A5055778724- Paraquat toxicity studies and treatments
- Ferroptosis and cancer prognosis
- Plant-based Medicinal Research
- Traditional Chinese Medicine Analysis
- Sepsis Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- COVID-19 and Mental Health
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- RNA modifications and cancer
- Respiratory Support and Mechanisms
- Poisoning and overdose treatments
- COVID-19 and healthcare impacts
- Pesticide Exposure and Toxicity
- Trauma and Emergency Care Studies
- Healthcare professionals’ stress and burnout
- Non-Invasive Vital Sign Monitoring
- Nephrotoxicity and Medicinal Plants
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Biomarkers in Disease Mechanisms
- Bone and Joint Diseases
- Respiratory viral infections research
- Emergency and Acute Care Studies
- Cancer, Lipids, and Metabolism
Second Hospital of Hebei Medical University
2016-2025
Hebei Medical University
2015-2025
Hunan University
2025
Hunan University of Traditional Chinese Medicine
2025
Guizhou University
2024
Affiliated Hospital of Guizhou Medical University
2021
ZheJiang Academy of Agricultural Sciences
2017
Sina (China)
2014
To investigate whether XueBiJing injection improves clinical outcomes in critically ill patients with severe community-acquired pneumonia.Prospective, randomized, controlled study.Thirty-three hospitals China.A total of 710 adults 18-75 years old pneumonia.Participants the group received XueBiJing, 100 mL, q12 hours, and control a visually indistinguishable placebo.The primary outcome was 8-day improvement pneumonia severity index risk rating. Secondary were 28-day mortality rate, duration...
Abstract Ferroptosis is a nonapoptotic form of programmed cell death triggered by the accumulation reactive oxygen species (ROS) depended on iron overload. Although most investigations focus relationship between ferroptosis and cancer, neurodegenerative diseases, ischemia/reperfusion injury, research induced immune-related inflammatory especially sepsis, scarce. Sestrin2 (Sesn2), highly evolutionary stress-responsive protein, critically involved in defense against oxidative stress...
Abstract Mitochondria are the centers of energy and material metabolism, they also serve as storage dispatch hubs metal ions. Damage to mitochondrial structure function can cause abnormal levels distribution ions, leading cell dysfunction even death. For a long time, quality control pathways such dynamics mitophagy have been considered inhibit metal-induced However, with discovery new metal-dependent death including ferroptosis cuproptosis, increasing evidence shows that there is complex...
Background and Objectives: To explore the mechanism of action differential components medicinal edible lilies in treating depression by network pharmacology using UPLC-Q-TOF-MS technology. Methods: The chemical composition was analyzed, screening for unique compounds. Searched depression-related targets. Constructed PPI networks. Performed GO KEGG analyses. Built a components, conducted molecular docking. In addition, contents regaloside before after lily processing were compared Results:...
Abstract Primates, 69% of which are threatened with extinction, the third most specious order mammals. We used primates as model taxa to examine umbrella effects on ecosystem services and protection other vertebrates seed plants in Yunnan Province, China. identified areas conservation priority for 16 primate species determined endemic terrestrial would be protected through a program targeting conservation. Areas high richness were spatially correlated distribution 601 4010 plants. Primate...
Abstract Background To characterize the current state of emergency medicine (EM) and requirements for advancing EM clinical practice, education research in China. Methods An anonymous electronic survey was conducted by Chinese Society Emergency Medicine during September to October 2021. The contained 30 questions divided into 2 sections: development growth. Results 722 hospitals were included, 487 Level III 235 II hospitals. We found that after 40 years development, had established a mature...
To explore the clinical features of acute diquat (DQ) poisoning, and further improve awareness DQ poisoning.A retrospective analysis was performed on data patients with poisoning diagnosed in emergency department Second Hospital Hebei Medical University from January 1, 2019 to December 31, 2021. The included age, gender, exposure routes, presence pesticides (drugs) mixture dosage poison, time taking admitting department, manifestations, laboratory data, treatment, hospital days, prognosis...
