A5031741607- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Kruppel-like factors research
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Power Systems and Renewable Energy
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Ion channel regulation and function
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neural Engineering
Inner Mongolia Electric Power (China)
2024-2025
The University of Texas Southwestern Medical Center
2015-2025
Southwestern Medical Center
2015-2025
Xiangya Hospital Central South University
2018-2024
Central South University
2018-2024
University of South China
2024
Ocean University of China
2004-2021
Xinjiang New Energy Research Institute (China)
2021
Northwestern University
2015-2020
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2019-2020
Biocompatible Fe3O4 magnetic nanocrystals with reactive moieties on the surface can be prepared via a "one-pot" reaction and used straightforwardly in cancer detection by being coupled specific cancer-targeting antibody. It is demonstrated that as-prepared potentially as effective resonance imaging (MRI) contrast agents for diagnosis (see figure). Supporting information this article available WWW under http://www.wiley-vch.de/contents/jc_2089/2006/c0385_s.pdf or from author. Please note: The...
Lipid peroxidation-dependent ferroptosis has become an emerging strategy for tumor therapy. However, current strategies not only selectively induce in malignant cells but also trigger immune simultaneously, which can compromise anti-tumor immunity. Here, we used In-Cell Western assays combined with unbiased drug screening to identify the compound N6F11 as a inducer that triggered degradation of glutathione peroxidase 4 (GPX4), key repressor, specifically cancer cells. did cause GPX4 cells,...
Selective macroautophagy/autophagy maintains cellular homeostasis through the lysosomal degradation of specific proteins or organelles. The pro-survival effect selective autophagy has been well-characterized, but mechanism by which it drives cell death is still poorly understood. Here, we use a quantitative proteomic approach to identify HPCAL1 (hippocalcin like 1) as novel receptor for CDH2 (cadherin 2) during ferroptosis. HPCAL1-dependent depletion increases susceptibility ferroptotic...
Abstract Ferroptosis is a type of lipid peroxidation-dependent cell death that emerging as therapeutic target for cancer. However, the mechanisms ferroptosis during generation and detoxification peroxidation products remain rather poorly defined. Here, we report an unexpected role eukaryotic translation initiation factor EIF4E determinant ferroptotic sensitivity by controlling peroxidation. A drug screening identified 4EGI-1 4E1RCat (previously known EIF4E-EIF4G1 interaction inhibitors)...
The purpose of this study was to investigate invasion- and metastasis-related genes in gastric cancer. To end, we used the transwell system select a highly invasive subcell line from minimally parent cells compared gene expression paired cell lines with high- low-invasive potentials. Lysyl oxidase-like 2 (LOXL2) overexpressed line. Immunohistochemical analysis revealed that LOXL2 markedly increased carcinoma relative normal epithelia, overexpression primary tumor significantly associated...
Abstract KLF4 is an important regulator of cell-fate decision, including DNA damage response and apoptosis. We identify a novel interplay between protein modifications in regulating function. Here we show that arginine methylation by PRMT5 inhibits ubiquitylation VHL thereby reduces turnover, resulting the elevation levels concomitant with increased transcription KLF4-dependent p21 reduced expression KLF4-repressed Bax. Structure-based modelling simulations provide insight into molecular...
Despite widespread utilization of immunotherapy, treating immune-cold tumors has proved to be a challenge. Here, we report that expression the immune checkpoint molecule B7-H4 is prevalent among triple-negative breast cancers (TNBC), where its inversely correlates with PD-L1. Glycosylation interferes interaction/ubiquitination by AMFR, resulting in stabilization. inhibits doxorubicin-induced cell death through suppression eIF2α phosphorylation required for calreticulin exposure vis-à-vis...
Differentiation of the acute myeloid leukemia (AML) cell line HL-60 can be induced by all trans-retinoic acid (ATRA); however, mechanism regulating this process has not been fully characterized. Using bioinformatics and in vitro experiments, we identified microRNA gene expression profile cells during ATRA granulocytic differentiation. Six microRNAs were upregulated treatment, miR-663, miR-494, miR-145, miR-22, miR-363* miR-223; three downregulated, miR-10a, miR-181 miR-612. Additionally,...
The emerging regulatory role of deubiquitinases (DUBs) has been implicated in various fundamental processes and pathogenesis. To determine the pivotal that DUBs play mediating tumorigenesis, we have performed a non-biased screen 67 human based on mammary cell transformation assay. This led to identification USP11 as critical determinant tumor initiation progression. Using an approach protein complex purification coupled with mass spectrometry, further identified XIAP be target for USP11. We...
Abstract Radioresistance has been one of the impediments to effective nasopharyngeal carcinoma (NPC) therapy in clinical settings. Epstein‐Barr virus (EBV) encoded latent membrane protein 1 (LMP1) is expressed NPC and potent effects on radioresistance. It detected extracellular vesicles (EVs) or exosomes shown promote tumor proliferation invasive potential. However, whether LMP1‐positive EVs can confer radioresistance cancer cells mechanism used need be elucidated. In this study, data showed...
Abstract Background Studies have shown that oxidative stress and its resistance plays important roles in the process of tumor metastasis, mitochondrial dysfunction caused by DNA (mtDNA) damage is an molecular event stress. In lung cancer, normal fibroblasts (NFs) are activated as cancer-associated (CAFs), act realms microenvironment (TME) with consequences for growth metastasis. However, activation mechanism whether it participates metastasis through antioxidative remain unclear. Methods The...
Cyclin B1, a key component in the control of cell cycle progression from G2 to M phase, has been implicated tumorigenesis and development malignancy. However, underlying mechanism by which cyclin B1 acts as an important oncogenic molecule remains largely unknown. Here we show that ectopic expression promotes proliferation, enhances motility migration results increased ability cells extravasating through capillary endothelium. Interestingly, isogenic esophageal squamous carcinoma (ESCC)...
This study aimed to identify novel biological markers for the prediction of colorectal cancer liver metastasis.We established two models that mimicked interactions between tumor cells and microenvironment. From these we subcell lines had an enhanced ability metastasize liver. Genes related hepatic metastasis were screened by microarray. The candidate tested immunohistochemistry, their predictive accuracy was assessed cross-validation method independent test set.Highly metastatic colon cell...
Abstract Background Treatment failure for esophageal carcinoma is frequently due to lymph node metastasis and invasion neighboring organs. The aim of the present study was investigate invasion- metastasis-related genes in cells vitro vivo . Methods A model using a Matrigel clonal selection approach employed establish highly invasive subline EC9706-P4 from cell (ESCC) line EC9706. differentially expressed parental determined by gene microarrays were further analyzed RT-PCR Western blotting....
Blockade of mitotic progression is an ideal approach to induce catastrophe that suppresses cancer cell expansion. Cdc20 a critical factor governing anaphase initiation and the exit from mitosis through recruiting substrates APC/C for degradation. Results recent TCGA (The Cancer Genome Atlas) pathological studies have demonstrated pivotal oncogenic role Cdc20-APC/C in tumor as well drug resistance. Thus, deprivation by either inhibition activity or elimination protein via induced degradation...