A5101609339- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Retinal Diseases and Treatments
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Glaucoma and retinal disorders
- Cancer-related Molecular Pathways
- Systemic Lupus Erythematosus Research
- Paleopathology and ancient diseases
- Sepsis Diagnosis and Treatment
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Ureteral procedures and complications
- Epigenetics and DNA Methylation
- Sirtuins and Resveratrol in Medicine
- Computational Drug Discovery Methods
- Ocular Diseases and Behçet’s Syndrome
- Dialysis and Renal Disease Management
- Neurogenesis and neuroplasticity mechanisms
- Telomeres, Telomerase, and Senescence
Hunan Children's Hospital
2016-2025
Central South University
2025
Soochow University
2010-2025
First Affiliated Hospital of Soochow University
2016-2025
Hunan University
2024
Guangzhou Medical University
2015-2024
Guangzhou Center for Disease Control and Prevention
2013-2024
Key Laboratory of Guangdong Province
2014-2024
First Affiliated Hospital of Guangzhou Medical University
2015-2024
Chinese Academy of Sciences
2024
Experimental autoimmune uveitis (EAU) serves as a model for human and cell-mediated autoimmunity in general. EAU induced mice by immunization with the retinal Ag interphotoreceptor retinoid-binding protein CFA is driven Th17 response. Oral calcitriol (1,25-dihydroxyvitamin D(3)) prevented well partly reversed disease suppressed immunological responses. In vitro, directly IL-17 induction purified naive CD4(+) T cells without inhibiting lineage commitment, reflected unaltered RORgammat, STAT3,...
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has emphasized the urgency to develop effective therapeutics. Drug repurposing screening is regarded as one most practical and rapid approaches for discovery such 3C-like protease (3CLpro), or main (Mpro) SARS-CoV-2 a valid drug target it specific viral enzyme plays an essential role in replication. We performed quantitative high-throughput (qHTS) 10 755 compounds consisting...
PFKFB3 (6-phosphofructo-2-kinase) synthesizes fructose 2,6-bisphosphate (F2,6P2), which is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), the rate-limiting enzyme glycolysis. Overexpression leads to high glycolytic metabolism, required for cancer cells survive in harsh tumor microenvironment. The objective this study was investigate antitumor activity PFK15 (1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one), a small molecule inhibitor PFKFB3, against gastric and explore its...
The construction of large structures is one the main development trends space exploration in future, such as stations, solar power and telescopes. It important tendency, which aims to make full use robots assemble autonomously aerospace industry. Considering that on-orbit assembly an effective method solve problem large-scale spatial structures, it necessary motivate facilitate research robotics technologies for assembly. Therefore, this paper, status robot technology relevant recent decades...
Fast applications of GABA (1 mM) to nucleated and outside-out patches excised from granule neurons in cerebellar slices developing rats evoked currents with a double exponential time course reminiscent that IPSCs. A neurosteroid 3alpha, 21dihydroxy-5alpha-pregnan-20-one (THDOC) remarkably increased the slow deactivation constant slowed down recovery desensitization, as estimated by paired-pulse applications. THDOC also reduced amplitude currents, whereas it failed affect fast component its...
Abstract Human autoimmune uveitis is a heterogeneous group of potentially blinding ocular diseases in which most patients who exhibit immunity recognize the same retinal Ag. It represented by model experimental (EAU) induced mice immunization with Ag CFA. Murine EAU characterized Th1/Th17 response pattern, may not represent all types human uveitis. We report this study new injection matured dendritic cells loaded uveitogenic peptide. Dendritic cell-induced demonstrated unique characteristics...
Propolis is a bee-collected natural product and has been proven to have various bioactivities. This study tested the effects of Chinese propolis Brazilian on streptozotocin-induced type 1 diabetes mellitus in Sprague-Dawley rats. The results showed that significantly inhibited body weight loss blood glucose increase diabetic In addition, propolis-treated rats an 8.4% reduction glycated hemoglobin levels compared with untreated Measurement lipid metabolism dyslipidemia helped reduce total...
The tumor suppressor p53 and its signaling pathway play a critical role in prevention. As direct target gene, the of glutaminase 2 (GLS2) tumorigenesis is unclear. In this study, we found that GLS2 expression significantly decreased majority human hepatocellular carcinoma (HCC). Restoration HCC cells inhibits anchorage-independent growth reduces xenograft tumors. Interestingly, negatively regulates PI3K/AKT signaling, which frequently activated HCC. Blocking largely abolishes inhibitory...
To compare the safety and efficacy of fluoroscopic guidance (FG), total ultrasonographic (USG), combined (CG) for percutaneous renal access in mini-percutaneous nephrolithotomy (mini-PCNL).The present study was conducted between July 2014 May 2015 as a prospective randomised trial at First Affiliated Hospital Guangzhou Medical University. In all, 450 consecutive patients with stones >2 cm were to undergo FG, USG, or CG mini-PCNL (150 each group). The primary endpoints stone-free rate (SFR)...
Abstract The SARS-CoV2 coronavirus responsible for the current COVID19 pandemic has been reported to have a relatively low mutation rate. Nevertheless, few prevalent variants arisen that give appearance of undergoing positive selection as they are becoming increasingly widespread over time. Most prominent among these is D614G amino acid substitution in Spike protein, which mediates viral entry. substitution, however, linkage disequilibrium with ORF1b P314L where both mutations almost...
Objectives To compare the safety and effectiveness of super‐mini‐percutaneous nephrolithotomy ( SMP ) retrograde intrarenal surgery RIRS for treatment 1–2 cm lower‐pole renal calculi LPC ). Patients Methods An international multicentre, prospective, randomised, unblinded controlled study was conducted at 10 academic medical centres in China, India, Turkey, between August 2015 June 2017. In all, 160 consecutive patients with were randomised to receive or . The primary endpoint stone‐free rate...