Objectives Diquat poisoning is an important public health and social security agency. This study aimed to develop a prognostic model evaluate the value of plasma diquat concentration in patients with acute oral poisoning, focusing on how its impact changes over time after poisoning. Methods was retrospective cohort using electronic healthcare reports from Second Hospital Hebei Medical University. The sample included 80 who were admitted hospital between January 2019 May 2022. Time-to-event...
Septic shock is the development of sepsis to refractory circulatory collapse and metabolic derangements, characterized by persistent hypotension increased lactate levels. Anisodamine hydrobromide (Ani HBr) a Chinese medicine used improve blood flow in disorders. The purpose this study was determine therapeutic efficacy Ani HBr treatment patients with septic shock.This prospective, multicenter, randomized controlled trial focusing on 16 hospitals China. Patients were randomly assigned 1:1...
Atherosclerosis (AS) remains prevalent despite hyperlipidemia-lowering therapies. Although multiple functions of miR-199b-5p have been implicated in cancers, its role endothelial apoptosis and AS unclear. This study aimed to examine the mitochondrial dynamics apoptosis.Human umbilical vein cells (HUVECs) treated with oxidized low-density lipoprotein (ox-LDL) were subjected other treatments, followed by a series analysis. We found that ox-LDL-treated HUVECs associated downregulation,...
Background: Sepsis can cause unpredictable harm, and early identification of risk for mortality may be conducive to clinical diagnosis. The present study proposes assess the efficacy monocyte/high-density lipoprotein cholesterol ratio (MHR) combined with neutrophil/lymphocyte (NLR) on day admission in predictive 28-day critical patients sepsis. Material Methods: We administered observational retrospective cohort research from a single center. correlation variables, together system severity...
Guizhou province in China is rich indigenous chicken breeds, playing an essential role the genetic improvement of modern chickens. Genetic diversity has decreased recent decades due to accelerated breeding processes and changing conservation priorities. To determine population structure we used 55K genotyping arrays conduct analysis on 233 individuals from 8 breeds 263 9 populations. We evaluated parameter (heterozygosity, proportion polymorphic markers, nucleotide diversity), linkage...
The present study aimed to investigate the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and interleukin (IL)‑6 in lung tissue a rat model acute pulmonary edema induced by hypoxia, its pathophysiological significance. A total 48 adult Wistar rats were randomly divided into group A, normal group; B, hypoxia for 24 h; C, D, 72 h. groups B‑D intraperitoneally injected with 6% ammonium chloride establish edema, subsequently sacrificed following successful modeling 24, plasma was...
Abstract Objective To study the efficacy and safety of arbidol hydrochloride tablets as a treatment for influenza-like diseases. Methods In this multicenter, randomized, controlled, open label study, total 412 cases were collected from 14 hospitals in seven regions Hebei Province September 2021 to March 2022. Patients randomly divided into two groups. The control group (n = 207) administered oseltamivir phosphate capsules five days experimental 205) days. primary endpoint was time normal...
Feed represents two-thirds of the total costs poultry production, especially in developing countries. Improvement feed efficiency would reduce amount required for production (growth or laying), cost, and nitrogenous waste. The most commonly used measures are conversion ratio (FCR) residual intake (RFI). As a more suitable indicator assessing efficiency, RFI is defined as difference between observed expected based on maintenance growth laying. However, genetic biological mechanisms regulating...
Objective To investigate the effects of parenteral nutrition (PN) including ω-3 fish-oil emulsion on nutritional state, inflammatory response, and prognosis in patients with acute paraquat poisoning. Methods Patients randomized to receive medium chain triglycerides (MCT)/long (LCT)-based PN (control group) or MCT/LCT-based containing (intervention were compared for 90-day survival short-term treatment efficacy. Results Tumour necrosis factor-α levels significantly lower intervention group (...