A5050193476- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Vitamin C and Antioxidants Research
- Inflammasome and immune disorders
- Pneumonia and Respiratory Infections
- Clinical Nutrition and Gastroenterology
- Neonatal Respiratory Health Research
- Anesthesia and Sedative Agents
- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Gut microbiota and health
- Fungal Infections and Studies
- Cancer-related molecular mechanisms research
- Cardiac Arrest and Resuscitation
- Trauma Management and Diagnosis
- Dental Health and Care Utilization
- Immune Response and Inflammation
- Nutrition and Health in Aging
- Anesthesia and Neurotoxicity Research
- Family and Patient Care in Intensive Care Units
- Clostridium difficile and Clostridium perfringens research
- Ferroptosis and cancer prognosis
First Affiliated Hospital of Dalian Medical University
2010-2024
Dalian Medical University
2010-2024
Parkview Health
2024
Creative Commons
2023
To investigate whether XueBiJing injection improves clinical outcomes in critically ill patients with severe community-acquired pneumonia.Prospective, randomized, controlled study.Thirty-three hospitals China.A total of 710 adults 18-75 years old pneumonia.Participants the group received XueBiJing, 100 mL, q12 hours, and control a visually indistinguishable placebo.The primary outcome was 8-day improvement pneumonia severity index risk rating. Secondary were 28-day mortality rate, duration...
Mechanism diagram of astaxanthin alleviating ALI.
Septic shock comprises a heterogeneous population, and individualized resuscitation strategy is of vital importance. The study aimed to identify subclasses septic with non-supervised learning algorithms, so as tailor for each class.Patients in 25 tertiary care teaching hospitals China from January 2016 December 2017 were enrolled the study. Clinical laboratory variables collected on days 0, 1, 2, 3 7 after ICU admission. Subclasses identified by both finite mixture modeling K-means...
The effects of vitamin C supplementation on patients with septic shock remain controversial. We aimed to evaluate the different dosages norepinephrine (NE) synthesis in adult shock.
There is a lack of large-scale epidemiological data on the clinical practice enteral nutrition (EN) feeding in China. This study aimed to provide such Chinese hospitals and investigate factors associated with EN delivery.This cross-sectional was launched 118 intensive care units (ICUs) 116 mainland conducted April 26, 2017. At 00:00 all patients these ICUs were included. Demographic variables 25 obtained. The dates hospitalization, ICU admission initiation reviewed. outcome status 28 days...
Abstract Background Sepsis is one of the most lethal diseases worldwide. Pyroptosis a unique form cell death, and mechanism interaction with sepsis not yet clear. The aim this study was to uncover pyroptosis genes associated provide early therapeutic targets for treatment sepsis. Methods Based on GSE134347 dataset, sepsis-related were mined by differential expression analysis weighted gene coexpression network (WGCNA) . Subsequently, analysed enrichment, protein‒protein (PPI) constructed. We...
Background: Septic patients with persistent lymphopenia may be in an immunosuppressed state. Therefore, we evaluated and compared the clinical characteristics outcomes of septic (≥2d) those nonpersistent lymphopenia. Methods: A retrospective cohort study was designed. total 1306 sepsis who were attended to First Affiliated Hospital Dalian Medical University from March 2016 August 2022 included. The primary outcome 90d mortality. secondary length stay, hospital mortality, 28d incidence...
ABSTRACT Background: Suboptimal ventricular arterial coupling (VAC) is one of the pivotal determinants inefficient heart performance despite appropriate administration fluids or vasopressors in shocks. Here, we investigate VAC patients who are unresponsive to fluid septic shock. Methods: This a retrospective observational study shock (n = 35). was evaluated by effective elastance (EaI), left end-systolic (EesI), and EaI/EesI. Septic successfully resuscitated after pulse indicator continuous...
Abstract Backgroud Thoracic Trauma and Limb Fractures Are the Two most Common Injuries in Multiple Trauma. However, there Is Still a Lack of Mouse Models Combining Tibial Shaft Fracture ( TSF ) In this Study, we Attempted to Develop Novel Model Combined with Blunt Chest BCT ). Methods A total 84 C57BL/6J male mice were used as multiple trauma model. was induced by hitting chests heavy objects, tibia objects after intramedullary fixation. Serum specimens received cardiac puncture at defined...
To compare the characteristics and risk factors of prognosis between elder young patients with acute respiratory distress syndrome (ARDS) in intensive care unit (ICU).The data 150 meeting ARDS Berlin guideline who admitted to ICU Affiliated First Hospital Dalian Medical University from August 2011 November 2013 were retrospectively analyzed. The over 65 years old served as elderly group (n=78), those younger than (n=72), subdivided into survivors non-survivors groups. at admission was...
To the Editor: Norepinephrine (NE), which belongs to catecholamine family, is increasingly produced by sympathetic nervous system and adrenal medulla when host under stress. It has been demonstrated that NE a significant anti-inflammatory effect. In addition, increasing evidence indicated stress hormones are directly involved in interaction between bacteria host. A variety of can exhibit changes growth, virulence, biofilm high concentrations NE. Therefore, this article aimed summarize main...
Guidelines on treating invasive candidiasis recommend initial treatment with a broad-spectrum echinocandin (e.g. micafungin), then switching to fluconazole if isolates prove sensitive (de-escalation strategy). This study aimed evaluate the cost-effectiveness of de-escalation from micafungin vs escalation Chinese public payers perspective.Cost-effectiveness was estimated using decision analytic model, in which patients begin 400 mg/day (escalation) or 100 (de-escalation). From Day 3, when...
Sepsis complicated by ARDS significantly increases morbidity and mortality, underscoring the need for robust predictive models to enhance patient management.
Sepsis is a heterogeneous syndrome. Previous studies have shown controversial results of the effects red blood cell transfusion (RBC) on clinical outcomes septic patients. This study aimed to identify phenotypes sepsis that will benefit from RBC transfusion.Clinical data were extracted Medical Information Mart for Intensive Care III database. The population included adult (age ≥ 18 years) patients with moderate non-bleeding anemia (hemoglobin ≤ 10 g/dL) within 24 hours after admission...