and biosynthesis
- Algal biology and biofuel production
- Microbial Metabolism and Applications
- Advanced Cellulose Research Studies
Third Xiangya Hospital
2017-2025
Central South University
2014-2025
Yichun University
2017-2025
Qilu Hospital of Shandong University
2017-2024
Nankai University
2023-2024
Harbin Medical University
2011-2024
Institute of Zoology
2024
Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2024
Nanjing Normal University
2012-2024
Extracellular vesicles (EVs) have been the focus of great interest, as they appear to be involved in numerous important cellular processes. They deliver bioactive macromolecules such proteins, lipids, and nucleic acids, allowing intercellular communication multicellular organisms. EVs are secreted by all cell types, including immune cells natural killer (NK), may play roles system. Currently, a large-scale procedure obtain functional NK is lacking, limiting their use clinically. In this...
ABSTRACT Extracellular vesicles (EVs) are secreted membrane vesicles, which play complex physiological and pathological functions in intercellular communication. Recently, we isolated natural killer (NK) cell‐derived EVs (NK‐EVs) from ex vivo expansion of NK cell cultures. The NK‐EVs contained cytotoxic proteins several activated caspases, they induced apoptosis target cells. In this report, the protein levels NK‐EV isolates were analysed by ELISA. mean values perforin (PFN, 550 ng/mL),...
Abstract Substrate inhibition of enzymes can be a major obstacle to the production valuable chemicals in engineered microorganisms. Here, we show substrate lycopene cyclase as main limitation carotenoid biosynthesis Yarrowia lipolytica . To overcome this bottleneck, exploit two independent approaches. Structure-guided protein engineering yields variant, Y27R, characterized by complete loss without reduction enzymatic activity. Alternatively, establishing geranylgeranyl pyrophosphate...
Selective macroautophagy/autophagy maintains cellular homeostasis through the lysosomal degradation of specific proteins or organelles. The pro-survival effect selective autophagy has been well-characterized, but mechanism by which it drives cell death is still poorly understood. Here, we use a quantitative proteomic approach to identify HPCAL1 (hippocalcin like 1) as novel receptor for CDH2 (cadherin 2) during ferroptosis. HPCAL1-dependent depletion increases susceptibility ferroptotic...
Soluble dietary fiber, notably as an adjunct to early enteral nutrition (EEN), is gaining prominence in clinical therapy. This study evaluates the effect of fructooligosaccharides (FOS), a new soluble on prognosis patients with severe acute pancreatitis (SAP). In retrospective cohort at Third Xiangya Hospital Central South University from July 2017 2023, 110 SAP were analyzed. TPF (enteral nutritional suspension total protein)-normal and TPF-FOS groups both received standard EEN solutions;...
Ferroptosis is a form of inflammatory cell death for which key mediators remain obscure. Here, we report that the proteoglycan decorin (DCN) released by cells are dying from ferroptosis and then acts as an alarm signal to trigger innate adaptive immune responses. The early release DCN during active process involves secretory macroautophagy/autophagy lysosomal exocytosis. Once released, extracellular binds receptor advanced glycosylation end-product-specific (AGER) on macrophages production...
Purpose: We aim to present effective and computer aided diagnostics in the field of ophthalmology improve eye health. This study aims create an automated deep learning based system for categorizing fundus images into three classes: normal, macular degeneration tessellated timely recognition treatment diabetic retinopathy other diseases. Methods: A total 1,032 were collected from 516 patients using camera Health Management Center, Shenzhen University General Hospital University, 518055,...
It has been previously reported that Toll‑like receptor 4 (TLR4)/NF‑κB signaling mediates early inflammation during myocardial ischemia and reperfusion. additionally suggested resveratrol produces cardioprotective anti‑inflammatory effects. The aim of the present study was to investigate whether could modulate TLR4/NF‑κB signaling, reduce neutrophil accumulation TNF‑α induction in an ischemia/reperfusion injured rat heart model. Rats were randomly exposed a sham operation, reperfusion...
Disordered calcium homeostasis can lead to endoplasmic reticulum (ER) stress. Our previous data showed that time course activation of ER stress contributes time-related increase in ischemia-reperfusion (I/R) injury. However, it has not been tested whether PI3K/Akt and JAK2/STAT3 pathways play differential roles reducing protect the heart. In present study, using fasudil which is a specific inhibitor ROCK, we aimed investigate improved SERCA expression activity accounts for reduced by ROCK...
Effects of treating corn and wheat distillers dried grains with solubles (DDGS) a multicarbohydrase alone or in combination protease on porcine vitro fermentation characteristics the matrix structure DGGS before after were studied. Three DDGS samples (wheat sample 1 [wDDGS1], 2 [wDDGS2], [cDDGS]) predigested pepsin pancreatin. Residues then subjected to using buffered mineral solution inoculated fresh pig feces without 3 × factorial arrangement. Accumulated gas production was measured for up...
A two-step strategy was attempted to develop the best amino acid-based basic ionic liquids for catalytic production of biodiesel via transesterification. Cholinium with various acids as paired anions were first synthesized screen anionic moiety. Arginine and histidine selected further structural evolution by varying substituents tetraammonium cation. Tetrabutylammonium arginine ([TBA][Arg]) found be most effective catalyst obtain 98.0%–99.8% yield at 80 °C within 15 min loading 28.84...
The vanadium-dependent chloroperoxidase from<italic>Curvularia inaequalis</italic>is a stable and efficient biocatalyst for the hydroxyhalogenation of broad range alkenes into halohydrins.
Abstract Alka(e)nes are ideal fuel components for aviation, long-distance transport, and shipping. They typically derived from fossil fuels accounting 24% of difficult-to-eliminate greenhouse gas emissions. The synthesis alka(e)nes in Yarrowia lipolytica CO 2 -neutral feedstocks represents an attractive alternative. Here we report that the high-titer harboring a fatty acid photodecarboxylase ( Cv FAP) is enabled by discovered pathway. We find acyl-CoAs, rather than free acids (FFAs),...
Evidence indicates that neutrophil has promoted inflammation in several central nervous system diseases. However, whether the peripheral blood levels of neutrophils are associated with functional outcome after subarachnoid hemorrhage and its potential mechanism remain unclear. In this study, we showed were higher patients (P < 0.001) than healthy subjects. Neutrophil positively Hunt Hess grade modified Rankin Scale scores at 3 months SAH = 0.008). terms mechanism, extracellular traps...