A5039285985- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Electrochemical sensors and biosensors
- Enzyme-mediated dye degradation
- Metal-Catalyzed Oxygenation Mechanisms
- Oxidative Organic Chemistry Reactions
- Gyrotron and Vacuum Electronics Research
- Particle accelerators and beam dynamics
- Biochemical and biochemical processes
- Advanced Photocatalysis Techniques
- Chemistry and Chemical Engineering
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pharmacogenetics and Drug Metabolism
- Asymmetric Hydrogenation and Catalysis
- Advanced Nanomaterials in Catalysis
- Chemical Synthesis and Analysis
- Amino Acid Enzymes and Metabolism
- Magnetic confinement fusion research
- Algal biology and biofuel production
- Synthesis and Catalytic Reactions
- Vanadium and Halogenation Chemistry
- Biofuel production and bioconversion
- Chemical Synthesis and Reactions
- Crystallization and Solubility Studies
- Advanced Chemical Sensor Technologies
Delft University of Technology
2016-2025
Max Planck Institute for Plasma Physics - Greifswald
2003-2024
John Wiley & Sons (United States)
2019-2022
Chemetall (Germany)
2022
Robert Bosch (Germany)
2020-2021
Biocat
2009-2021
Korea Advanced Institute of Science and Technology
2021
University of the Free State
2011-2020
Hudson Institute
2020
Heinrich Heine University Düsseldorf
2018
Over the past decade, metabolomics has developed into a major tool for studying metabolism of organisms and cells, through this approach much been learned about metabolic networks reactions to various external conditions ([Lay et al., 2006][1]). Most work
Biocatalysis is an enabling technology adding to organic oxidation chemistry. Especially the high selectivity of enzymatic coevally operating under mild conditions and not necessitating problematic solvents makes it a very valuable tool for (green) The present state art in use enzymes microorganisms catalytic oxyfunctionalization chemistry reviewed.
When challenged by a difficult reduction reaction, chemist should always also consider biocatalysis in synthesis planning. The inherent selectivity of enzymes has been known for many decades now and the practical applicability undergone dramatic improvements rendering it true alternative to established chemocatalysis. In this contribution recent developments field enzymatic using whole cells isolated are reviewed.
Abstract Redox enzymes have tremendous potential as catalysts for preparative organic chemistry. Their usually high selectivity, paired with their catalytic efficiency under mild reaction conditions, makes them potentially very valuable tools synthesis. The number of interesting monooxygenases, dehydrogenases, reductases, oxidases, and peroxidases is steadily increasing the tailoring a given biocatalyst more becoming standard technology. However, cofactor dependency still represents major...
It's not easy being green: Biocatalysis is generally recognized as an environmentally benign technology. This green claim, however, seldom substantiated. The use of simple mass-based metrics such the E factor may represent appropriate compromise between significance and effort.
Peroxyzymes – biocatalysts utilizing environmentally benign hydrogen peroxide as a co-substrate are promising class of enzymes catalyzing variety important C–H and CC oxidations. This review critically examines recent developments in this field the opportunities for industrial applications.
The search for affordable, green biocatalytic processes is a challenge chemicals manufacture. Redox biotransformations are potentially attractive, but they rely on unstable and expensive nicotinamide coenzymes that have prevented their widespread exploitation. Stoichiometric use of natural not viable economically, the instability these molecules hinders catalytic employ coenzyme recycling. Here, we investigate efficiency man-made synthetic biomimetics NAD(P)H in redox biocatalysis. Extensive...
A recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) bears the promise for efficient and selective synthesis of hydrocarbons carboxylic acids. CvFAP, however, exhibits a clear preference long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that decoy molecule approach enables conversion range by filling up vacant substrate access channel photodecarboxylase. These results not only practical application unique,...
Biocatalysis is propagating into practically every area of organic chemistry, amongst them radical polymerizations. A review the recent developments this dynamic and quickly evolving research presented together with a critical evaluation its potential to yield novel polymers and/or environmentally more benign synthetic procedures.
A series of synthetic nicotinamide cofactors were synthesized to replace natural and promote enoate reductase (ER) catalyzed reactions without compromising the activity or stereoselectivity bioreduction process. Conversions enantioselectivities >99% obtained for C═C bioreductions, process was successfully upscaled. Furthermore, high chemoselectivity observed when employing these cofactor mimics (mNADs) with crude extracts in ER-catalyzed reactions.
The photoenzymatic decarboxylation of fatty acids to alkanes is proposed as an alternative approach for the synthesis biodiesel. By using a recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) we demonstrate irreversible preparation and triglycerides. Several their triglycerides are converted by CvFAP in near-quantitative yield exclusive selectivity upon illumination with blue light. Very promising turnover numbers up 8000 were achieved this proof-of-concept study.
The topic of synthetic nicotinamide cofactor analogues is resurfacing as new approaches are being explored, especially in the areas organic chemistry and biocatalysis. By changing adenine dinucleotide moiety for a simpler alkyl or aryl group taking advantage their ability hydride transfer, these biomimetics used redox reactions catalytic stoichiometric amounts. Alteration amide functional on pyridine ring, thus varying electronic properties, presence divalent metal ions also enable rate...